INT6638

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Context Info
Confidence 0.34
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 1.52
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
nucleus accumbens 1
endometrium 1
ventral 1
ovary 1
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 150 100.00 Very High Very High Very High
Nucleus accumbens 8 99.70 Very High Very High Very High
tetrodotoxin 1 98.08 Very High Very High Very High
agonist 87 96.68 Very High Very High Very High
Potency 2 96.32 Very High Very High Very High
vagus nerve 1 94.24 High High
Peripheral nervous system 3 90.88 High High
Neuropeptide 26 89.88 High High
medulla 1 89.52 High High
Central nervous system 3 88.36 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 9 96.28 Very High Very High Very High
Intellectual Impairment 6 95.84 Very High Very High Very High
Targeted Disruption 30 80.96 Quite High
Dysmenorrhea 10 80.48 Quite High
Autism 18 79.68 Quite High
Phobia 3 79.24 Quite High
Nociception 9 74.40 Quite High
Pain 16 73.32 Quite High
Obsessive-compulsive Disorder 3 69.52 Quite High
Stress 36 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 1 competitively inhibits binding of [3H]oxytocin and the peptide antagonist 125I-ornithine vasotocin analog to human and rat oxytocin receptor expressed in human embryonic kidney 293-EBNA or Chinese hamster ovary cells with nanomolar potency.
oxytocin receptor Binding (binding) of in ovary associated with antagonist and potency
1) Confidence 0.34 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660315 Disease Relevance 0 Pain Relevance 0.22
By contrast, beta-arrestin/OTR interactions initiated only at 10 sec, reached plateau levels at 120 sec, but remained stable with little decrease thereafter.
OTR Binding (interactions) of
2) Confidence 0.23 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.08 Pain Relevance 0.16
Physical GRK2/OTR association was further demonstrated by coimmunoprecipitation of endogenous GRK2 with activated OTR.
OTR Binding (association) of
3) Confidence 0.23 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.07 Pain Relevance 0.15
In addition, not only the hormone itself and its binding to OTR, but also its synthesis, storage and release can be endogenously and exogenously regulated to counteract pathophysiological states.
OTR Binding (binding) of
4) Confidence 0.23 Published 2010 Journal CNS Neuroscience & Therapeutics Section Abstract Doc Link PMC2972642 Disease Relevance 0.50 Pain Relevance 0.26
Using bioluminescence resonance energy transfer (BRET) techniques, Zingg's group was able to demonstrate that the oxytocin receptor interacts with other GPCRs coexpressed in myometrial cells [161].
oxytocin receptor Binding (interacts) of
5) Confidence 0.23 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.17
The second messenger activated by oxytocin receptor binding is, however, not yet known.
oxytocin receptor Binding (binding) of
6) Confidence 0.22 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9517466 Disease Relevance 0 Pain Relevance 0.27
They could associate oxytocin receptor haplotypes with affect regulation, social interaction (social and emotional loneliness) and cognition (intelligence) [40].
oxytocin receptor Binding (associate) of associated with cognitive disorder and intellectual impairment
7) Confidence 0.20 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.74 Pain Relevance 0.06
By contrast, specific inhibition of endogenous GRK2 by dominant-negative mutants robustly inhibited OTR phosphorylation and internalization as well as arrestin/OTR interactions.
OTR Binding (interactions) of
8) Confidence 0.18 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.06
These data characterize the temporal and causal relationship of GRK-2/OTR and beta-arrestin/OTR interactions and establish GRK/OTR interaction as a prerequisite for beta-arrestin-mediated OTR desensitization.
OTR Binding (interactions) of
9) Confidence 0.18 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.03
These data characterize the temporal and causal relationship of GRK-2/OTR and beta-arrestin/OTR interactions and establish GRK/OTR interaction as a prerequisite for beta-arrestin-mediated OTR desensitization.
OTR Binding (interactions) of
10) Confidence 0.18 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.03
These data characterize the temporal and causal relationship of GRK-2/OTR and beta-arrestin/OTR interactions and establish GRK/OTR interaction as a prerequisite for beta-arrestin-mediated OTR desensitization.
OTR Binding (interaction) of
11) Confidence 0.18 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.03
To delineate more clearly the neuroanatomical boundaries of the OTR and V1aR fields in this species, we compared OTR and V1aR binding in adjacent brain sections and also with markers that delineate neuroanatomical boundaries in the ventral forebrain.
OTR Binding (binding) of in ventral
12) Confidence 0.18 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689486 Disease Relevance 0 Pain Relevance 0.18
A relatively low dose of OTA was chosen because the antagonist binds OTR more effectively than OT, with an affinity for OTR greater than 10 times that of the natural ligand [32] and this same dose has been used in multiple other studies [2,3,7,9].
OTR Binding (affinity) of associated with antagonist
13) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0 Pain Relevance 0.29
Furthermore, destruction of ventral striatal dopaminergic terminals with 6-hydroxydopamine infusions into the nucleus accumbens did not alter OTR binding.
OTR Binding (binding) of in nucleus accumbens associated with nucleus accumbens
14) Confidence 0.15 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689486 Disease Relevance 0 Pain Relevance 0.31
In general, this class exhibited good selectivity for binding to the oxytocin receptor versus the arginine vasopressin V1a and V2 receptor subtypes, although increased V2 receptor affinity was observed in one case (32, cyclo[L-prolyl-D-2-naphthylalanyl-L-isoleucyl-D-pipecolyl-L- lysyl-D-(N- methyl)phenylalanyl]).
oxytocin receptor Binding (binding) of
15) Confidence 0.12 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1331448 Disease Relevance 0.05 Pain Relevance 0.22
RESULTS: Compared with normal endometrium, immunoreactivity of OTR and TRPV1 were significantly increased in ectopic endometrium.
OTR Binding (immunoreactivity) of in endometrium
16) Confidence 0.09 Published 2010 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 20096818 Disease Relevance 0.08 Pain Relevance 0

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