INT66388

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.45
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
substantia nigra pars reticulata 4
anterior 2
striatum 2
amygdala 2
CNS 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
GABAergic 149 99.62 Very High Very High Very High
amygdala 10 99.36 Very High Very High Very High
gABA 62 99.30 Very High Very High Very High
Dopamine 33 99.22 Very High Very High Very High
Spinal cord 8 98.36 Very High Very High Very High
Analgesic 5 94.80 High High
substance P 9 93.32 High High
nMDA receptor 3 93.00 High High
Substantia nigra 11 91.52 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 177 100.00 Very High Very High Very High
Disease 42 99.84 Very High Very High Very High
Dyskinesias 43 99.56 Very High Very High Very High
Stress 10 97.72 Very High Very High Very High
Nociception 7 96.84 Very High Very High Very High
Neuropathic Pain 8 89.72 High High
Frailty 1 87.44 High High
Cold Sores 2 83.84 Quite High
Herpes Simplex Virus 1 83.64 Quite High
Sleep Disorders 36 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CB(1) mRNA was localized to putative GABAergic interneurons that express high levels of GAD67 mRNA.
Positive_regulation (levels) of Transcription (express) of GAD67 in interneurons associated with gabaergic
1) Confidence 0.67 Published 2000 Journal Synapse Section Abstract Doc Link 10842353 Disease Relevance 0 Pain Relevance 0.38
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Positive_regulation (increases) of Transcription (levels) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
2) Confidence 0.50 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.08 Pain Relevance 0.36
Thalamic lesions prevented most of the dopamine denervation-induced changes (i.e. the increases in mRNA levels of enkephalin and GAD67 in the striatum, of GAD67 in the globus pallidus and entopeduncular nucleus, and of cytochrome oxidase subunit-I in the subthalamic nucleus), but did not affect the downregulation of striatal substance P and upregulation of GAD67 in the substantia nigra pars reticulata.
Positive_regulation (increases) of Transcription (levels) of GAD67 in substantia nigra pars reticulata associated with dopamine, substantia nigra, enkephalin and substance p
3) Confidence 0.50 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.08 Pain Relevance 0.36
The increased GABA release and the apparent adaptive increase in GAD67 mRNA levels by the strongest stimulation may be due to an endogenous inhibitory neuroprotective response to an excitotoxic influence.
Positive_regulation (increase) of Transcription (levels) of GAD67 associated with gaba
4) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332739 Disease Relevance 0 Pain Relevance 0.47
As reported previously, the unilateral dopaminergic lesion resulted in marked increases in GAD67 mRNA levels in the ipsilateral striatum.
Positive_regulation (increases) of Transcription (levels) of GAD67 in striatum
5) Confidence 0.46 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.55
Long-term increase in GAD67 mRNA expression in the central amygdala of rats sensitized by drugs and stress.
Positive_regulation (increase) of Transcription (expression) of GAD67 in amygdala associated with stress and amygdala
6) Confidence 0.46 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18312583 Disease Relevance 0.37 Pain Relevance 0.49
Thus, supranigral infusions of BDNF or NT-4/5 increase tachykinin mRNA and protein levels within striatonigral neurons and increase the size and GAD67 mRNA expression levels of nigral GABAergic neurons.
Positive_regulation (increase) of Transcription (expression) of GAD67 in GABAergic neurons associated with gabaergic
7) Confidence 0.45 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921261 Disease Relevance 0.08 Pain Relevance 0.62
Striatal glutamic acid decarboxylase mRNA levels in PD and LID
Positive_regulation (Striatal) of Transcription (levels) of glutamic acid decarboxylase associated with disease and dyskinesias
8) Confidence 0.42 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.37 Pain Relevance 0.04
Fos immunohistochemistry combined with GAD67 mRNA in situ hybridization
Positive_regulation (hybridization) of Transcription (combined) of GAD67
9) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.23 Pain Relevance 0.12
Controls in the absence of primary antibodies (anti-Fos and anti-DIG) and with the sense probe (GAD67 cDNA linearised with HindIII restriction enzyme and transcribed using T7 RNA polymerase) were run to ensure the absence of nonspecific labeling.
Positive_regulation (using) of Transcription (transcribed) of GAD67
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.11 Pain Relevance 0
Both fluphenazine and SCH-23390 significantly enhanced preproenkephalin and glutamic acid decarboxylase (GAD) mRNA expression in the anterior striatum.
Positive_regulation (enhanced) of Transcription (expression) of glutamic acid decarboxylase in anterior associated with generalized anxiety disorder
11) Confidence 0.32 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9387879 Disease Relevance 0.20 Pain Relevance 0.10
In these experiments increased expression of GAD67 mRNA was demonstrated in DRG and an increase in extracellular GABA was found in the spinal cord [8], suggesting that most of the analgesic effect resulted from GABA expression in sensory neurons followed by transport and release from terminals in the CNS.
Positive_regulation (increased) of Transcription (expression) of GAD67 in CNS associated with gaba, analgesic, central nervous system and spinal cord
12) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.84 Pain Relevance 1.10
Fos immunohistochemistry combined with GAD67 mRNA in situ hybridization
Positive_regulation (hybridization) of Transcription (combined) of GAD67
13) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.05 Pain Relevance 0.07
Controls in the absence of primary antibodies (anti-Fos and anti-DIG) and with the sense probe (GAD67 cDNA linearised using HindIII and transcribed using T7 RNA polymerase) were run to ensure the absence of nonspecific labeling.
Positive_regulation (using) of Transcription (transcribed) of GAD67
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.06 Pain Relevance 0

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