INT66261

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.04
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
platelet 1
Ccl21a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 100.00 Very High Very High Very High
antagonist 3 99.78 Very High Very High Very High
fluoxetine 2 99.44 Very High Very High Very High
5HT 23 99.32 Very High Very High Very High
Analgesic 1 97.52 Very High Very High Very High
Pain 3 90.64 High High
Calcium channel 1 78.40 Quite High
Serotonin 1 75.00 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 96.00 Very High Very High Very High
Splenomegaly 2 93.68 High High
Erythrocytosis 1 92.84 High High
Vomiting 1 91.80 High High
Targeted Disruption 22 91.56 High High
Myalgia 2 91.00 High High
Pain 3 90.64 High High
Thrombophilia 1 83.28 Quite High
Hepatotoxicity 2 75.00 Quite High
Hemorrhage 4 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data revealed that: (i) 5HT injection (at > or = 0.04 micromol/kg) induced a transient P-PLT-A (occurring within 6 seconds), (ii) platelets rapidly took up injected 5HT, (iii) the P-5HT-R was saturated following injection of 5HT at 1 micromol/kg, (iv) ketanserin (5HT(2)-receptor antagonist) strongly inhibited P-PLT-A, (v) under fluoxetine (5HT-uptake inhibitor), 5HT levels at 6 seconds after 5HT injection were markedly higher in blood, but significantly lower in lung (versus fluoxetine-untreated mice), (vi) P-5HT-R was barely detectable in mutant mice with platelets lacking dense bodies, and was much reduced in platelet-depleted mice, (vii) 5HT injected intravenously at 10 micromol/kg had a half-life in the lung of < 20 seconds, and (viii) unlike 5HT, injected histamine was largely excreted by the kidney.
Negative_regulation (inhibited) of PLT in blood associated with antagonist, 5ht and fluoxetine
1) Confidence 0.42 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19967158 Disease Relevance 0 Pain Relevance 1.20
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Negative_regulation (prevented) of ALP associated with paracetamol
2) Confidence 0.41 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.43
Pretreatment of rats with CSE (500 mg/kg orally for 2 days at 12 h intervals) prevented paracetamol (640 mg/kg) and CCl4 (150 ml/kg)-induced rise in serum alkaline phosphatase (ALP) and aminotransferases (AST and ALT).
Negative_regulation (prevented) of ALP associated with paracetamol
3) Confidence 0.41 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15763373 Disease Relevance 0 Pain Relevance 0.18
We also observed a significant decrease in platelet (PLT) counts (Table 1).
Negative_regulation (decrease) of PLT in platelet
4) Confidence 0.09 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1140086 Disease Relevance 0.33 Pain Relevance 0
G-CSF also causes a mild-to-moderate decrease in PLT count from baseline in approximately 25% of healthy allogeneic donors (Tassi et al., 2005).
Negative_regulation (decrease) of PLT
5) Confidence 0.09 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.54 Pain Relevance 0.29

General Comments

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