INT664

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Context Info
Confidence 0.46
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.75
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgg) extracellular space (Fgg) extracellular region (Fgg)
protein binding, bridging (Fgg)
Anatomy Link Frequency
plasma 3
joints 1
blood 1
platelet 1
Fgg (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 72 99.88 Very High Very High Very High
Inflammation 230 99.48 Very High Very High Very High
Paracetamol 10 99.40 Very High Very High Very High
cytokine 45 97.76 Very High Very High Very High
Angina 5 95.72 Very High Very High Very High
Osteoarthritis 10 94.76 High High
anesthesia 4 90.68 High High
Pain 3 77.52 Quite High
abdominal pain 1 70.20 Quite High
tolerance 1 66.80 Quite High
Disease Link Frequency Relevance Heat
Shock 4 100.00 Very High Very High Very High
Arrhythmia Under Development 2 99.92 Very High Very High Very High
Rheumatoid Arthritis 73 99.88 Very High Very High Very High
Chronic Renal Failure 62 99.70 Very High Very High Very High
INFLAMMATION 237 99.48 Very High Very High Very High
Infection 26 99.16 Very High Very High Very High
Heart Rate Under Development 24 98.84 Very High Very High Very High
Cardiovascular Disease 90 96.48 Very High Very High Very High
Cv General 3 Under Development 32 95.72 Very High Very High Very High
Osteoarthritis 10 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased red-cell flexibility tends to counteract the effect of increased plasma-fibrinogen concentration, which tends to increase blood-viscosity.
Positive_regulation (increased) of plasma-fibrinogen in blood
1) Confidence 0.46 Published 1977 Journal Lancet Section Abstract Doc Link 72287 Disease Relevance 0.34 Pain Relevance 0.34
Acetaminophen treatment also significantly increased plasminogen activator inhibitor-1 (PAI-1) activity and plasma fibrinogen level, and decreased antithrombin III (AT-III) and protein C activities (P < 0.05).
Positive_regulation (increased) of fibrinogen in plasma associated with paracetamol
2) Confidence 0.08 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.21 Pain Relevance 0.69
We measured CRP and fibrinogen in plasma by immunonephelometry (Prospec, Dade Behring Milton Keynes, UK) using the manufacturer's reagents and standards.
Positive_regulation (measured) of fibrinogen in plasma
3) Confidence 0.07 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.92 Pain Relevance 0.06
The fibrinogen level was significantly elevated after LPS challenge (p < 0.01 vs. vehicle).
Positive_regulation (elevated) of fibrinogen
4) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0 Pain Relevance 0
We measured prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, activated protein C (APC), and activity for von Willebrand factor (vWF) (n = 14–16 in each group) using a commercial kit (Diagnostica Stago, Roche, Tokyo, Japan) and an STA Compact analyzer (Diagnostica Stago, Roche) as previously described (Inoue et al. 2004).


Positive_regulation (activated) of fibrinogen
5) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.30 Pain Relevance 0.12
As a result, AELR and P(2) significantly shortened BT, CT and thrombin time (TT), and increased fibrinogen (FIB), but P(1) and P(3) showed no hemostatic effect during the experiment.
Positive_regulation (increased) of fibrinogen
6) Confidence 0.07 Published 2009 Journal Phytother Res Section Abstract Doc Link 19173219 Disease Relevance 0.35 Pain Relevance 0.08
They had higher levels of IL-6, CRP, fibrinogen, white cell count, and glucose.


Positive_regulation (levels) of fibrinogen
7) Confidence 0.06 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 1.02 Pain Relevance 0
Patients with RA have increased serum levels of fibrinogen, von Willebrand factor and tissue plasminogen activator antigen compared with controls and these prothrombotic markers have been shown to predict cardiovascular events in patients with RA (McEntegart et al 2001; Sattar et al 2003).


Positive_regulation (increased) of fibrinogen associated with rheumatoid arthritis
8) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.49 Pain Relevance 0.33
For example, a wide range of endogenous TLR activators, including heat shock proteins, HMGB1, host DNA, fibrinogen, FNEDA, and tenascin-C, are observed in synovia of RA patients but not in synovia from normal joints or non-inflamed synovia from osteoarthritis (OA) patients [106–112].
Positive_regulation (activators) of fibrinogen in joints associated with shock, rheumatoid arthritis and osteoarthritis
9) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.18 Pain Relevance 0.24
Dose-dependent increases in C-reactive protein (CRP) and fibrinogen levels were observed on day 8 (P < .0001 for both).
Positive_regulation (increases) of fibrinogen
10) Confidence 0.01 Published 1995 Journal Blood Section Abstract Doc Link 7537110 Disease Relevance 0.40 Pain Relevance 0.03
Even in the absence of overt infection or inflammation, many ESRD patients show increased levels of acute-phase proteins, such as C-reactive protein (CRP), ferritin, fibrinogen, and/or interleukin-6 (IL-6), associated with low serum albumin levels [22].
Positive_regulation (increased) of fibrinogen associated with chronic renal failure, inflammation and infection
11) Confidence 0.01 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 1.23 Pain Relevance 0.21
Studies on the biological mechanism found that increased NO2 is associated with increased plasma fibrinogen, ventricular arrhythmia and ventricular tachycardia [32-34].
Positive_regulation (increased) of fibrinogen in plasma associated with heart rate under development and arrhythmia under development
12) Confidence 0.01 Published 2010 Journal Environ Health Section Body Doc Link PMC2972268 Disease Relevance 0.42 Pain Relevance 0
Previous animal studies had shown biological activity at a human equivalent dose of 10 mg/day; furthermore a parallel study in healthy volunteers showed doses of 25 mg/day and 100 mg/day had similar effects on fibrinogen, biochemical bone markers, low density lipoprotein (LDL), cholesterol, and gonadotrophin concentrations (Münster et al. 2001).
Positive_regulation (had) of fibrinogen
13) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.48 Pain Relevance 0
These alterations, in turn, could explain the observed decrease in platelet count and fibrinogen level and subsequent increase in thrombin-antithrombin III complex, prothrombin fragment F1+2, and D-dimer concentrations [11].
Positive_regulation (increase) of fibrinogen in platelet
14) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.41 Pain Relevance 0

General Comments

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