INT66391

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Context Info
Confidence 0.04
First Reported 1995
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Ddx5) nucleolus (Ddx5) nucleus (Ddx5)
enzyme binding (Ddx5)
Anatomy Link Frequency
striatum 3
Ddx5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 19 100.00 Very High Very High Very High
substance P 15 100.00 Very High Very High Very High
cerebral cortex 2 99.70 Very High Very High Very High
nMDA receptor antagonist 2 98.16 Very High Very High Very High
Lamotrigine 4 97.64 Very High Very High Very High
Glutamate 4 96.72 Very High Very High Very High
Substantia nigra 1 94.08 High High
Dopamine 4 75.00 Quite High
nMDA receptor 2 65.68 Quite High
Deafferentation 1 51.04 Quite High
Disease Link Frequency Relevance Heat
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral ablation of the cerebral cortex resulted in a decrease of substance P mRNA levels particularly in the rostral dorsolateral and dorsomedial striatum ipsilateral to the lesion.
Negative_regulation (decrease) of P mRNA in striatum associated with cerebral cortex and substance p
1) Confidence 0.04 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 9620062 Disease Relevance 0 Pain Relevance 0.62
Continuous, intrastriatal infusion of the competitive NMDA receptor antagonist, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, (CPP, 0.12 and 1.2microg/day) decreased both enkephalin mRNA and substance P mRNA in dose-dependent manner evenly throughout the striatum adjacent to the infusion site.
Negative_regulation (decreased) of P mRNA in striatum associated with nmda receptor antagonist, enkephalin and substance p
2) Confidence 0.03 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 9620062 Disease Relevance 0 Pain Relevance 0.93
In animals with bilateral lesion, substance P mRNA levels were decreased in the striatum, and this was matched by parallel reductions in substance P immunoreactivity in the striatum and in the striatonigral terminals at substantia nigra level in both hemispheres.
Negative_regulation (decreased) of P mRNA in striatum associated with substantia nigra and substance p
3) Confidence 0.02 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921265 Disease Relevance 0 Pain Relevance 0.62

General Comments

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