INT6640

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Avpr2) signal transducer activity (Avpr2)
Anatomy Link Frequency
plasma 1
inner medulla 1
Avpr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
medulla 1 99.26 Very High Very High Very High
Endogenous opioid 1 98.68 Very High Very High Very High
Enkephalin 1 97.16 Very High Very High Very High
agonist 1 87.28 High High
bradykinin 2 76.32 Quite High
antagonist 8 75.00 Quite High
Opioid 1 75.00 Quite High
Potency 1 74.40 Quite High
Dismenorea 1 55.36 Quite High
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Hypothermia 4 99.74 Very High Very High Very High
Chronic Renal Failure 124 99.40 Very High Very High Very High
Diuresis 4 99.14 Very High Very High Very High
Uremia 4 80.56 Quite High
Congenital Anomalies 1 72.84 Quite High
Dysmenorrhea 1 55.36 Quite High
Hypertrophy 11 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH).
Spec (whether) Negative_regulation (depression) of antidiuretic hormone associated with diuresis, hypothermia and depression
1) Confidence 0.37 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597114 Disease Relevance 0.37 Pain Relevance 0.09
In general, this class exhibited good selectivity for binding to the oxytocin receptor versus the arginine vasopressin V1a and V2 receptor subtypes, although increased V2 receptor affinity was observed in one case (32, cyclo[L-prolyl-D-2-naphthylalanyl-L-isoleucyl-D-pipecolyl-L- lysyl-D-(N- methyl)phenylalanyl]).
Negative_regulation (exhibited) of V2 receptor
2) Confidence 0.09 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1331448 Disease Relevance 0.06 Pain Relevance 0.23
To study the physiological roles of endogenous opioid peptides in drinking and feeding behaviors, the effects of water deprivation and fasting on plasma immunoreactive (IR) beta-endorphin (beta-end), IR-Antidiuretic hormone (ADH) and IR-Prolactin (Prl), pituitary IR-beta-end and IR-methionine-enkephalin (IR-Met-enk) and IR-ADH, and hypothalamic IR-beta-end and IR-Met-enk were observed in rats.
Negative_regulation (deprivation) of IR-Antidiuretic hormone in plasma associated with endogenous opioid and enkephalin
3) Confidence 0.08 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 2944140 Disease Relevance 0 Pain Relevance 0.27
As an extension of these observations, Teitelbaum and McGuinness (24) observed that RT-PCR of total RNA from the inner medulla of CRF rat kidneys revealed virtual absence of V2 receptor mRNA.
Negative_regulation (absence) of V2 receptor mRNA in inner medulla associated with medulla and chronic renal failure
4) Confidence 0.05 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

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