INT663

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 15.95
Pain Relevance 14.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb3) plasma membrane (Adrb3) nucleus (Adrb3)
signal transducer activity (Adrb3)
Anatomy Link Frequency
ventricular myocardium 2
colon 1
atrium 1
skeletal muscle 1
chest 1
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 62 100.00 Very High Very High Very High
agonist 34 99.96 Very High Very High Very High
Angina 18 99.84 Very High Very High Very High
qutenza 12 99.56 Very High Very High Very High
adenocard 2 99.56 Very High Very High Very High
Desipramine 14 99.54 Very High Very High Very High
Restless leg syndrome 7 99.48 Very High Very High Very High
Migraine 6 99.44 Very High Very High Very High
Serotonin 1 99.26 Very High Very High Very High
Action potential 4 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 1 99.88 Very High Very High Very High
Cv General 3 Under Development 16 99.84 Very High Very High Very High
Hypoglycemia 14 99.60 Very High Very High Very High
Diabetes Mellitus 13 99.60 Very High Very High Very High
Aggression 11 99.56 Very High Very High Very High
Hypertension 22 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.48 Very High Very High Very High
Myocardial Infarction 16 99.44 Very High Very High Very High
Headache 5 99.44 Very High Very High Very High
Coronary Artery Disease 22 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beta-adrenoceptor blocking effect of propranolol observed at 10 and 20 min time intervals was abolished in rats exposed to cigarette smoke 24 h after the exposure.
Negative_regulation (abolished) of beta-adrenoceptor
1) Confidence 0.59 Published 1989 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 2612519 Disease Relevance 0.10 Pain Relevance 0
Neurochemical studies show that both lofepramine and its metabolite are potent noradrenaline uptake inhibitors in vitro and evidence is presented to suggest that lofepramine may release this amine following chronic administration in vivo; both drugs slightly increase serotonin turnover under these conditions and down-regulate cortical beta-adrenoceptor function.
Negative_regulation (down-regulate) of beta-adrenoceptor associated with noradrenaline and serotonin
2) Confidence 0.59 Published 1987 Journal Int Clin Psychopharmacol Section Abstract Doc Link 2891742 Disease Relevance 0.33 Pain Relevance 0.68
A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity.
Negative_regulation (decrease) of beta-adrenoreceptor
3) Confidence 0.54 Published 1991 Journal Cor Vasa Section Abstract Doc Link 1655353 Disease Relevance 0.52 Pain Relevance 0.14
Morphometric changes in rabbit ventricular myocardium produced by long-term beta-adrenoceptor blockade.
Negative_regulation (blockade) of beta-adrenoceptor in ventricular myocardium
4) Confidence 0.47 Published 1977 Journal Lancet Section Title Doc Link 72197 Disease Relevance 0.07 Pain Relevance 0.14
In rabbits long-term beta-adrenoceptor blockade did not cause any change in the morphology of individual organelles in the ventricular myocardium.
Negative_regulation (blockade) of beta-adrenoceptor in ventricular myocardium
5) Confidence 0.47 Published 1977 Journal Lancet Section Abstract Doc Link 72197 Disease Relevance 0 Pain Relevance 0
However, even a single dose (in mg/kg) of DMI (15) or the beta-adrenoceptor agonist, clenbuterol (20), induced a rapid (24 hour) and significant reduction of beta-adrenoceptor Bmax (-15%; p < 0.01).
Negative_regulation (reduction) of beta-adrenoceptor associated with agonist
6) Confidence 0.46 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8879672 Disease Relevance 0 Pain Relevance 0.30
It is concluded that the toxicological profile of various beta-blocking drugs might be determined by an yet unknown pharmacological property apart from beta-adrenoceptor blockade or membrane stabilising activity.
Negative_regulation (blockade) of beta-adrenoceptor
7) Confidence 0.43 Published 1984 Journal J. Toxicol. Clin. Toxicol. Section Abstract Doc Link 6502785 Disease Relevance 0.08 Pain Relevance 0.10
The antidepressive activity of propranolol was associated with cerebral beta-adrenoceptor block.
Negative_regulation (block) of beta-adrenoceptor
8) Confidence 0.43 Published 1993 Journal Eksp Klin Farmakol Section Abstract Doc Link 8324486 Disease Relevance 0.09 Pain Relevance 0.14
Intraabdominally applied HCl inhibited colonic motility, which was unaffected by nonselective beta-adrenoceptor blockade (propranolol).
