INT66332

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 46
Disease Relevance 40.09
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
BAT 5
liver 2
body 2
brown fat 1
fat 1
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 76 99.84 Very High Very High Very High
tolerance 179 99.66 Very High Very High Very High
Catecholamine 2 94.48 High High
Clonidine 6 89.64 High High
Glutamate 32 87.48 High High
Eae 42 79.84 Quite High
headache 1 69.96 Quite High
Dopamine 1 61.92 Quite High
cytokine 8 55.52 Quite High
cerebral cortex 7 54.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 2607 100.00 Very High Very High Very High
Diabetes Mellitus 108 99.60 Very High Very High Very High
Hypoxia 398 99.16 Very High Very High Very High
Hyperlipidemia 27 99.04 Very High Very High Very High
Cancer 758 98.72 Very High Very High Very High
Impaired Glucose Tolerance 132 96.64 Very High Very High Very High
Insulin Resistance 137 94.76 High High
Apnoea 28 94.68 High High
Targeted Disruption 265 91.08 High High
Body Weight 404 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of UCP-1 mRNA was significantly increased in WAT in the HF + BOF group, but there was little expression of UCP-1 mRNA in the BD, HF, or HF + DAI groups (Fig. 3B).
Gene_expression (expression) of UCP-1 mRNA associated with obesity
1) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.20 Pain Relevance 0.04
There were no significant differences in UCP-1 mRNA expression of BAT among the four groups (Fig. 3A).
Gene_expression (expression) of UCP-1 mRNA associated with obesity
2) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.26 Pain Relevance 0.04
However, there was no significant difference in UCP1 mRNA expression of BAT among the four groups in this study.
Gene_expression (expression) of UCP1 mRNA associated with obesity
3) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.20 Pain Relevance 0.07
However, if the expression of UCP1 can be activated in tissues other than BAT by Kampo ingredients, this could constitute a good therapy for obesity.
Gene_expression (expression) of UCP1 associated with obesity
4) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.26 Pain Relevance 0.07
Further studies are needed to evaluate the effect of BOF on thermogenesis and UCP1 expression in human WAT.



Gene_expression (expression) of UCP1 associated with obesity
5) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 0.92 Pain Relevance 0.11
Indeed, UCP1 expression in WAT can lead to an increase in energy expenditure via the generation of heat.
Gene_expression (expression) of UCP1 associated with obesity
6) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.57 Pain Relevance 0.08
UCP-1 expression in BAT is known to be a significant component of whole body energy expenditure and its dysfunction contributes to the development of obesity [15].
Gene_expression (expression) of UCP-1 in body associated with obesity
7) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.82 Pain Relevance 0.11
The expression of UCP-1 mRNA was significantly increased in WAT in the HF + BOF group, but there was little expression of UCP-1 mRNA in the BD, HF, or HF + DAI groups (Fig. 3B).
Gene_expression (expression) of UCP-1 mRNA associated with obesity
8) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.13 Pain Relevance 0.04
Therefore, several studies have shown that _3-adrenoreceptor agonists and some dietary constituents induce expression of UCP1 not only in BAT, but also in WAT [16–18].
Gene_expression (expression) of UCP1 associated with obesity and agonist
9) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.58 Pain Relevance 0.09
UCP1 expression in BAT is also known as a significant component of whole body energy expenditure and its dysfunction contributes to the development of obesity [15].
Gene_expression (expression) of UCP1 in body associated with obesity
10) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.11 Pain Relevance 0.05
In the present study, UCP1 mRNA in WAT was barely detectable in the BD and HF groups, whereas significant expression was found in the HF + BOF group.
Gene_expression (detectable) of UCP1 mRNA associated with obesity
11) Confidence 0.75 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.30 Pain Relevance 0.08
As shown in Fig. 3, the gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Gene_expression (expression) of Ucp-1 associated with obesity
12) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.57 Pain Relevance 0
Immunohistological analyses showed a high expression of Ucp-1 and Ucp-3 in BAT in all experimental groups.
Gene_expression (expression) of Ucp-1 associated with obesity
13) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.43 Pain Relevance 0
mRNA expression of UCP1 and UCP2 in WAT and BAT
Gene_expression (expression) of UCP1 associated with obesity
14) Confidence 0.65 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.32 Pain Relevance 0.03
-3 adrenoreceptor agonists induce expression of UCP1 not only in BAT, but also WAT.
Gene_expression (expression) of UCP1 associated with obesity and agonist
15) Confidence 0.65 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.37 Pain Relevance 0.11
In conclusion, we found that a diet supplemented with BOF inhibited the visceral fat accumulation in high-fat diet-fed mice, and that BOF induced gene expression of UCP1, which regulates energy metabolism in WAT.
Gene_expression (expression) of UCP1 in fat associated with obesity
16) Confidence 0.65 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.28 Pain Relevance 0.15
BAT is a thermogenic organ in which increased expression of UCP1 decreases mitochondrial energy efficiency, leading to the generation of heat [17].
Gene_expression (expression) of UCP1
17) Confidence 0.64 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0 Pain Relevance 0
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Gene_expression (expression) of UCP1
18) Confidence 0.64 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
BAT produces heat through the action of uncoupling protein 1 (UCP1) [6].
Gene_expression (produces) of uncoupling protein 1 in BAT associated with obesity
19) Confidence 0.62 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2970595 Disease Relevance 2.33 Pain Relevance 0.05
BAT produces heat through the action of uncoupling protein 1 (UCP1) [6].
Gene_expression (produces) of UCP1 in BAT associated with obesity
20) Confidence 0.62 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2970595 Disease Relevance 2.39 Pain Relevance 0.05

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