INT6637

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Context Info
Confidence 0.10
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Avpr2) signal transducer activity (Avpr2)
Avpr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 99.96 Very High Very High Very High
bradykinin 1 79.60 Quite High
Potency 1 69.00 Quite High
Dismenorea 1 58.64 Quite High
carbamazepine 22 52.36 Quite High
headache 6 35.84 Quite Low
sSRI 6 5.00 Very Low Very Low Very Low
Trigeminal neuralgia 4 5.00 Very Low Very Low Very Low
Endep 4 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyponatremia 73 92.84 High High
Leukemia 1 84.04 Quite High
Disease 2 65.72 Quite High
Confusion 4 59.76 Quite High
Dysmenorrhea 1 58.64 Quite High
Asymptomatic Diseases 1 47.32 Quite Low
Hypernatremia 1 41.76 Quite Low
Amnesia 1 38.32 Quite Low
Vomiting 5 36.16 Quite Low
Headache 10 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, this class exhibited good selectivity for binding to the oxytocin receptor versus the arginine vasopressin V1a and V2 receptor subtypes, although increased V2 receptor affinity was observed in one case (32, cyclo[L-prolyl-D-2-naphthylalanyl-L-isoleucyl-D-pipecolyl-L- lysyl-D-(N- methyl)phenylalanyl]).
Positive_regulation (increased) of V2 receptor
1) Confidence 0.10 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1331448 Disease Relevance 0.06 Pain Relevance 0.24
A role for the new selective vasopressin V2-receptor antagonists in these clinical examples is not difficult to imagine.
Positive_regulation (selective) of V2-receptor associated with antagonist
2) Confidence 0.05 Published 2009 Journal NDT Plus Section Body Doc Link PMC2762828 Disease Relevance 0.96 Pain Relevance 0.10

General Comments

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