INT66367

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.75
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
myocytes 1
smooth muscle 1
brain 1
pituitary 1
bladder 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Nerve growth factor 57 99.84 Very High Very High Very High
Intracerebroventricular 4 99.04 Very High Very High Very High
Spinal cord 2 99.00 Very High Very High Very High
fibrosis 114 98.76 Very High Very High Very High
narcan 4 98.58 Very High Very High Very High
interstitial cystitis 2 97.56 Very High Very High Very High
metalloproteinase 26 96.68 Very High Very High Very High
Opioid 7 92.72 High High
antagonist 86 92.44 High High
Disease Link Frequency Relevance Heat
Schizophrenia 221 99.10 Very High Very High Very High
Fibrosis 104 98.76 Very High Very High Very High
Nociception 2 98.46 Very High Very High Very High
Congenital Anomalies 44 98.42 Very High Very High Very High
Disease 129 97.68 Very High Very High Very High
Interstitial Cystitis 2 97.56 Very High Very High Very High
Adhesions 24 95.68 Very High Very High Very High
Apoptosis 40 95.44 Very High Very High Very High
Stress 140 94.64 High High
Ureteral Obstruction 8 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through phosphatidylinositol-3 kinase (PI3K).
Gene_expression (produced) of Glycogen synthase kinase
1) Confidence 0.45 Published 2004 Journal Circ. Res. Section Abstract Doc Link 14976126 Disease Relevance 0.05 Pain Relevance 0.38
Glycogen synthase kinase 3 beta (GSK-3beta) was one of the first kinases identified and studied, initially for its role in the regulation of glycogen synthesis.
Gene_expression (one) of Glycogen synthase kinase 3 beta
2) Confidence 0.19 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.28 Pain Relevance 0
Glycogen synthase kinase 3 beta (GSK-3beta) was one of the first kinases identified and studied, initially for its role in the regulation of glycogen synthesis.
Gene_expression (one) of GSK-3beta
3) Confidence 0.19 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.28 Pain Relevance 0
These experiments confirm that inhibition of GSK3 beta protects the myocytes, but also that the preconditioning mimetic DADLE loses its protective effect when a constitutively active GSK3 beta is present.
Gene_expression (present) of GSK3 beta in myocytes
4) Confidence 0.17 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20337662 Disease Relevance 0.29 Pain Relevance 0.13
Again, several of the protein products for Reelin, Vldlr, Dab-1, Gsk3 beta, Gad65, and Gad67 were also significantly altered by multiple drugs.
Gene_expression (products) of Gsk3 beta
5) Confidence 0.16 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.34 Pain Relevance 0.22
Intracerebroventricular administration of beta-endorphin increases the expression of c-fos and of corticotropin-releasing factor messenger ribonucleic acid in the paraventricular nucleus of the rat.
Gene_expression (expression) of factor in nucleus associated with intracerebroventricular
6) Confidence 0.09 Published 1996 Journal Brain Res. Section Title Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.40
They suggest that SMF could modulate BMD via a reactive oxygen species- (ROS-) dependent upregulation of vascular endothelial growth factor (VEGF) expression [29].
Gene_expression (expression) of factor
7) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.35 Pain Relevance 0.11
Many of the genes known to be directly transactivated by the overexpression of the transcription co-factor HIF-1?
Gene_expression (overexpression) of factor
8) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.61 Pain Relevance 0.04
eNOS generates physiological levels of nitric oxide (NO), a potent vasodilator [40] and antiapoptotic factor [41, 42].
Gene_expression (generates) of factor
9) Confidence 0.02 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.82 Pain Relevance 0.03
INTRODUCTION: We investigated the effect of interstitial cystitis (IC) urine on bladder layers and nociceptive centers in the spinal cord with determination of nerve growth factor (NGF), neuronal nitric oxide synthase (nNOS) and c-fos expressions.
Gene_expression (expressions) of factor in bladder associated with nociception, nerve growth factor, interstitial cystitis, neuronal nitric oxide synthase and spinal cord
10) Confidence 0.01 Published 2003 Journal Urol. Int. Section Abstract Doc Link 12845264 Disease Relevance 0.35 Pain Relevance 0.36
In fibrosis, the positive balance to collagen synthesis is influenced by production of transforming growth factor TGF?
Gene_expression (production) of factor associated with fibrosis
11) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 2.16 Pain Relevance 0.65
-smooth muscle actin and connective tissue growth factor protein expression, although synthesis of collagen was unaffected by PFD [56].


Gene_expression (expression) of factor in smooth muscle
12) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.40 Pain Relevance 0.18
The Zic2kd/+ mouse is an animal model for diseases of sensorimotor gating abnormalities which would include schizophrenia.215 Chronic and prenatal BPA exposures both produce a significant decrease and disruption of SH.175

Glial Cell LineĀ–Derived Neurotrophic Factor.

Gene_expression (produce) of Factor associated with congenital anomalies, disease and schizophrenia
13) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.79 Pain Relevance 0.14
Moreover, the same paracrine factor can be expressed in different cell types, but the change in its expression occurs only in the cell type that is relevant for supporting the changing pituitary function.
Gene_expression (expressed) of factor in pituitary
14) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.04
Moreover, it processes perlecan to produce a potent anti-angiogenic factor.
Gene_expression (produce) of factor
15) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.52 Pain Relevance 0.19
Also ibuprofen, a non-selective COX-inhibitor, caused memory consolidation deficits in this experimental setting, which was associated with decreased expression of brain-derived growth factor (BDNF) [47].
Gene_expression (expression) of factor in brain
16) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866462 Disease Relevance 0.53 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox