INT66365

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Context Info
Confidence 0.07
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
nucleus 2
spinal cord 1
bladder 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Spinal cord 2 99.60 Very High Very High Very High
Intracerebroventricular 2 99.32 Very High Very High Very High
narcan 4 98.86 Very High Very High Very High
interstitial cystitis 2 98.16 Very High Very High Very High
Opioid 1 92.72 High High
antagonist 2 92.44 High High
cytokine 1 87.40 High High
nMDA receptor 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 2 99.06 Very High Very High Very High
Interstitial Cystitis 2 98.16 Very High Very High Very High
Apoptosis 4 95.44 Very High Very High Very High
Stress 5 94.64 High High
Hypoxia 144 93.40 High High
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 4 5.00 Very Low Very Low Very Low
Retinal Diseases 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular administration of beta-endorphin increases the expression of c-fos and of corticotropin-releasing factor messenger ribonucleic acid in the paraventricular nucleus of the rat.
Positive_regulation (increases) of Gene_expression (expression) of factor in nucleus associated with intracerebroventricular
1) Confidence 0.07 Published 1996 Journal Brain Res. Section Title Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.40
Many of the genes known to be directly transactivated by the overexpression of the transcription co-factor HIF-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of factor
2) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.61 Pain Relevance 0.04
INTRODUCTION: We investigated the effect of interstitial cystitis (IC) urine on bladder layers and nociceptive centers in the spinal cord with determination of nerve growth factor (NGF), neuronal nitric oxide synthase (nNOS) and c-fos expressions.
Spec (determination) Positive_regulation (determination) of in spinal cord Gene_expression (expressions) of factor in bladder associated with nociception, nerve growth factor, interstitial cystitis, neuronal nitric oxide synthase and spinal cord
3) Confidence 0.01 Published 2003 Journal Urol. Int. Section Abstract Doc Link 12845264 Disease Relevance 0.35 Pain Relevance 0.36

General Comments

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