INT66303

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2009
Negated 1
Speculated 6
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 4.82
Pain Relevance 10.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
neuronal 2
dorsal 1
ileum 1
colon 1
amygdala 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 364 100.00 Very High Very High Very High
fluoxetine 133 100.00 Very High Very High Very High
Serotonin 84 100.00 Very High Very High Very High
withdrawal 18 99.92 Very High Very High Very High
cytokine 63 99.74 Very High Very High Very High
Enkephalin 4 99.74 Very High Very High Very High
Inflammation 42 99.54 Very High Very High Very High
sSRI 75 99.44 Very High Very High Very High
midbrain 9 99.16 Very High Very High Very High
Raphe 29 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 43 99.54 Very High Very High Very High
Depression 322 98.60 Very High Very High Very High
Stress 36 97.04 Very High Very High Very High
Anxiety Disorder 209 96.36 Very High Very High Very High
Pressure And Volume Under Development 1 95.84 Very High Very High Very High
Syndrome 8 93.28 High High
Targeted Disruption 83 89.12 High High
Urological Neuroanatomy 14 81.56 Quite High
Shock 9 79.12 Quite High
Hypertension 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate this hypothesis, we measured the effects of the antidepressant fluoxetine on neuronal levels of 5-HT1B receptor mRNA, the putative serotonin terminal autoreceptor in rat brain, and on serotonin transporter mRNA, the direct site of fluoxetine binding.
Regulation (effects) of serotonin transporter in neuronal associated with antidepressant, serotonin and fluoxetine
1) Confidence 0.45 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8914125 Disease Relevance 0.17 Pain Relevance 1.15
Investigations on the effects of serotonin (5-HT) and the serotonin transporter (5-HTT) on the pulmonary circulation are of special interest because of the reported increased risk of primary pulmonary hypertension (PPH) in patients who used some appetite suppressants that interfere with 5-HT.
Regulation (effects) of serotonin transporter associated with pressure and volume under development and serotonin
2) Confidence 0.38 Published 2002 Journal J. Lab. Clin. Med. Section Abstract Doc Link 12024106 Disease Relevance 0.23 Pain Relevance 0.20
Fluoxetine treatment to rats modifies serotonin transporter and cAMP in lymphocytes, CD4+ and CD8+ subpopulations and interleukins 2 and 4.
Regulation (modifies) of serotonin transporter in lymphocytes associated with serotonin and fluoxetine
3) Confidence 0.32 Published 2009 Journal Int. Immunopharmacol. Section Title Doc Link 19189865 Disease Relevance 0.14 Pain Relevance 0.77
Multiple kinase pathways determine serotonin transporter (SERT) regulation.
Spec (determine) Regulation (regulation) of serotonin transporter associated with serotonin
4) Confidence 0.30 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12435479 Disease Relevance 0.07 Pain Relevance 0.52
The aim of this work was to characterize the mucosal-to-serosal (apical to basolateral; AP-BL) and serosal-to-mucosal (basolateral to apical; BL-AP) transport of serotonin (5-HT) across rat jejunum, ileum, and colon, and to determine the influence of serotonin neuronal transporter inhibitors on this transport.
Spec (determine) Regulation (influence) of serotonin neuronal transporter in jejunum associated with serotonin
5) Confidence 0.24 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644933 Disease Relevance 0 Pain Relevance 0.46
Differential regulation of prodynophin, c-fos, and serotonin transporter mRNA following withdrawal from a chronic, escalating dose regimen of D-amphetamine.
Regulation (regulation) of serotonin transporter associated with enkephalin, withdrawal and serotonin
6) Confidence 0.22 Published 2009 Journal Synapse Section Title Doc Link 19116947 Disease Relevance 0.45 Pain Relevance 0.73
Fluoxetine treatment for 4 and 8, but not for 2 weeks, abolished these swim-induced changes in TPH2 and 5-HTT mRNAs levels in the midbrain and 5-HIAA content in the amygdala.
Regulation (changes) of 5-HTT in amygdala associated with midbrain, amygdala and fluoxetine
7) Confidence 0.13 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 1.12
Tryptophan hydroxylase 2 and serotonin transporter mRNAs were not significantly affected by any treatment. 5-HT(1A) mRNA levels were downregulated following i.c.v. galanin, M617 or AR-M1896 infusion.
Neg (not) Regulation (affected) of serotonin transporter associated with serotonin
8) Confidence 0.10 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18172432 Disease Relevance 0.48 Pain Relevance 1.12
Changes in the serotonin transporter (SERT) have also been reported in MDD, and changes in the immediate early gene c-fos have been observed in the context of psychostimulant withdrawal.
Regulation (Changes) of serotonin transporter associated with depression, withdrawal and serotonin
9) Confidence 0.10 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.47 Pain Relevance 0.45
The aim of this work was to characterize the mucosal-to-serosal (apical to basolateral; AP-BL) and serosal-to-mucosal (basolateral to apical; BL-AP) transport of serotonin (5-HT) across rat jejunum, ileum, and colon, and to determine the influence of serotonin neuronal transporter inhibitors on this transport.
Spec (determine) Regulation (influence) of serotonin neuronal transporter in ileum associated with serotonin
10) Confidence 0.08 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644933 Disease Relevance 0 Pain Relevance 0.46
The aim of this work was to characterize the mucosal-to-serosal (apical to basolateral; AP-BL) and serosal-to-mucosal (basolateral to apical; BL-AP) transport of serotonin (5-HT) across rat jejunum, ileum, and colon, and to determine the influence of serotonin neuronal transporter inhibitors on this transport.
Spec (determine) Regulation (influence) of serotonin neuronal transporter in colon associated with serotonin
11) Confidence 0.08 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644933 Disease Relevance 0 Pain Relevance 0.46
Fluoxetine treatment down-regulates the expression of many proteins involved in the multiple kinase pathways determining 5-HTT regulation [254] and is shown to decrease the 5-HTT expression in rat dorsal raphae nucleus [233].
Spec (determining) Regulation (regulation) of 5-HTT in dorsal associated with fluoxetine
12) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.37 Pain Relevance 0.52
The influence of genetic variation in 5-HTT and its influence on emotional traits have been recognized throwing new insights in understanding the genetic basis of depression [18, 113,114, 265].
Regulation (influence) of 5-HTT associated with depression
13) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.47 Pain Relevance 0.52
BDNF modulates 5-HTT in B-lymphocyte cell line and represents a reliable in vitro model to examine the functional regulation of 5-HTT by neurotrophins [217].
Spec (examine) Regulation (regulation) of 5-HTT in B-lymphocyte associated with bdmf
14) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.39 Pain Relevance 0.48
These results provided evidence that pro-inflammatory cytokines can acutely regulate neuronal serotonin transporter activity.
Regulation (regulate) of serotonin transporter in neuronal associated with inflammation, serotonin and cytokine
15) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.87 Pain Relevance 1.22
Since the serotonin transporter (5-HTT) is the primary target of action of SSRIs, the 5-HTT gene located on chromosome 17q12 may be a good candidate for OCD treatment.
Regulation (target) of serotonin transporter associated with anxiety disorder, ssri and serotonin
16) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.72 Pain Relevance 0.39

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