Negative_regulation (blockade) of beta-adrenoceptor
9) Confidence 0.43 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 2990837 Disease Relevance 0.25 Pain Relevance 0.34
The effect of L-norepinephrine was inhibited strongly by preinjection of alpha- and beta-adrenoceptor antagonists.
Negative_regulation (preinjection) of beta-adrenoceptor associated with antagonist
10) Confidence 0.43 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2869167 Disease Relevance 0 Pain Relevance 0.29
The effect of L-norepinephrine was inhibited strongly by premicroinjection of alpha- and beta-adrenoceptor antagonists.
Negative_regulation (premicroinjection) of beta-adrenoceptor associated with antagonist
11) Confidence 0.42 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2871211 Disease Relevance 0 Pain Relevance 0.26
Studies on mechanisms for beta-adrenoceptor mediated inhibition of colon motility.
Negative_regulation (inhibition) of beta-adrenoceptor in colon
12) Confidence 0.42 Published 1985 Journal Acta Physiol Scand Suppl Section Title Doc Link 2869641 Disease Relevance 0 Pain Relevance 0.33
The use of selective beta-adrenoceptor blocking agents revealed both beta 1- and beta 2-adrenoceptor inhibitory interaction by the beta-agonists employed.
Negative_regulation (blocking) of beta-adrenoceptor associated with agonist
13) Confidence 0.41 Published 1985 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2869641 Disease Relevance 0 Pain Relevance 0.32
The selection of a drug may be influenced by concomitant pathology, with positive indications for particular drugs, e.g. coexistent angina, indicating use of a beta-receptor blocking drug or calcium antagonist; fluid retention indicating a diuretic; or contraindication e.g. asthma, and beta-adrenoceptor blocking drugs. beta-Adrenoceptor blocking drugs have the advantage of a long history and of possibly being cardioprotective following myocardial infarction, but they have not yet been established as primary preventive agents in hypertensive patients.
Negative_regulation (blocking) of beta-adrenoceptor associated with asthma, pressure and volume under development, angina, antagonist, hypertension and myocardial infarction
14) Confidence 0.41 Published 1988 Journal Drugs Section Abstract Doc Link 3042360 Disease Relevance 0.70 Pain Relevance 0.15
The effects of beta-adrenoreceptor blockade on oxygen consumption during cardiopulmonary bypass.
Negative_regulation (blockade) of beta-adrenoreceptor
15) Confidence 0.40 Published 1994 Journal Anesth. Analg. Section Title Doc Link 7912042 Disease Relevance 0.09 Pain Relevance 0.08
Effect of beta-adrenoreceptor blockade with nadolol on the duration of local anesthesia.
Negative_regulation (blockade) of beta-adrenoreceptor associated with anesthesia
16) Confidence 0.40 Published 1999 Journal J Am Dent Assoc Section Title Doc Link 10599182 Disease Relevance 0.28 Pain Relevance 0.56
To evaluate the role of beta-adrenoceptor blockade on lower limb circulation in patients with peripheral arterial disease, heart rate, blood pressure, calf blood flow and vascular resistance were measured at rest and during reactive hyperemia in seven patients with hypertension and intermittent claudication.
Negative_regulation (blockade) of beta-adrenoceptor in blood associated with hyperemia, restless leg syndrome, hypertension and peripheral arterial disease
17) Confidence 0.40 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3880687 Disease Relevance 0.45 Pain Relevance 0.17
The value of combined alpha- and beta-adrenoceptor blockade in angina pectoris.
Negative_regulation (blockade) of beta-adrenoceptor associated with angina
18) Confidence 0.40 Published 1983 Journal Postgrad Med J Section Title Doc Link 6647207 Disease Relevance 0.10 Pain Relevance 0.10
Clinical use of beta-adrenoceptor blockade in systemic hypertension.
Negative_regulation (blockade) of beta-adrenoceptor associated with hypertension
19) Confidence 0.40 Published 1990 Journal Drugs Section Title Doc Link 1973382 Disease Relevance 0.48 Pain Relevance 0.23
It is clear that acute beta-adrenoceptor blockade in suspected acute myocardial infarction reduces mortality and morbidity as well as complications such as chest pain and ventricular arrhythmias during the acute phase.
Negative_regulation (blockade) of beta-adrenoceptor in chest associated with angina and myocardial infarction
20) Confidence 0.40 Published 1991 Journal Circulation Section Abstract Doc Link 1683604 Disease Relevance 0.55 Pain Relevance 0.35

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