INT66246

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.87
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Mzb1) molecular_function (Mzb1) cytoplasm (Mzb1)
Anatomy Link Frequency
gonadotroph 2
blood 1
smooth muscle 1
muscle 1
pituitary 1
Mzb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 25 100.00 Very High Very High Very High
Trigeminal neuralgia 2 99.66 Very High Very High Very High
Enkephalin 9 97.52 Very High Very High Very High
Cholecystokinin 1 96.28 Very High Very High Very High
substance P 65 95.40 Very High Very High Very High
ischemia 58 95.36 Very High Very High Very High
calcitonin gene related peptide 1 94.60 High High
gABA 60 94.04 High High
antagonist 162 92.44 High High
Neuropeptide 27 91.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 30 100.00 Very High Very High Very High
Headache 2 99.66 Very High Very High Very High
Cv Unclassified Under Development 53 95.36 Very High Very High Very High
Apoptosis 40 95.20 Very High Very High Very High
Reperfusion Injury 2 91.84 High High
Stroke 25 89.52 High High
Nervous System Injury 16 89.36 High High
Stress 242 88.64 High High
Neuropathic Pain 4 88.52 High High
Death 23 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(PACAP) Tyrosine hydroxylase (TH), marker for nonadrenergic nerves, was only found in nerve fibers of the smooth and mixed muscle layers, while enkephalin 8 (ENK-8) was only found in the striated muscle layer.
Gene_expression (found) of PACAP in muscle associated with enkephalin
1) Confidence 0.65 Published 1996 Journal Scand J Urol Nephrol Suppl Section Abstract Doc Link 8908670 Disease Relevance 0.15 Pain Relevance 0.32
Since cross-excitation (a chemically-mediated form of nonsynaptic transmission) within the TG is postulated to play a central role in trigeminal neuralgia, we studied the expression of PACAP and VIP receptors in the TG by RT PCR and immunocytochemistry.
Gene_expression (expression) of PACAP associated with trigeminal neuralgia
2) Confidence 0.54 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225867 Disease Relevance 0.53 Pain Relevance 0.40
The pattern of expression of four genes within the DRG (Lysozyme, PACAP, MET-1 and SNAP25) were further quantified across a time course of 1, 3, 7 and 14 days post axotomy by triplicate northern slot blot (Figure 5).
Gene_expression (expression) of PACAP associated with dorsal root ganglion
3) Confidence 0.36 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139981 Disease Relevance 0.38 Pain Relevance 0.17
The lack of a motor effect of PACAP-(6-38) on its own indicates that VIP acting on PACAP-(6-38)-sensitive receptors (located on neurons and/or the smooth muscle) is unlikely to participate in peristaltic motor regulation.
Gene_expression (acting) of PACAP in smooth muscle
4) Confidence 0.36 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11728434 Disease Relevance 0 Pain Relevance 0.23
In monolayers or in a reverse haemolytic plaque assay system, PACAP inhibits PRL release and has no effect on GH release but PACAP stimulates both GH and PRL release in pituitary tissue blocks and in aggregates as well as in vivo in rats with hypothalamic lesions (in which hypothalamic-releasing hormone influence is abolished) (207).
Neg (inhibits) Gene_expression (inhibits) of PACAP in pituitary
5) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
Well explored paracrine systems are: (i) the gonadotroph–lactotroph axis, of which the mediators remain incompletely defined but could be in part angiotensin II, PACAP, N-POMC and calcitonin; (ii) the gonadotroph–somatotroph axis, which is particularly well developed in fish; (ii) a cholinergic system in corticotrophs targeting somatotrophs, lactotrophs and FS cells; (iii) a GABA-ergic system in somatotrophs; (iv) several inhibitory systems targeting gonadotrophs (e.g. galanin and PRL from lactotrophs and ?
Gene_expression (axis) of PACAP in gonadotroph associated with gaba
6) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.13
PACAP is transiently present in the gonadotrophs during pro-oestrous (187, 188, 547).
Gene_expression (present) of PACAP in gonadotrophs
7) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0
Although PACAP is present in portal blood, it may also have an autocrine action on gonadotrophs, as already above.
Gene_expression (present) of PACAP in blood
8) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0
The protective effect of taurine was accompanied by reduced expression of the UPR-specific proapoptotic protein CHOP and its upstream transcription factors ATF4 and XBP-1 (Figure 4).


Gene_expression (expression) of UPR-specific proapoptotic protein
9) Confidence 0.07 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 1.68 Pain Relevance 0.32
while simultaneously preventing the expression of proapoptotic gene Bax in the
Gene_expression (expression) of proapoptotic gene
10) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 1.00 Pain Relevance 0.20

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