INT66392

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.72
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
neurons 1
brain 1
Pdc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 99.50 Very High Very High Very High
Glutamate 48 99.40 Very High Very High Very High
Thalamus 55 84.60 Quite High
Anterior cingulate cortex 33 84.32 Quite High
primary somatosensory cortex 28 83.92 Quite High
excitatory amino acid 4 80.32 Quite High
Morphine 87 78.76 Quite High
nMDA receptor 5 75.00 Quite High
nMDA receptor antagonist 4 74.28 Quite High
antagonist 6 72.20 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 36 100.00 Very High Very High Very High
Pain 64 50.00 Quite Low
Toxicity 8 45.56 Quite Low
Nociception 11 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDC also evoked release of endogenous glutamate.
Localization (release) of PDC associated with glutamate
1) Confidence 0.65 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.66 Pain Relevance 0.59
Tetrodotoxin had no effect on either PDC neurotoxicity or on PDC-evoked [3H]-D-aspartate release.
Localization (release) of PDC associated with tetrodotoxin and drug induced neurotoxicity
2) Confidence 0.61 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.69 Pain Relevance 0.65
Tetrodotoxin had no effect on either PDC neurotoxicity or on PDC-evoked [3H]-D-aspartate release.
Localization (release) of PDC associated with tetrodotoxin and drug induced neurotoxicity
3) Confidence 0.61 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.69 Pain Relevance 0.64
PDC-evoked release of [3H]-D-aspartate was demonstrable in astrocyte cultures with no neurons present.
Localization (release) of PDC in neurons
4) Confidence 0.61 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.68 Pain Relevance 0.61
Then the first principal component (PC1) of a given brain area was exported into MatLab to calculate PDC (in 1-50 Hz range).
Localization (exported) of PDC in brain
5) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770513 Disease Relevance 0 Pain Relevance 0.32

General Comments

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