INT66287

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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2000
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.87
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DGCR14) molecular_function (DGCR14)
Anatomy Link Frequency
muscle 2
neuronal 1
leg muscle 1
DGCR14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 48 100.00 Very High Very High Very High
Endep 7 99.38 Very High Very High Very High
qutenza 10 99.28 Very High Very High Very High
Serotonin 3 81.80 Quite High
headache 4 75.00 Quite High
noradrenaline 2 75.00 Quite High
Neurotransmitter 1 55.72 Quite High
visual analogue scale 3 50.08 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Myalgia 24 100.00 Very High Very High Very High
Nociception 12 99.40 Very High Very High Very High
Headache 3 75.00 Quite High
Pain 4 46.76 Quite Low
Cognitive Disorder 3 30.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that amitriptyline reduces ES2 and indicate that ES2 is modulated by serotonergic as well as noradrenergic neuronal pathways.
Regulation (modulated) of ES2 in neuronal associated with endep
1) Confidence 0.24 Published 1996 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 8913195 Disease Relevance 0.22 Pain Relevance 0.77
Isotonic saline did not influence the ES1 or ES2.
Neg (not) Regulation (influence) of ES2
2) Confidence 0.23 Published 1999 Journal Pain Section Abstract Doc Link 10488676 Disease Relevance 0.30 Pain Relevance 0.79
In experiment 3, no significant effects on ES1 and ES2 were observed during painful infusion of hypertonic saline into the leg muscle.
Neg (no) Regulation (effects) of ES2 in leg muscle associated with pain
3) Confidence 0.23 Published 1999 Journal Pain Section Abstract Doc Link 10488676 Disease Relevance 0.32 Pain Relevance 0.79
These results indicate that the effects of tonic jaw-muscle pain on ES2 can be distinguished from a generalized effect of muscle pain.
Regulation (effects) of ES2 in muscle associated with pain and myalgia
4) Confidence 0.23 Published 1999 Journal Pain Section Abstract Doc Link 10488676 Disease Relevance 0.34 Pain Relevance 0.80
The present study examined the efficacy of nociceptive and non-nociceptive perioral stimulation for the modulation of the two exteroceptive suppression periods (ES1 and ES2) in human jaw-closing muscles.
Regulation (modulation) of ES2 in muscles associated with nociception
5) Confidence 0.23 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10883379 Disease Relevance 0.35 Pain Relevance 0.20
Capsaicin alone failed to induce significant changes of ES1 and ES2; tactile stimulation alone induced a significant delay in the onset of ES2 (P < 0.001).
Regulation (changes) of ES2 associated with qutenza
6) Confidence 0.23 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10883379 Disease Relevance 0.35 Pain Relevance 0.45

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