INT66318

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 26
Total Number 31
Disease Relevance 20.00
Pain Relevance 7.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
epithelial cells 3
nerve 2
hippocampus region 1
nucleus 1
monocytes 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 22 99.98 Very High Very High Very High
Glutamate 6 99.80 Very High Very High Very High
Inflammation 117 99.74 Very High Very High Very High
rheumatoid arthritis 38 99.70 Very High Very High Very High
dexamethasone 82 99.60 Very High Very High Very High
depression 197 99.10 Very High Very High Very High
antidepressant 51 99.00 Very High Very High Very High
Peripheral nerve injury 8 98.40 Very High Very High Very High
Dorsal horn 6 98.08 Very High Very High Very High
Spinal cord 6 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 127 99.74 Very High Very High Very High
Rheumatoid Arthritis 38 99.70 Very High Very High Very High
Manic Depressive Disorder 8 99.52 Very High Very High Very High
Disease 120 99.44 Very High Very High Very High
Repression 22 99.42 Very High Very High Very High
Nervous System Injury 21 99.36 Very High Very High Very High
Depression 201 99.10 Very High Very High Very High
Drug Induced Neurotoxicity 4 98.88 Very High Very High Very High
Congenital Anomalies 21 98.60 Very High Very High Very High
Neurodegenerative Disease 5 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies have shown that the glucocorticoid receptor (GR) in GCR asthmatics exhibits a lower interaction with activator protein-1 (AP-1), and this effect is accompanied by raised levels of AP-1.[26] Mathieu et al. have shown that overexpression of the GR gene in A549 human lung epithelial cells, using a GR expression vector, resulted in repression of both nuclear factor kappa-B (NF-?
Gene_expression (overexpression) of GR in epithelial cells associated with repression and occupational lung diseases
1) Confidence 0.76 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.60 Pain Relevance 0.12
Studies have shown that the glucocorticoid receptor (GR) in GCR asthmatics exhibits a lower interaction with activator protein-1 (AP-1), and this effect is accompanied by raised levels of AP-1.[26] Mathieu et al. have shown that overexpression of the GR gene in A549 human lung epithelial cells, using a GR expression vector, resulted in repression of both nuclear factor kappa-B (NF-?
Gene_expression (expression) of GR in epithelial cells associated with repression and occupational lung diseases
2) Confidence 0.66 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.55 Pain Relevance 0.12
B repression was also observed following overexpression of a GR ligand-binding mutant in the same cell line.
Gene_expression (overexpression) of GR associated with repression
3) Confidence 0.66 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.56 Pain Relevance 0.11
Studies have shown that the glucocorticoid receptor (GR) in GCR asthmatics exhibits a lower interaction with activator protein-1 (AP-1), and this effect is accompanied by raised levels of AP-1.[26] Mathieu et al. have shown that overexpression of the GR gene in A549 human lung epithelial cells, using a GR expression vector, resulted in repression of both nuclear factor kappa-B (NF-?
Gene_expression (expression) of GR in epithelial cells associated with repression and occupational lung diseases
4) Confidence 0.66 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.61 Pain Relevance 0.12
The primary genes and pathways responsible include the aromatase gene, leptin receptor gene, proopiomelanocortin (POMC) gene, serotoninergic system, and the HPA axis genes corticotrophin-releasing hormone (CRH) and the GR gene.
Gene_expression (axis) of GR
5) Confidence 0.65 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 1.51 Pain Relevance 0.05
Relative amounts of GRalpha and GRbeta
Gene_expression (amounts) of GRbeta
6) Confidence 0.63 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.53 Pain Relevance 0.13
Functional analyses of GRbeta
Spec (analyses) Gene_expression (analyses) of GRbeta
7) Confidence 0.63 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.67 Pain Relevance 0.04
Relative amounts of GRalpha and GRbeta
Gene_expression (amounts) of GRalpha
8) Confidence 0.63 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.53 Pain Relevance 0.13
B repression to be strictly hormone dependent.[28] These findings suggest that overexpression of the GR in vivo may be a potentially useful approach to gene therapy, especially as a complimentary or alternative treatment for GCR asthmatics.
Gene_expression (overexpression) of GR associated with repression and occupational lung diseases
9) Confidence 0.59 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.57 Pain Relevance 0.11
Schwann cells of the peripheral nerves express glucocorticoid receptors (GR), and glucocorticoids enhance the rate of myelin formation in vitro.
Gene_expression (express) of GR in peripheral nerves
10) Confidence 0.59 Published 2010 Journal Glia Section Abstract Doc Link 20169622 Disease Relevance 0.55 Pain Relevance 0.26
Immunohistochemistry showed that the nuclei of in vivo Schwann cells expressed GR and that glucocorticoids impacted the GR immunoreactivity of the Schwann cells.
Gene_expression (expressed) of GR in Schwann cells
11) Confidence 0.59 Published 2010 Journal Glia Section Abstract Doc Link 20169622 Disease Relevance 0.54 Pain Relevance 0.22
However, the relationship between the expression of spinal GR and CB1R after nerve injury remains unclear.
Gene_expression (expression) of GR in nerve associated with nervous system injury
12) Confidence 0.53 Published 2007 Journal Pain Section Abstract Doc Link 17258396 Disease Relevance 0.60 Pain Relevance 0.41
5% were selected for CRH, CRHBP, CRHR1, POMC, MC2R, NR3C1 and SERPINA6 and their 10 kb flanking regions using Tagger.24 SNPs were genotyped using Sequenom MassARRAY technology following the manufacturer's instructions (http://www.sequenom.com).
Gene_expression (selected) of NR3C1
13) Confidence 0.31 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2927682 Disease Relevance 0.56 Pain Relevance 0.14
In transient transfections which included the PPE-CAT reporter gene and a glucocorticoid receptor expression plasmid, dexamethasone significantly reduced stimulated expression of the reporter by TPA, forskolin, and A23187.
Gene_expression (expression) of glucocorticoid receptor associated with dexamethasone
14) Confidence 0.30 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8915585 Disease Relevance 0 Pain Relevance 0.33
However, the relationship between the expression of spinal GR and glutamate transporter after nerve injury remains unknown.
Gene_expression (expression) of GR in nerve associated with glutamate and nervous system injury
15) Confidence 0.28 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.51 Pain Relevance 0.42
Chronic stress can also result in decreased neurogenesis (nerve cell growth).47 Brain imaging studies show structural brain changes (eg, atrophy or enlarged ventricles) in patients with mood disorders, and this may partly reflect stress-induced neurotoxicity or the inhibition of neurogenesis.44,48 Many antidepressant drugs have the effect of reducing neurotoxicity or enhancing neurogenesis.44 Similarly, agomelatine increases neurogenesis in the hippocampus region of the brain and may also have neuroprotective effects.49,50 The effects on neurogenesis and neurotoxicity are mediated in part by influencing glutamate release, glucocorticoid receptor gene expression, and various neurotrophic factors.51–55

