INT66416

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2010
Negated 10
Speculated 20
Reported most in Abstract
Documents 66
Total Number 86
Disease Relevance 17.32
Pain Relevance 68.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
nucleus 5
spinal cord 4
neurons 4
brain 3
MVN 3
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 679 100.00 Very High Very High Very High
Opioid 82 100.00 Very High Very High Very High
antagonist 71 100.00 Very High Very High Very High
electroacupuncture 66 100.00 Very High Very High Very High
Morphine 66 100.00 Very High Very High Very High
narcan 63 100.00 Very High Very High Very High
Pain 59 100.00 Very High Very High Very High
Inflammation 34 100.00 Very High Very High Very High
intrathecal 24 100.00 Very High Very High Very High
nociceptor 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 50 99.98 Very High Very High Very High
Pain 33 99.84 Very High Very High Very High
Fibromyalgia 6 99.68 Very High Very High Very High
INFLAMMATION 23 99.66 Very High Very High Very High
Urological Neuroanatomy 15 99.52 Very High Very High Very High
Lordosis 4 99.00 Very High Very High Very High
Hyperalgesia 35 98.96 Very High Very High Very High
Substance Withdrawal Syndrome 3 98.56 Very High Very High Very High
Neuropathic Pain 24 98.52 Very High Very High Very High
Bordatella Infection 3 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of intrathecal orphanin FQ, the endogenous ligand for the orphan opioid-like receptor, on the hamstring nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats after carrageenan-induced inflammation or unilateral sciatic nerve transection.
Spec (examined) Regulation (effects) of orphanin FQ in hamstring associated with nociception, inflammation, orphanin, sciatic nerve, opioid and intrathecal
1) Confidence 0.61 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10323275 Disease Relevance 0.33 Pain Relevance 0.64
In the present study, we investigated the influence of intrathecal (i.t.) administration of morphine and endomorphin-1 on the level of pronociceptin/orphanin FQ and opioid receptor-like 1 (ORL1) receptor mRNAs in the lumbar part of the spinal cord in the rat model of neuropathic pain.
Spec (investigated) Regulation (influence) of orphanin FQ in spinal cord associated with orphanin, neuropathic pain, opioid receptor, spinal cord, morphine and intrathecal
2) Confidence 0.60 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159147 Disease Relevance 0.35 Pain Relevance 0.92
Naloxone (10 microM), a non-selective opioid receptor antagonist, did not affect the inhibitory effect of nociceptin whereas it abolished that of DAGO.
Neg (not) Regulation (affect) of nociceptin associated with orphanin, antagonist, narcan and opioid receptor
3) Confidence 0.59 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879729 Disease Relevance 0 Pain Relevance 0.95
Such alternative splicing to create a truncated ORL1 receptor might be an endogenous mechanism to negatively regulate nociceptin/ORL1 functions.
Regulation (regulate) of nociceptin associated with orphanin
4) Confidence 0.58 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.30
Effects of electroacupuncture on orphanin FQ immunoreactivity and preproorphanin FQ mRNA in nucleus of raphe magnus in the neuropathic pain rats.
Regulation (Effects) of preproorphanin FQ in nucleus associated with pain, raphe magnus, orphanin, neuropathic pain and electroacupuncture
5) Confidence 0.58 Published 2004 Journal Brain Res. Bull. Section Title Doc Link 15249116 Disease Relevance 0.49 Pain Relevance 1.56
Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.
Regulation (regulation) of orphanin FQ associated with orphanin and opioid receptor
6) Confidence 0.55 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 16538678 Disease Relevance 0.08 Pain Relevance 0.42
For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates lordosis in female rats through estrogen and progesterone regulation of nociceptin activity.
Regulation (regulation) of nociceptin in VMH associated with orphanin and lordosis
7) Confidence 0.55 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16538678 Disease Relevance 0.10 Pain Relevance 0.38
Strong positive prepulses counteracted the inhibition of the peak current by 64% and no effect of nociceptin was observed when the cells were pre-incubated with Pertussis toxin.
Neg (no) Regulation (effect) of nociceptin associated with bordatella infection and orphanin
8) Confidence 0.53 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11108996 Disease Relevance 0.35 Pain Relevance 0.55
This paradigm was subsequently used to investigate the effects of nociceptin, an opioid-like peptide involved in central and peripheral control of nociception.
