INT66381

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 6
Speculated 12
Reported most in Abstract
Documents 40
Total Number 52
Disease Relevance 13.38
Pain Relevance 27.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
brain 4
spinal cord 2
spinal 2
medulla 1
tail 1
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 198 100.00 Very High Very High Very High
Morphine 190 100.00 Very High Very High Very High
Kinase C 184 100.00 Very High Very High Very High
long-term potentiation 171 100.00 Very High Very High Very High
addiction 102 100.00 Very High Very High Very High
tolerance 50 100.00 Very High Very High Very High
Antinociceptive 26 100.00 Very High Very High Very High
Immobilon 20 100.00 Very High Very High Very High
intrathecal 3 100.00 Very High Very High Very High
Delta-9-tetrahydrocannabinol 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 81 99.84 Very High Very High Very High
Adhesions 77 99.62 Very High Very High Very High
Aging 60 99.52 Very High Very High Very High
Alcohol Addiction 6 99.38 Very High Very High Very High
Anxiety Disorder 95 99.20 Very High Very High Very High
Virus Diseases 94 99.06 Very High Very High Very High
Nociception 82 99.00 Very High Very High Very High
Urological Neuroanatomy 20 98.92 Very High Very High Very High
Obesity 43 98.80 Very High Very High Very High
Hyperalgesia 69 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the effect of morphine antinociceptive tolerance on Protein Kinase A (PKA) activity in mouse brain (periaqueductal gray (PAG), thalamus, medulla) and lumbar spinal cord (LSC).
Spec (investigated) Regulation (effect) of PKA in thalamus associated with medulla, tolerance, thalamus, central grey, antinociceptive, spinal cord and morphine
1) Confidence 0.62 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.27 Pain Relevance 1.21
Studies suggest that acute and chronic opioids can regulate the cAMP-dependent protein kinase (PKA) signaling pathway and that changes in this pathway may be involved in opioid tolerance.
Regulation (regulate) of PKA associated with tolerance and opioid
2) Confidence 0.61 Published 2000 Journal Synapse Section Abstract Doc Link 11020235 Disease Relevance 0 Pain Relevance 0.67
Results demonstrated that chronic morphine treatment did not alter PKA activity or PKA kinetics in mouse brain.
Neg (not) Regulation (alter) of PKA in brain associated with morphine
3) Confidence 0.45 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.24 Pain Relevance 1.79
The involvement of cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) in the modulation of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes was examined.
Spec (examined) Regulation (involvement) of PKA associated with kinase c, diabetes mellitus, narcan, withdrawal and morphine
4) Confidence 0.45 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 0.45 Pain Relevance 1.02
The present study investigated the effect of different levels of Delta-9-tetrahydrocannabinol (Delta(9)-THC) antinociceptive tolerance on Protein Kinase A (PKA) activity in mouse brain and spinal cord.
Spec (investigated) Regulation (effect) of PKA in spinal cord associated with tolerance, delta-9-tetrahydrocannabinol, antinociceptive and spinal cord
5) Confidence 0.43 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15913565 Disease Relevance 0 Pain Relevance 0.34
We have investigated the effect of various protein kinase A (PKA) inhibitors on the phasic and tonic components of the response to potassium chloride (KCl) in the guinea pig ureter.
Spec (investigated) Regulation (effect) of PKA in ureter
6) Confidence 0.41 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8919654 Disease Relevance 0 Pain Relevance 0.13
The effect of down regulation of the AC/PKA pathway on aging and age-related disease in mammals has not been extensively studied [4].
Regulation (regulation) of PKA associated with aging and disease
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 0.68 Pain Relevance 0.04
Behavioral and anatomical studies by our group have suggested that the protein kinase A (PKA) signal transduction cascade contributes to long-term changes in nociceptive processing at the spinal cord level.
Regulation (contributes) of PKA in spinal cord associated with nociception and spinal cord
8) Confidence 0.35 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091547 Disease Relevance 0.18 Pain Relevance 0.24
This is likely due to the control of cAMP levels and PKA-activity in the vicinity of unoccupied, and thus, PDE4D-associated receptors in response to elevated cellular cAMP levels.
Spec (likely) Regulation (control) of PKA
9) Confidence 0.34 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.09
However, it is unclear which ion conductances are responsible for PKA-induced nociceptor hyperexcitability.
Regulation (responsible) of PKA in nociceptor associated with nociceptor and hyperexcitability
10) Confidence 0.34 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20962237 Disease Relevance 0.57 Pain Relevance 0.52
The regulation of kinases such as PKA and CaMKII has been studied in great detail, whereas much less attention has been given to the regulation of phosphatase activity.
Regulation (regulation) of PKA
11) Confidence 0.33 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.12
Although only PKA regulation has been directly proven, experiments show that glutamate inhibits phosphoThr75 [17] via a PP2A and calcium-dependent pathway.
Regulation (regulation) of PKA associated with glutamate
12) Confidence 0.33 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21
Results demonstrated that chronic morphine treatment did not alter PKA activity or PKA kinetics in mouse brain.
Neg (not) Regulation (alter) of PKA in brain associated with morphine
13) Confidence 0.27 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.24 Pain Relevance 1.78
These results suggest that spinal and supraspinal PKA activity are differentially altered during morphine tolerance in mice.
Regulation (altered) of PKA in spinal associated with tolerance and morphine
14) Confidence 0.27 Published 2005 Journal Pharmacol. Res. Section Abstract Doc Link 16026714 Disease Relevance 0.19 Pain Relevance 1.77
Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice.
Regulation (Role) of PKA associated with mu agonist, tolerance, opioid receptor and immobilon
15) Confidence 0.27 Published 2000 Journal Synapse Section Title Doc Link 11020235 Disease Relevance 0 Pain Relevance 1.05
CONCLUSIONS: The up-regulation of AC/cAMP-PKA signal system in some brain regions occurred in the state of morphine dependence and the effect was mediated via specific activation of opiate receptors.
Regulation (regulation) of PKA in brain
16) Confidence 0.27 Published 2000 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12903486 Disease Relevance 0 Pain Relevance 0
At that time, naloxone added to the incubation media caused an overshoot of cellular cAMP; (2) Long-term exposure to morphine could also induce the biphasic changes in cytosolic PKA activity.
Regulation (changes) of PKA
17) Confidence 0.26 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.08 Pain Relevance 0
1AR from PKA-mediated phosphorylation and desensitization (Rapacciuolo et al, 2003; Gardner et al, 2006) and may control PKA-mediated phosphorylation of other localized substrates.
Spec (may) Regulation (control) of PKA
18) Confidence 0.25 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.06
This study examined the effects of intrathecal treatment with the cAMP analogue 8-Bromo-cAMP and the PKA inhibitor H-89 dihydrochloride on nociceptive thresholds to mechanical stimulation in six adult sheep to define further the role of cAMP in spinal nociception.
Spec (examined) Regulation (effects) of PKA in spinal associated with nociception and intrathecal
19) Confidence 0.24 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11514065 Disease Relevance 0.59 Pain Relevance 0.27
Although abnormalities in PKA activation have been associated with differences in response to noradrenergic antidepressants (Gurguis et al 1999), a systematic study of polymorphisms affecting PKA has not yet been performed.
Regulation (affecting) of PKA associated with antidepressant and congenital anomalies
20) Confidence 0.22 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.15 Pain Relevance 0.32

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