INT66274

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Context Info
Confidence 0.39
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.16
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Ctbs) carbohydrate metabolic process (Ctbs) lysosome (Ctbs)
Anatomy Link Frequency
lateral 1
neurons 1
nerve 1
brains 1
VLPO 1
Ctbs (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 39 99.68 Very High Very High Very High
spinothalamic tract 12 98.80 Very High Very High Very High
monoamine 5 98.76 Very High Very High Very High
Raphe 7 96.56 Very High Very High Very High
medulla 11 95.28 Very High Very High Very High
gABA 53 95.20 Very High Very High Very High
Raphe magnus 8 91.32 High High
Pain 2 88.52 High High
GABAergic 47 85.36 High High
Spinal cord 1 82.60 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 14 100.00 Very High Very High Very High
Overdose 13 98.86 Very High Very High Very High
Pain 1 88.52 High High
Targeted Disruption 93 81.16 Quite High
Urological Neuroanatomy 12 57.28 Quite High
Generalized Anxiety Disorder 44 56.08 Quite High
Primary Sclerosing Cholangitis 19 29.88 Quite Low
Sleep Disorders 128 5.00 Very Low Very Low Very Low
Sprains And Strains 52 5.00 Very Low Very Low Very Low
Aids-related Complex 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injections of the retrograde tracer cholera toxin B subunit (CTB) into the VLPO produced modest numbers of CTB-labeled monoaminergic neurons in the tuberomammillary nucleus, raphe nuclei, and ventrolateral medulla, as well as a few neurons in the locus coeruleus.
Gene_expression (produced) of CTB in VLPO associated with medulla, locus ceruleus, vibrio infection, raphe and monoamine
1) Confidence 0.39 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11826126 Disease Relevance 0.19 Pain Relevance 0.36
In this study, neurons in the intestinal nerve of Remak (INR) were immunohistochemically labelled by injecting cholera toxin subunit B (CTb) into each one of the jejunal, ileal, cecal and rectal walls.
Gene_expression (injecting) of CTb in nerve associated with vibrio infection
2) Confidence 0.34 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8912257 Disease Relevance 0.10 Pain Relevance 0.08
In WTs, injections of green CTB into the lateral (binocular) zone resulted in a patch of retrogradely labelled cells in the dorsomedial region of the dLGN.
Gene_expression (injections) of CTB in lateral
3) Confidence 0.22 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1964777 Disease Relevance 0.08 Pain Relevance 0
In contrast, when ME was performed at P22, there was only a subtle increase in the CTB-positive area (ME, 15.5±1.2%, n?
Gene_expression (area) of CTB
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
ME at P34 did not have an apparent effect upon the size of the CTB-positive area (ME, 13.6±0.5%, n?
Gene_expression (size) of CTB
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
The size of the CTB-positive area was significantly larger in ME-treated animals than in control animals (ME, 43,673±5,990 µm2, n?
Gene_expression (size) of CTB
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Two of the wells from these injected mice were then also processed for the immunoreaction for the CTb (Goat anti CTb, 1?
Gene_expression (immunoreaction) of CTb
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.17 Pain Relevance 0
Two of the wells from these injected mice were then also processed for the immunoreaction for the CTb (Goat anti CTb, 1?
Gene_expression (immunoreaction) of CTb
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.17 Pain Relevance 0
One week later the mice were sacrificed (after overdose of pentobarbital), brains perfused, and tissue sections processed for immunohistochemistry (Goat anti CTb, 1?
Gene_expression (processed) of CTb in brains associated with overdose
9) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.19 Pain Relevance 0.03
The distribution of retrogradely labeled spinothalamic tract (STT) neurons was analyzed in monkeys following variously sized injections of cholera toxin subunit B (CTb) in order to determine whether different STT termination sites receive input from different sets of STT cells.
Gene_expression (injections) of CTb in neurons associated with spinothalamic tract and vibrio infection
10) Confidence 0.16 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072832 Disease Relevance 0.10 Pain Relevance 0.35
Besides, we previously showed that Fos+ cells localized in the DPGi after PS recovery were retrogradely-labeled after CTb injection in the LC [7].
Gene_expression (injection) of CTb associated with locus ceruleus
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.17 Pain Relevance 0.54

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