INT66383

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Context Info
Confidence 0.80
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 143
Total Number 144
Disease Relevance 30.85
Pain Relevance 43.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
neurons 5
HT-29 3
spinal 3
platelets 2
PGE2 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1891 100.00 Very High Very High Very High
Kinase C 460 100.00 Very High Very High Very High
opioid receptor 124 100.00 Very High Very High Very High
Stimulus evoked pain 8 100.00 Very High Very High Very High
Inflammation 589 99.92 Very High Very High Very High
agonist 1071 99.78 Very High Very High Very High
Gabapentin 14 99.78 Very High Very High Very High
IPN 156 99.66 Very High Very High Very High
Spinal sensitization 19 99.50 Very High Very High Very High
amygdala 85 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 182 100.00 Very High Very High Very High
Hypersensitivity 51 100.00 Very High Very High Very High
INFLAMMATION 727 99.92 Very High Very High Very High
Cancer 169 99.62 Very High Very High Very High
Stress 116 99.54 Very High Very High Very High
Nociception 447 99.46 Very High Very High Very High
Targeted Disruption 525 99.22 Very High Very High Very High
Nervous System Injury 42 98.72 Very High Very High Very High
Congenital Anomalies 38 98.64 Very High Very High Very High
Apoptosis 271 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opposite effects of isoproterenol on the kainate- and veratridine-evoked releases may reflect prevention of the cyclic AMP-protein kinase A (PKA) phosphorylation cascade in striatal glutamatergic signal transduction.
Phosphorylation (phosphorylation) of PKA
1) Confidence 0.80 Published 2003 Journal Neurochem. Int. Section Abstract Doc Link 12742088 Disease Relevance 0 Pain Relevance 0.39
Here we show that transplantation of pre-differentiated ES cells activate both brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) signaling pathways in the host tissue, leading to activation of cAMP/PKA, phosporylation of cofilin and synapsin I, and promoting regenerative growth and neuronal survival.
Phosphorylation (phosporylation) of PKA in neuronal
2) Confidence 0.79 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19138107 Disease Relevance 0.41 Pain Relevance 0.15
PKA inhibitor could significantly inhibit this change; (4) Concomitant administration of naloxone could block the changes in PKA activity and c-Fos phosphorylation described above.
Phosphorylation (phosphorylation) of PKA
3) Confidence 0.79 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.06 Pain Relevance 0
The present findings are consistent with the view that phosphorylation by PKA increases the availability of L-type Ca channels in the ureter smooth muscle.
Phosphorylation (phosphorylation) of PKA in ureter
4) Confidence 0.74 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8919654 Disease Relevance 0 Pain Relevance 0.15
As the protein kinase A (PKA) inhibitor H-89 but not the protein kinase C inhibitor chelerythrine abolished the inhibitory action of gabapentin on IPSCs, PKA-mediated phosphorylation seems to be important for supraspinal gabapentin responsiveness in neuropathic conditions.
Phosphorylation (phosphorylation) of PKA-mediated associated with neuropathic pain, gabapentin and kinase c inhibitor
5) Confidence 0.63 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182059 Disease Relevance 0.34 Pain Relevance 1.48
Furthermore, that PKA affecting AC phosphorylated state and leading to the increase of AC activity suggest that the increase of PKA activities during chronic morphine treatment could lead to the positive feedback regulation in AC/cAMP system and further potentiate the AC/cAMP system, and these may be one of important mechanisms by which chronic opiate induce dependence in target neurons.


Phosphorylation (phosphorylated) of PKA in neurons
6) Confidence 0.62 Published 2000 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12903486 Disease Relevance 0 Pain Relevance 0
phosphorylation by protein kinase A (PKA) was shown to enhance its activity [31].
Phosphorylation (phosphorylation) of PKA
7) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.12 Pain Relevance 0
Downstream of binding to its G protein-coupled receptor (GPCR), PGE2 sensitizes nociceptive neurons to thermal stimuli via PKA-dependent phosphorylation of the heat- and capsaicin-gated Transient Receptor Potential (TRP) ion channel TRPV1 [1].
Phosphorylation (phosphorylation) of PKA in neurons associated with nociception and qutenza
8) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 0.55 Pain Relevance 0.31
GlyRs are not modulated by PKA phosphorylation.
Phosphorylation (phosphorylation) of PKA
9) Confidence 0.61 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2944627 Disease Relevance 0.46 Pain Relevance 0.07
The increase in P(o) of these channels was also seen in an inside-out configuration and in the presence of PKA, ATP, and cAMP, but not with cAMP alone; phosphorylation did not influence single-channel conductance.
Phosphorylation (phosphorylation) of PKA
10) Confidence 0.53 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820801 Disease Relevance 0 Pain Relevance 0.09
Back-phosphorylation experiments showed a drop in cAMP-dependent protein kinase A (PKA)-induced receptor phosphorylation shortly after acute morphine administration, followed by a naloxone-reversible increase in phosphorylation of the receptor that correlated with the onset of antinociception.
Phosphorylation (phosphorylation) of PKA associated with antinociception, narcan and morphine
11) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582426 Disease Relevance 0 Pain Relevance 1.25
Analyses of brain Na+ channels have shown that the cytoplasmic loop between domains DI and DII of Na+ channels possesses several shared PKA and PKC phosphorylation sites [19–20].
Phosphorylation (phosphorylation) of PKA in brain
12) Confidence 0.47 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0.05 Pain Relevance 0.12
LTP-inducing high-frequency stimulation has been reported to cause sustained DARPP-32 phosphorylation by PKA in a manner dependent on CaMKII in hippocampal slices (Atkins et al, 2005).
Phosphorylation (phosphorylation) of PKA associated with long-term potentiation
13) Confidence 0.46 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.12
Lack of PDE4D causes PKA hyperphosphorylation of RyR2 and calstabin depletion from the channel, resulting in a ‘leaky' RyR2 channel phenotype that, in turn, may contribute to cardiac arrhythmias.
Phosphorylation (hyperphosphorylation) of PKA
14) Confidence 0.46 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.22 Pain Relevance 0
1AR from PKA-mediated phosphorylation and desensitization (Rapacciuolo et al, 2003; Gardner et al, 2006) and may control PKA-mediated phosphorylation of other localized substrates.
Phosphorylation (phosphorylation) of PKA
15) Confidence 0.46 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.07
A PKA-site-specific antibody from Cell Signaling (Danvers, MA) was used to measure PKA phosphorylation of the ?
Phosphorylation (phosphorylation) of PKA
16) Confidence 0.46 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.18 Pain Relevance 0
Indeed, a reduction of PDE1 activity increased cAMP, facilitating the PKA activity and DARPP-32 phosphorylation.
Phosphorylation (phosphorylation) of PKA
17) Confidence 0.45 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
PDE1 causes weaker but longer-lasting DARPP-32 dephosphorylation indirectly through alteration of the PKA activity (see Supplementary Figure 6).
Phosphorylation (dephosphorylation) of PKA
18) Confidence 0.45 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
We have recently reported that neurotensin stimulates the phosphorylation of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa) at Thr34 (PKA-site) by activating dopamine D1-type receptors in neostriatal neurons.
Phosphorylation (phosphorylation) of PKA in neurons associated with dopamine
19) Confidence 0.45 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.21
Therefore, the model has three active forms of PP2A: the basal form with a low kcat, a phosphorylated form (PP2Ap, phosphorylated by PKA) with a higher kcat [25], and a form that is activated directly by calcium, PP2Ac.
Phosphorylation (phosphorylated) of PKA
20) Confidence 0.44 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.08

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