Pharmacokinetic profile of agomelatine

Gene_expression (expression) of glucocorticoid receptor in hippocampus region associated with stress, glutamate, antidepressant, drug induced neurotoxicity, affective disorder, frailty, hippocampus, neurodegenerative disease and imagery
16) Confidence 0.15 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 1.53 Pain Relevance 0.32
In female patients with early-diagnosed RA a decrease in glucocorticoid receptor expression was found as well as a decrease in cortisol levels.
Gene_expression (expression) of glucocorticoid receptor associated with rheumatoid arthritis
17) Confidence 0.12 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114259 Disease Relevance 0.83 Pain Relevance 0.45
Since normal glucocorticoid receptor expression was found in the male population with early-diagnosed RA, it remains questionable if glucocorticoid receptor expression is causally involved in pathogenesis of RA.
Gene_expression (expression) of glucocorticoid receptor associated with rheumatoid arthritis
18) Confidence 0.12 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114259 Disease Relevance 0.81 Pain Relevance 0.40
Since normal glucocorticoid receptor expression was found in the male population with early-diagnosed RA, it remains questionable if glucocorticoid receptor expression is causally involved in pathogenesis of RA.
Gene_expression (expression) of glucocorticoid receptor associated with rheumatoid arthritis
19) Confidence 0.12 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114259 Disease Relevance 0.89 Pain Relevance 0.44
Steroid resistance also has been reported for the activation of T cells and monocytes in MD and bipolar disorder, suggesting comparable glucocorticoid receptor impairment in immune and CNS cells.
Neg (impairment) Gene_expression (impairment) of glucocorticoid receptor in T cells associated with manic depressive disorder, depression and central nervous system
20) Confidence 0.12 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2847693 Disease Relevance 0.76 Pain Relevance 0.51

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