INT6630

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Context Info
Confidence 0.17
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.07
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1RAP) extracellular region (IL1RAP) plasma membrane (IL1RAP)
intracellular (IL1RAP) protein complex assembly (IL1RAP) signal transducer activity (IL1RAP)
Anatomy Link Frequency
thymocytes 1
IL1RAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 3 99.98 Very High Very High Very High
cytokine 19 99.06 Very High Very High Very High
Inflammation 23 97.00 Very High Very High Very High
Chronic pancreatitis 1 91.28 High High
Arthritis 3 90.00 High High
opioid receptor 1 89.32 High High
antagonist 3 86.56 High High
Osteoarthritis 302 85.96 High High
Opioid 1 70.52 Quite High
rheumatoid arthritis 14 34.04 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 1 98.24 Very High Very High Very High
INFLAMMATION 25 97.00 Very High Very High Very High
Necrosis 4 90.68 High High
Cancer 4 90.32 High High
Arthritis 6 90.00 High High
Osteoarthritis 304 85.96 High High
Osteophyte 5 39.32 Quite Low
Disease 46 36.60 Quite Low
Rheumatoid Arthritis 14 34.04 Quite Low
Pain 18 32.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using gene names also for their protein products, a complex of IL-1 (IL1A or IL1B), IL1RI and IL1RAP are needed for signal transduction.
IL1RAP Binding (complex) of
1) Confidence 0.17 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.70 Pain Relevance 0.44
OBJECTIVE: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP).
IL1RAcP Binding (binds) of associated with cytokine
2) Confidence 0.08 Published 2010 Journal Gut Section Abstract Doc Link 19996325 Disease Relevance 0.10 Pain Relevance 0.18
Data on IL-1 signalling show that after IL-1 binding to the cell membrane IL-1 receptor I, the IL-1 receptor accessory protein (IL-1RAcP) is recruited to form a high-affinity receptor complex, which initiates the intracellular signalling cascade [49,50].
IL-1RAcP Binding (recruited) of
3) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.27 Pain Relevance 0.09
Characterization of [3H]morphine binding to interleukin-1-activated thymocytes.
interleukin-1-activated Binding (binding) of in thymocytes associated with morphine
4) Confidence 0.00 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1331399 Disease Relevance 0 Pain Relevance 0.38

General Comments

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