INT66281

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Context Info
Confidence 0.71
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 81
Total Number 85
Disease Relevance 39.49
Pain Relevance 20.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 7
brain 3
lung 2
ventral 2
liver 2
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 758 100.00 Very High Very High Very High
cytokine 576 100.00 Very High Very High Very High
chemokine 24 100.00 Very High Very High Very High
fluoxetine 16 99.56 Very High Very High Very High
lidocaine 28 99.48 Very High Very High Very High
Spinal cord 192 99.32 Very High Very High Very High
Paracetamol 107 99.28 Very High Very High Very High
midbrain 76 97.96 Very High Very High Very High
Sciatic nerve 231 97.64 Very High Very High Very High
Hippocampus 212 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 916 100.00 Very High Very High Very High
Adhesions 95 100.00 Very High Very High Very High
Cancer 74 100.00 Very High Very High Very High
Necrosis 63 100.00 Very High Very High Very High
Infection 943 99.98 Very High Very High Very High
Cold Sores 856 99.84 Very High Very High Very High
Apoptosis 147 99.76 Very High Very High Very High
Obesity 120 99.76 Very High Very High Very High
Parkinson's Disease 658 99.60 Very High Very High Very High
Influenza Virus Infection 240 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggested that DHCD inhibited NO generation by blocking NF-kappaB activation and iNOS gene transcription.
Transcription (transcription) of iNOS
1) Confidence 0.71 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.17
DHCD decreased the levels of protein and mRNA for inducible NO synthase (iNOS).
Transcription (levels) of iNOS
2) Confidence 0.71 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.09 Pain Relevance 0.15
DHCD decreased the levels of protein and mRNA for inducible NO synthase (iNOS).
Transcription (levels) of inducible NO synthase
3) Confidence 0.71 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.09 Pain Relevance 0.15
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (expression) of iNOS in neuronal associated with neuronal nitric oxide synthase
4) Confidence 0.70 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.50 Pain Relevance 0.14
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Transcription (expression) of inducible NO synthase in macrophages associated with lidocaine
5) Confidence 0.69 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.47 Pain Relevance 0.30
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Transcription (expression) of iNOS in macrophages associated with lidocaine
6) Confidence 0.69 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.47 Pain Relevance 0.30
C. racemosa extracts also reduced iNOS protein expression and iNOS mRNA levels in a dose-dependent manner.
Transcription (levels) of iNOS
7) Confidence 0.69 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
METHODS: C. racemosa rhizome and phosphate-buffered saline extracts were analysed for phenolcarboxylic acids and triterpene glycosides using an HPLC photodiode array/evaporative light-scattering detector system. iNOS was characterised by measurement of iNOS protein (immunoblotting), iNOS mRNA (semiquantitative competitive RT-PCR), nitric oxide production (nitrite levels) and nuclear translocation of nuclear factor-kappaB (p65 subunit) protein.
Transcription (characterised) of iNOS
8) Confidence 0.69 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
Our data demonstrated that LPS significantly upregulated transcription of iNOS and CAT-2 but not GTPCH in stimulated macrophages.
Transcription (transcription) of iNOS in macrophages
9) Confidence 0.68 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.11
The mRNA level of nitric oxide synthase (iNos, Nos2) by RT-PCR was also stimulated by fluoxetine.
Transcription (level) of iNos associated with fluoxetine
10) Confidence 0.68 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.09 Pain Relevance 0.66
The mRNA level of nitric oxide synthase (iNos, Nos2) by RT-PCR was also stimulated by fluoxetine.
Transcription (level) of Nos2 associated with fluoxetine
11) Confidence 0.68 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.09 Pain Relevance 0.66
Recent in vitro studies by Imanishi et al. showed that a mouse lung-adapted strain of influenza virus could induce inducible NO synthase (NOS-2) mRNA expression and NOS-2-mediated NO production in murine macrophage cell [5].
Transcription (expression) of NOS-2 in lung associated with influenza virus infection and sprains and strains
12) Confidence 0.68 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 1.15 Pain Relevance 0.18
Next, we tested the effects of compound on cellular iNOS mRNA transcript levels.
Transcription (transcript) of iNOS
13) Confidence 0.68 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0 Pain Relevance 0
The structurally unrelated ER stressor, thapsigargin, also reduced iNOS activity, protein levels, and mRNA transcripts (data not shown).
Transcription (transcripts) of iNOS
14) Confidence 0.68 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.15 Pain Relevance 0
The concentrations of erstressin required to activate UPR signaling and UPR gene expression are the same as those that reduce iNOS mRNA and protein expression and enzyme activity.
Transcription (expression) of iNOS
15) Confidence 0.65 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.13 Pain Relevance 0
Non significant differences were found between genotypes as compared the expression of NOS2 mRNA among theme in sham-operated mice.
Transcription (expression) of NOS2
16) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.60 Pain Relevance 0.57
Therefore, our subsequent aim is to evaluate the mRNA and protein expression of NOS1 and NOS2 isoenzymes in the spinal cord of WT mice at 21 days after sciatic nerve ligation and correlate it with their corresponding behavior responses.
Transcription (expression) of NOS2 in spinal cord associated with sciatic nerve and spinal cord
17) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.14 Pain Relevance 0.93
The mRNA and protein levels of NOS1, NOS2 and NOS3 in the spinal cord of WT and KO mice, at 21 days after surgery, were also assessed.
Transcription (levels) of NOS2 in spinal cord associated with targeted disruption and spinal cord
18) Confidence 0.64 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.79 Pain Relevance 1.00
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (xpressions ) of iNOS
19) Confidence 0.64 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.98 Pain Relevance 0.23
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (xpressions ) of inducible nitric oxide synthase
20) Confidence 0.64 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.98 Pain Relevance 0.23

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