INT66280

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 19
Speculated 11
Reported most in Abstract
Documents 534
Total Number 548
Disease Relevance 330.78
Pain Relevance 157.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 53
liver 21
spinal cord 17
RAW 264 13
neuronal 12
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6953 100.00 Very High Very High Very High
cytokine 3623 100.00 Very High Very High Very High
Inflammatory mediators 446 100.00 Very High Very High Very High
chemokine 442 100.00 Very High Very High Very High
COX2 302 100.00 Very High Very High Very High
Glutamate 166 100.00 Very High Very High Very High
substance P 77 100.00 Very High Very High Very High
fluoxetine 16 100.00 Very High Very High Very High
Spinal cord 2268 99.98 Very High Very High Very High
Eae 132 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8200 100.00 Very High Very High Very High
Targeted Disruption 5183 100.00 Very High Very High Very High
Cancer 2065 100.00 Very High Very High Very High
Stress 1598 100.00 Very High Very High Very High
Apoptosis 1331 100.00 Very High Very High Very High
Sepsis 988 100.00 Very High Very High Very High
Adhesions 621 100.00 Very High Very High Very High
Nociception 493 100.00 Very High Very High Very High
Influenza Virus Infection 430 100.00 Very High Very High Very High
Necrosis 413 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that TCCT inhibited LPS-induced NO and PGE2 production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells more effectively than did XCCT or TWCCT.
Gene_expression (expression) of iNOS in RAW 264
1) Confidence 0.78 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16310993 Disease Relevance 0.74 Pain Relevance 0.25
Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed.
Gene_expression (production) of inducible nitric oxide synthase in macrophages
2) Confidence 0.78 Published 2010 Journal Fitoterapia Section Abstract Doc Link 19755140 Disease Relevance 0.59 Pain Relevance 0.58
Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed.
Neg (NO) Gene_expression (expression) of inducible nitric oxide synthase in macrophages
3) Confidence 0.78 Published 2010 Journal Fitoterapia Section Abstract Doc Link 19755140 Disease Relevance 0.59 Pain Relevance 0.57
In addition, cell viability, free radical-scavenging activity and inducible nitric oxide synthase (iNOS) expression were also evaluated.
Gene_expression (expression) of iNOS
4) Confidence 0.78 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.49 Pain Relevance 0.25
In addition, cell viability, free radical-scavenging activity and inducible nitric oxide synthase (iNOS) expression were also evaluated.
Gene_expression (expression) of inducible nitric oxide synthase
5) Confidence 0.78 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.50 Pain Relevance 0.25
The drug at any concentration failed to decrease iNOS mRNA expression in RAW 264.
Gene_expression (expression) of iNOS mRNA in RAW 264
6) Confidence 0.78 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.37 Pain Relevance 0.79
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Gene_expression (expression) of inducible NO synthase in macrophages associated with lidocaine
7) Confidence 0.78 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.47 Pain Relevance 0.30
Expression of iNOS protein in the cells was assessed by Western blot analysis using anti-iNOS antibody.
Gene_expression (Expression) of iNOS protein
8) Confidence 0.78 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.35 Pain Relevance 0.64
Expression of iNOS mRNA in harvested RAW 264 was quantified by Northern blot analysis using mouse iNOS complementary DNA probe.
Gene_expression (Expression) of iNOS mRNA in RAW 264
9) Confidence 0.78 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.38 Pain Relevance 0.55
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Gene_expression (expression) of iNOS in macrophages associated with lidocaine
10) Confidence 0.78 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.47 Pain Relevance 0.30
A possible mechanism of neuroprotection is inhibition of iNOS expression.
Gene_expression (expression) of iNOS
11) Confidence 0.78 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16861428 Disease Relevance 0.41 Pain Relevance 0.21
C. racemosa extracts also reduced iNOS protein expression and iNOS mRNA levels in a dose-dependent manner.
Gene_expression (expression) of iNOS protein
12) Confidence 0.78 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
MATERIALS AND METHODS: Metabolic activity, cell proliferation, reproductive integrity, nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by unstimulated or [LPS/gamma-IFN-stimulated macrophages in vitro was investigated at different times after radiation doses ranging from 0.3 Gy to 10 Gy.
Gene_expression (expression) of iNOS in macrophages
13) Confidence 0.78 Published 1998 Journal Int. J. Radiat. Biol. Section Body Doc Link 9737539 Disease Relevance 0.09 Pain Relevance 0
We investigated dietary arginine-induced intestinal tumorigenesis and NSAID-inhibitory effects in Apc(Min/+) mice differentially expressing nitric oxide synthase-2 (Nos2).
Gene_expression (expressing) of nitric oxide synthase-2 associated with cinod
14) Confidence 0.77 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.68 Pain Relevance 0.28
We investigated dietary arginine-induced intestinal tumorigenesis and NSAID-inhibitory effects in Apc(Min/+) mice differentially expressing nitric oxide synthase-2 (Nos2).
Gene_expression (expressing) of Nos2 associated with cinod
15) Confidence 0.77 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.68 Pain Relevance 0.28
To further understand the mechanism of activity, we investigated whether the extract inhibited the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO) and the expression of TNF-alpha from murine macrophage RAW 264.7 cells.
Gene_expression (expression) of iNOS in RAW 264
16) Confidence 0.77 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17227629 Disease Relevance 0.41 Pain Relevance 0.33
A significant increase in myocardial iNOS expression was observed 24 h after morphine administration (0.3 mg/kg but not 0.1 mg/kg; P < 0.05), whereas endothelial nitric oxide synthase remained unchanged.
Gene_expression (expression) of iNOS
17) Confidence 0.77 Published 2004 Journal Anesthesiology Section Body Doc Link 15220775 Disease Relevance 0.06 Pain Relevance 0
Enhanced iNOS expression and NO production lead to enhanced antioxidant gene expression in oxidative myofibers, providing protection against oxidative stress (Fig. 6).
Gene_expression (expression) of iNOS associated with stress
18) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.61 Pain Relevance 0
-induced iNos expression significantly (Fig. 4C and 4D).
Gene_expression (expression) of iNos
19) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.06 Pain Relevance 0.07
Future investigations should ascertain the functional role of enhanced NO signaling in protection against various types of muscle atrophy and elucidate the molecular mechanism(s) responsible for the fiber type-specific expression of iNos and antioxidant genes.
Gene_expression (expression) of iNos in muscle associated with muscular atrophy
20) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.62 Pain Relevance 0

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