INT66394

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.27
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
neuronal 1
synapses 1
cortex 1
Pdc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 42 100.00 Very High Very High Very High
wide dynamic range 12 100.00 Very High Very High Very High
tetrodotoxin 1 99.84 Very High Very High Very High
antagonist 11 99.68 Very High Very High Very High
Abeta 8 99.64 Very High Very High Very High
Face pain 4 98.80 Very High Very High Very High
hyperexcitability 2 98.68 Very High Very High Very High
Cannabinoid receptor 8 97.80 Very High Very High Very High
agonist 11 96.96 Very High Very High Very High
Hippocampus 4 93.48 High High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 9 99.96 Very High Very High Very High
Facial Pain 4 98.80 Very High Very High Very High
Nociception 4 75.00 Quite High
Toxicity 3 46.24 Quite Low
Epilepsy 16 5.00 Very Low Very Low Very Low
Convulsion 5 5.00 Very Low Very Low Very Low
Partial Seizures 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SR141716A, a CB1 receptor antagonist, prevented the effects of WIN on WDR PDC and LTM Abeta evoked activity.
Regulation (effects) of PDC associated with antagonist, wide dynamic range and abeta
1) Confidence 0.32 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.24 Pain Relevance 1.28
In contrast to sIPSCs, the amplitude and decay time of sEPSCs was not significantly affected by tiagabine, so it seems unlikely that the drug (at the concentration tested) has an effect on glutamate uptake (cf PDC) at these synapses.
Regulation (effect) of PDC in synapses associated with glutamate
2) Confidence 0.25 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.33
Tetrodotoxin had no effect on either PDC neurotoxicity or on PDC-evoked [3H]-D-aspartate release.
Neg (no) Regulation (effect) of PDC associated with tetrodotoxin and drug induced neurotoxicity
3) Confidence 0.23 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.69 Pain Relevance 0.64
Furthermore, the particular sensitivity of PDC activity, a measure of neuronal hyperexcitability, to cannabinoid receptor agonists may be relevant to the treatment of persistent craniofacial pain.
Regulation (sensitivity) of PDC in neuronal associated with cannabinoid receptor, face pain, agonist and hyperexcitability
4) Confidence 0.22 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.34 Pain Relevance 1.19
proteins, and Annexin IV were down regulated in PDC after PGF2?
Regulation (regulated) of PDC
5) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.11
In this study, a variation of partial directed coherence, the generalized partial directed coherence (gPDC), along with a newly proposed critical value for gPDC, were applied on recorded local field potentials (LFPs) and single-unit activity, in order to assess information flow between medial prefrontal cortex (mPFC) and hippocampus and within the hippocampus of the rat brain, under isoflurane anesthesia and kainic acid-induced enhanced neuronal activity.
Regulation (value) of gPDC in cortex associated with anesthesia, isoflurane and hippocampus
6) Confidence 0.07 Published 2010 Journal Biol Cybern Section Abstract Doc Link 20204395 Disease Relevance 0 Pain Relevance 0.44

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