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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, Crh) extracellular space (Pomc, Crh) extracellular region (Pomc, Crh)
response to stress (Crh) cell-cell signaling (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
brain 2
Pomc (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 100.00 Very High Very High Very High
Hippocampus 2 98.28 Very High Very High Very High
antagonist 1 98.22 Very High Very High Very High
narcan 4 97.78 Very High Very High Very High
Intracerebroventricular 3 96.68 Very High Very High Very High
Enkephalin 1 81.12 Quite High
Potency 1 78.56 Quite High
Endogenous opioid 1 72.96 Quite High
Neuropeptide 1 54.24 Quite High
opioid receptor 1 27.04 Quite Low


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the effects of intracerebroventricular (i.c.v.) administration of beta-endorphin and naloxone, an opioid antagonist, on the induction of c-fos and corticotropin-releasing factor (CRF) mRNA to clarify the effects of beta-endorphin on cellular activity and CRF gene expression in the paraventricular nucleus (PVN) of the rat using in situ hybridization.
beta-endorphin Regulation (effects) of Gene_expression (expression) of CRF gene in PVN associated with antagonist, narcan, opioid and intracerebroventricular
1) Confidence 0.49 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.35
Anti-beta-endorphin IgG down-regulated ET-A receptor protein expression in the caudate (51%), but had no effect on the expression of mu, delta, kappa opioid, ET-B, CRH-1 and CRH-2 receptors in any brain region.
beta-endorphin Neg (no) Regulation (effect) of Gene_expression (expression) of CRH in brain associated with opioid
2) Confidence 0.33 Published 2006 Journal Peptides Section Abstract Doc Link 16165252 Disease Relevance 0 Pain Relevance 0.53

General Comments

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