INT66366

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 6.56
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
brain 2
neuronal 1
Notch 1
spinal cord 1
cerebral spinal fluid 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 57 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Hippocampus 32 99.86 Very High Very High Very High
antagonist 83 99.82 Very High Very High Very High
Opioid 21 99.60 Very High Very High Very High
Spinal cord 2 99.60 Very High Very High Very High
narcan 4 99.38 Very High Very High Very High
Glutamate 31 99.12 Very High Very High Very High
depression 88 98.46 Very High Very High Very High
Intracerebroventricular 4 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 151 100.00 Very High Very High Very High
Leukemia 2 100.00 Very High Very High Very High
Cholestasis 33 99.86 Very High Very High Very High
Injury 27 99.22 Very High Very High Very High
Nociception 2 99.06 Very High Very High Very High
Depression 76 98.46 Very High Very High Very High
Major Depressive Disorder 16 98.20 Very High Very High Very High
Interstitial Cystitis 2 98.16 Very High Very High Very High
Infection 66 96.92 Very High Very High Very High
Cancer 52 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence suggests that glycogen synthase kinase-3beta (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD).
Positive_regulation (increased) of glycogen synthase kinase-3beta in brain associated with major depressive disorder
1) Confidence 0.68 Published 2008 Journal Pharmacogenomics J. Section Abstract Doc Link 18195729 Disease Relevance 0.47 Pain Relevance 0.22
Evidence suggests that glycogen synthase kinase-3beta (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD).
Positive_regulation (increased) of GSK3B in brain associated with major depressive disorder
2) Confidence 0.68 Published 2008 Journal Pharmacogenomics J. Section Abstract Doc Link 18195729 Disease Relevance 0.47 Pain Relevance 0.22
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Positive_regulation (mediator) of GSK-3 beta associated with opioid
3) Confidence 0.38 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.77
At 5 minutes of reperfusion, both MOR and BW increased P-GSKbeta at Ser9 in the ischemic zone compared with vehicle (181+/-20, 178+/-15 versus 75+/-17 DU, respectively; P<0.05), and this effect was abrogated by prior administration of wortmannin or rapamycin in MOR-treated rats.
Positive_regulation (increased) of GSKbeta
4) Confidence 0.30 Published 2004 Journal Circ. Res. Section Abstract Doc Link 14976126 Disease Relevance 0.23 Pain Relevance 0.44
In vitro it has been shown, that glucocorticoids inhibit wnt signalling by activating glycogen synthase kinase 3 beta (GSK3?)
Positive_regulation (activating) of glycogen synthase kinase 3 beta
5) Confidence 0.23 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.63 Pain Relevance 0.27
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Positive_regulation (pathway-dependent) of GSK-3 beta
6) Confidence 0.17 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.41
As for lithium-specific effects, the most significant altered expressions were reported for the BCL-2 associated X protein (BAX) and the platelet-activating factor acetylhydrolase isoform 1b, beta subunit (PAFAH1B2).

3.2.

Positive_regulation (activating) of factor in platelet
7) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.06 Pain Relevance 0
We evaluated the effects of intracerebroventricular (i.c.v.) administration of beta-endorphin and naloxone, an opioid antagonist, on the induction of c-fos and corticotropin-releasing factor (CRF) mRNA to clarify the effects of beta-endorphin on cellular activity and CRF gene expression in the paraventricular nucleus (PVN) of the rat using in situ hybridization.
Positive_regulation (induction) of factor in PVN associated with antagonist, narcan, opioid and intracerebroventricular
8) Confidence 0.11 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.35
In contrast, isoproterenol (ISO) (0.01-10 mg/kg i.g.), beta-adrenoceptor agonist, reduced dose-dependently ethanol-induced mucosal injury and this effect was accompanied by an elevation of the GBF similarly as after epidermal growth factor (EGF) (100 microg/kg x h s.c.) or after classic protective agent, 16,16-dimethyl-PGE2 (PGE2) (10 microg/kg i.g.).
Positive_regulation (elevation) of factor associated with injury and agonist
9) Confidence 0.05 Published 1997 Journal Digestion Section Abstract Doc Link 9324159 Disease Relevance 0.10 Pain Relevance 0.41
Moreover, estrogens play a role in activation of the molecular cascade involved in plastic adjustment of cellular functions inducing c-Fos expression (one of the first signs of neuronal plasticity) in the hippocampus [22], activate MAP-kinase (a growth factor) [23] and potentiate glutamate binding to N-methyl-d-aspartate (NMDA) receptors [20,21].
Positive_regulation (activate) of factor in neuronal associated with glutamate and hippocampus
10) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.33 Pain Relevance 0.29
Another important molecule, the transcription factor hypoxia inducible factor-1 (HIF-1), is well established as a key molecular signal linking oxygen level to gene expression in many tissues.
Positive_regulation (inducible) of factor associated with hypoxia
11) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.52 Pain Relevance 0
These findings include elevated basal levels of serum cortisol, increased corticotrophin-releasing factor in cerebral spinal fluid [136–138], and disruption of negative feedback mechanisms [139].
Positive_regulation (increased) of factor in cerebral spinal fluid
12) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.26 Pain Relevance 0.09
Depression of cholangiocyte mitochondrial respiration in obstructive cholestasis could induce hypoxia-inducible factor (HIF)1?
Positive_regulation (induce) of factor associated with cholestasis, depression and hypoxia
13) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.84 Pain Relevance 0.19
INTRODUCTION: We investigated the effect of interstitial cystitis (IC) urine on bladder layers and nociceptive centers in the spinal cord with determination of nerve growth factor (NGF), neuronal nitric oxide synthase (nNOS) and c-fos expressions.
Spec (determination) Positive_regulation (determination) of factor in spinal cord associated with nociception, nerve growth factor, interstitial cystitis, neuronal nitric oxide synthase and spinal cord
14) Confidence 0.01 Published 2003 Journal Urol. Int. Section Abstract Doc Link 12845264 Disease Relevance 0.35 Pain Relevance 0.36
At that time the factor(s) was called ‘glucocorticoid-increasing factor’.
Positive_regulation (increasing) of factor
15) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.85 Pain Relevance 0.24
According to this view, SP cells/nestin-positive cells may play a role in local homeostasis and tissue remodelling, particularly because their number increases in response to various growth factors, such as leukaemia-inhibitory factor (LIF), FGF-2 and EGF, and in response to activating the Notch pathway (658), and as in aggregate cell culture nestin-positive cells organise in a network with long cellular extensions (648).
Positive_regulation (increases) of factor in Notch associated with leukemia
16) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.10 Pain Relevance 0

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