INT6635

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.85
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cnp) plasma membrane (Cnp) intracellular (Cnp)
cytoplasm (Cnp)
Anatomy Link Frequency
spinal cord 1
muscle 1
smooth muscle tissue 1
neural 1
Cnp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 67 99.40 Very High Very High Very High
dopamine receptor 1 99.20 Very High Very High Very High
Dopamine 13 99.12 Very High Very High Very High
antagonist 8 99.04 Very High Very High Very High
opiate 2 98.60 Very High Very High Very High
GABA receptor 2 96.52 Very High Very High Very High
Morphine 1 90.96 High High
Catecholamine 4 82.16 Quite High
tetrodotoxin 1 82.08 Quite High
Neuritis 2 81.16 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 6 99.86 Very High Very High Very High
Diabetes Mellitus 82 99.12 Very High Very High Very High
Bronchospasm 1 98.32 Very High Very High Very High
Immunization 1 96.36 Very High Very High Very High
Weight Loss 1 95.68 Very High Very High Very High
Middle Cerebral Artery Infarction 14 95.56 Very High Very High Very High
Disease 3 95.20 Very High Very High Very High
Reprotox - General 2 144 93.68 High High
Paralysis 2 91.84 High High
Natriuresis 13 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aminophylline, an inhibitor of cyclic nucleotide phosphodiesterase, has for many years been used to relieve bronchospasm.
Negative_regulation (inhibitor) of cyclic nucleotide phosphodiesterase associated with bronchospasm
1) Confidence 0.57 Published 1987 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3296607 Disease Relevance 0.41 Pain Relevance 0.09
The activity of the myelin marker enzyme CNPase was markedly decreased in the lumbar spinal cord of encephalitogen-immunized animals on day 16 (ie 16 days after immunization) and the decrease of enzymatic activity was partially prevented by GrS administration.
Negative_regulation (decreased) of CNPase in spinal cord associated with immunization and spinal cord
2) Confidence 0.50 Published 1990 Journal Jpn. J. Ophthalmol. Section Abstract Doc Link 1706788 Disease Relevance 0.76 Pain Relevance 0.27
Inhibition of cyclic nucleotide phosphodiesterase prior to addition of dopamine enhanced the effect of this amine to decrease baseline muscle tension. 4.
Negative_regulation (Inhibition) of cyclic nucleotide phosphodiesterase in muscle associated with dopamine
3) Confidence 0.48 Published 1992 Journal J. Comp. Physiol. A Section Abstract Doc Link 1331434 Disease Relevance 0 Pain Relevance 0.69
In contrast to the loss of CNPase immunoreactivity, there were many NG2 positive cells in the ischemic boundary region and the SVZ 7 days after MCAo (Fig. 2I-L).
Negative_regulation (loss) of CNPase associated with middle cerebral artery infarction
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.32 Pain Relevance 0.04
Since CNP may be a regulator of vascular function, a vasopeptidase inhibitor may be an effective treatment for diabetes-induced vascular and neural disease.
Negative_regulation (regulator) of CNP in neural associated with diabetes mellitus and disease
5) Confidence 0.36 Published 2007 Journal Diabetes Section Abstract Doc Link 17259379 Disease Relevance 1.02 Pain Relevance 0.05
The inhibitory effect of CNP on spontaneous contraction revealed a dose-dependency, and the inhibitory percentages were 25.5 +/- 1.7%, 43.6 +/- 3.2%, 85.1 +/- 2.5% in diabetic rats and 20.5 +/- 1.5%, 31.1 +/- 1.7%, 58.9 +/- 3.7% in the control group at the concentrations of 0.01, 0.03, and 0.1 mumol/l, respectively.
Negative_regulation (effect) of CNP associated with diabetes mellitus
6) Confidence 0.36 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.64 Pain Relevance 0.13
The 'anxiolytic-like' effect of CNP was prevented by a dopamine receptor antagonist, or an alpha- or beta-adrenoreceptor blocker but not by a muscarinergic cholinergic blocker, a GABA receptor, a 5-HT receptor antagonist or an opiate receptor antagonist.
Negative_regulation (effect) of CNP associated with gaba receptor, antagonist, dopamine receptor, anxiety disorder and opiate
7) Confidence 0.28 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8868301 Disease Relevance 0.69 Pain Relevance 0.76
The western blot analysis showing progressive decrease in levels of cellular markers (CNPase, NSE and PGP9.5) up to 4 weeks is likely to reflect the clearance of non-cell associated markers.
Negative_regulation (decrease) of CNPase
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2918504 Disease Relevance 0.48 Pain Relevance 0
These experiments led to our published hypothesis that sialorphin in corporal smooth muscle tissue can induce relaxation through its action as an NEP inhibitor, preventing the breakdown of CNP bound to receptors.[63]
Negative_regulation (breakdown) of CNP in smooth muscle tissue
9) Confidence 0.13 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.52 Pain Relevance 0.12

General Comments

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