INT66257

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Context Info
Confidence 0.03
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptgs1, Tnf) nuclear envelope (Ptgs1) aging (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) intracellular (Tnf)
Anatomy Link Frequency
macrophages 3
Ptgs1 (Rattus norvegicus)
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 90.56 High High
cytokine 4 90.40 High High
rheumatoid arthritis 1 88.64 High High
metalloproteinase 1 36.56 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Acute-phase Reaction 1 93.60 High High
Rheumatoid Arthritis 1 88.64 High High
Rheumatic Diseases 1 53.36 Quite High
Hypercalcemia 1 49.52 Quite Low
Adhesions 1 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In macrophages, tenidap inhibits the lipopolysaccharide-induced synthesis of interleukins-1 and -6, but it tends to potentiate the lipopolysaccharide-induced synthesis of tumor necrosis factor alpha, due to its cyclooxygenase inhibition.
Negative_regulation (inhibition) of cyclooxygenase in macrophages Positive_regulation (due) of Gene_expression (synthesis) of tumor necrosis factor alpha in macrophages associated with necrosis and cancer
1) Confidence 0.03 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909974 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

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