INT66258

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Context Info
Confidence 0.16
First Reported 1996
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Salpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 100.00 Very High Very High Very High
abdominal pain 1 93.36 High High
Bile 2 77.84 Quite High
Disease Link Frequency Relevance Heat
Death 1 96.00 Very High Very High Very High
Abdominal Pain 1 93.36 High High
Vomiting 1 91.12 High High
Choledocholithiasis 1 83.84 Quite High
Hepatotoxicity 2 75.00 Quite High
Gallbladder Neoplasms 3 62.00 Quite High
Cholecystitis 1 34.64 Quite Low
Metaplasia 2 27.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Negative_regulation (prevented) of Positive_regulation (-induced) of serum enzymes alkaline phosphatase associated with paracetamol
1) Confidence 0.16 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.43
Laboratory studies disclosed increases in the serum alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and serum amylase levels.
Negative_regulation (disclosed) of Positive_regulation (increases) of serum alkaline phosphatase
2) Confidence 0.03 Published 1998 Journal Hepatogastroenterology Section Abstract Doc Link 9840091 Disease Relevance 0.33 Pain Relevance 0.17

General Comments

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