INT66240

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.36
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
endothelial cells 1
blood vessels 1
poly 1
cardiomyocytes 1
Ptgis (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 12 99.84 Very High Very High Very High
Enkephalin 12 99.72 Very High Very High Very High
bradykinin 12 93.32 High High
Potency 2 86.28 High High
agonist 5 85.36 High High
adenocard 6 75.60 Quite High
antagonist 21 70.88 Quite High
aspirin 2 66.40 Quite High
Inflammatory response 5 60.64 Quite High
Catecholamine 7 56.80 Quite High
Disease Link Frequency Relevance Heat
Hypertension 90 96.72 Very High Very High Very High
Sprains And Strains 2 93.20 High High
Pulmonary Hypertension 150 92.68 High High
Hypertrophy 36 73.52 Quite High
Increased Venous Pressure Under Development 61 69.52 Quite High
Stroke 6 67.44 Quite High
Dyspnea 1 63.56 Quite High
INFLAMMATION 12 60.24 Quite High
Shock 34 58.04 Quite High
Critical Illness 1 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To overcome this problem, a new drug delivery system was developed by preparing ONO-1301MS, a novel sustained-release prostacyclin analogue polymerized with poly (D,L-lactic-co-glycolic acid) microspheres.
Localization (release) of prostacyclin in poly
1) Confidence 0.58 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.72 Pain Relevance 0.10
Dopamine separately increased prostacyclin release while enkephalin had no significant effect.
Localization (release) of prostacyclin associated with dopamine and enkephalin
2) Confidence 0.38 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.30
Gallopamil decreased prostacyclin release and increased thromboxane release from vessel wall slices in a certain concentration range causing a characteristic dose dependent minimum in the ratio of prostacyclin and thromboxane release.
Localization (release) of prostacyclin
3) Confidence 0.34 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.31
Norepinephrine increased both prostacyclin and thromboxane release.
Localization (release) of prostacyclin
4) Confidence 0.34 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.21
Gallopamil decreased prostacyclin release and increased thromboxane release from vessel wall slices in a certain concentration range causing a characteristic dose dependent minimum in the ratio of prostacyclin and thromboxane release.
Localization (release) of prostacyclin
5) Confidence 0.34 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.30
The ratio of the release of prostacyclin and thromboxane was computed.
Localization (release) of prostacyclin
6) Confidence 0.34 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.21
Isoproterenol increased the ratio of prostacyclin and thromboxane released in cat aortic tissue slices.
Localization (released) of prostacyclin
7) Confidence 0.34 Published 1996 Journal Prostaglandins Section Abstract Doc Link 8908622 Disease Relevance 0 Pain Relevance 0.21
The V1R also mediates prostacyclin and ANP release from cultured rat cardiomyocytes exposed to vasopressin [72].
Localization (release) of prostacyclin in cardiomyocytes
8) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.24 Pain Relevance 0.03
This hyperresponsiveness, the IP receptor insensitivity, and the larger release of endoperoxides and prostacyclin then explain the preponderance of endothelium-dependent contractions and the resulting endothelial dysfunction in the blood vessels (Fig. 2).
Localization (release) of prostacyclin in blood vessels
9) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.27 Pain Relevance 0.16
In the SHR aorta, PGH2 and prostacyclin appear to play the dominant role, mainly because of the abundance in the endothelial cells of prostacyclin synthase, compared with the other specific synthases, resulting in the overwhelming production and release of prostacyclin [43, 47].
Localization (release) of prostacyclin in endothelial cells
10) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.13 Pain Relevance 0.11

General Comments

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