Spec (investigate) Regulation (effects) of nociceptin associated with nociception, orphanin and opioid
9) Confidence 0.51 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17640294 Disease Relevance 0.10 Pain Relevance 0.52
The experiments were carried out to investigate the changes of OFQ-like immunoreactivity and prepro-orphanin FQ (ppOFQ) mRNA in some certain nuclei of the rat brain.
Spec (investigate) Regulation (changes) of orphanin FQ in brain associated with orphanin
10) Confidence 0.51 Published 2001 Journal Acupunct Electrother Res Section Abstract Doc Link 11394493 Disease Relevance 0.24 Pain Relevance 0.55
While the influence of orphanin FQ (OFQ) on the regulation of food intake has been substantiated, little is known about feeding-related brain regions that mediate OFQ-induced feeding.
Regulation (regulation) of orphanin FQ in brain associated with orphanin
11) Confidence 0.46 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650146 Disease Relevance 0 Pain Relevance 0.15
Therefore, the nociceptin-induced reduction of DA release stimulated by morphine in the nucleus accumbens, and the results obtained with nociceptin in the conditioned place preference procedure suggest a role for nociceptin in the modulation of the behavioral and neurochemical effects of abuse drugs.
Regulation (modulation) of nociceptin in nucleus accumbens associated with nucleus accumbens, dopamine, orphanin and morphine
12) Confidence 0.45 Published 2000 Journal Peptides Section Abstract Doc Link 10998547 Disease Relevance 0 Pain Relevance 1.34
For behavioral studies, NMDA-induced scratching behavior was used to assess the effects of orphanin FQ.
Regulation (effects) of orphanin FQ associated with orphanin
13) Confidence 0.45 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672614 Disease Relevance 0.49 Pain Relevance 0.42
Since numerous studies have implicated activation of the mesolimbic dopamine pathway to be central to the rewarding actions of opiates such as morphine and heroin, as well as several other abused drugs, and also to mediate the hyperlocomotory action of such drugs, we sought to determine the effect of orphanin FQ on this pathway.
Spec (determine) Regulation (effect) of orphanin FQ associated with dopamine, orphanin, opiate and morphine
14) Confidence 0.45 Published 1996 Journal Neuroscience Section Abstract Doc Link 8923516 Disease Relevance 0.07 Pain Relevance 1.26
Regional hemodynamic effects of nociceptin/orphanin FQ in the anesthetized rat.
Regulation (effects) of nociceptin associated with orphanin
15) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12208319 Disease Relevance 0 Pain Relevance 0.43
The effects of nociceptin (orphanin FQ) on medial vestibular nucleus (MVN) neurons in vitro, and on vestibulo-ocular reflex (VOR) function in vivo, were investigated in order to determine the role of 'opioid-like orphan' (ORL1) receptors in modulating vestibular reflex function in the rat.
Spec (investigated) Regulation (effects) of nociceptin in MVN associated with orphanin and opioid
16) Confidence 0.45 Published 1999 Journal Brain Res. Section Abstract Doc Link 10320726 Disease Relevance 0 Pain Relevance 0.44
Effects of intrathecal orphanin FQ on a flexor reflex in the rat after inflammation or peripheral nerve section.
Regulation (Effects) of orphanin FQ in peripheral nerve associated with inflammation, orphanin and intrathecal
17) Confidence 0.45 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10323275 Disease Relevance 0.52 Pain Relevance 1.00
The effect of nociceptin, an endogenous ligand for a unique member of the cloned opioid receptor family ORL1-receptor, on tonic activity of neurons in the preoptic area/anterior hypothalamus (PO/AH) has been examined in rat brain slices using extracellular recordings.
Spec (examined) Regulation (effect) of nociceptin in neurons associated with orphanin and opioid receptor
18) Confidence 0.44 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10553944 Disease Relevance 0 Pain Relevance 0.36
We have studied the effects of nociceptin/orphanin FQ on the histaminergic neurons in the tuberomammillary (TM) nucleus and compared them with the actions of opioid agonists.
Regulation (effects) of orphanin FQ in nucleus associated with mu agonist and orphanin
19) Confidence 0.44 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10974333 Disease Relevance 0 Pain Relevance 0.45
The effects of nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist JTC-801 on allodynia and hyperalgesia were examined in rats in order to explore the involvement of N/OFQ system in these pathological pain states.
Regulation (effects) of orphanin FQ associated with pain, hyperalgesia, allodynia, antagonist and orphanin
20) Confidence 0.44 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15763246 Disease Relevance 0.67 Pain Relevance 0.84

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