INT66417

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Context Info
Confidence 0.80
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 34
Total Number 34
Disease Relevance 1.61
Pain Relevance 24.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
brain 5
nucleus accumbens 4
spinal cord 3
central nervous system 2
blood 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 241 100.00 Very High Very High Very High
Dopamine 63 100.00 Very High Very High Very High
Morphine 51 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
narcan 34 100.00 Very High Very High Very High
Central nervous system 21 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
opiate 10 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
Nucleus accumbens 34 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 100.00 Very High Very High Very High
Bradycardia 1 100.00 Very High Very High Very High
Nociception 4 97.92 Very High Very High Very High
Heart Rate Under Development 1 97.36 Very High Very High Very High
Urological Neuroanatomy 8 94.00 High High
Hyperalgesia 2 90.72 High High
Ocular Toxicity (including Many Sub-types) 1 90.72 High High
Hypotension 2 80.24 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system.
Localization (release) of Nociceptin in central nervous system associated with neurotransmitter, orphanin and central nervous system
1) Confidence 0.80 Published 2000 Journal Peptides Section Title Doc Link 10998536 Disease Relevance 0 Pain Relevance 1.01
These findings demonstrate that endogenously released nociceptin may have a hitherto unexplored role in the functional modulation of the neural pathways that mediate vestibular reflexes in vivo.
Localization (released) of nociceptin in neural associated with orphanin
2) Confidence 0.80 Published 1999 Journal Brain Res. Section Abstract Doc Link 10320726 Disease Relevance 0.09 Pain Relevance 0.58
The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [(125)I-Tyr(14)]nociceptin. [(125)I-Tyr(14)]nociceptin appeared to interact with a single class of binding sites (K(D)=0.1 nM) present in the grey matter in all laminae of the spinal cord from cervical to sacral levels.
Localization (localization) of nociceptin in spinal cord associated with orphanin and spinal cord
3) Confidence 0.76 Published 1999 Journal Brain Res. Section Abstract Doc Link 10446320 Disease Relevance 0 Pain Relevance 0.45
The results show that nociceptin is metabolized step-wise in vivo into fragments (1-13) and (14-17) as well as (1-9) and (10-13), respectively.
Localization (metabolized) of nociceptin associated with orphanin
4) Confidence 0.75 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094136 Disease Relevance 0 Pain Relevance 0.47
Acetyl-RYYRIK-NH(2), like nociceptin and [Phe(1)Psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) and unlike naloxone benzoylhydrazone, decreased diastolic blood pressure and heart rate (rank order of potencies: nociceptin approximately equal to acetyl-RYYRIK-NH(2) >> [Phe(1)Psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2)).
Localization (decreased) of nociceptin in blood associated with pressure volume 2 under development, orphanin and narcan
5) Confidence 0.75 Published 2000 Journal Peptides Section Abstract Doc Link 11150649 Disease Relevance 0.17 Pain Relevance 0.78
Orphanin FQ/nociceptin is a physiological regulator of prolactin secretion in female rats.
Localization (secretion) of Orphanin FQ associated with orphanin
6) Confidence 0.73 Published 2006 Journal Endocrinology Section Title Doc Link 16887913 Disease Relevance 0 Pain Relevance 0.46
In accordance with the inhibitory effect of this peptide on locomotor activity, we now report that orphanin FQ suppresses dopamine release in the nucleus accumbens in a dose-dependent manner, providing the first neurochemical evidence for a modulatory role of this recently described peptide in the CNS.
Localization (release) of orphanin FQ in nucleus accumbens associated with nucleus accumbens, dopamine, orphanin and eae
7) Confidence 0.70 Published 1996 Journal Neuroscience Section Abstract Doc Link 8923516 Disease Relevance 0.07 Pain Relevance 1.21
This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.
Localization (released) of nociceptin in spinal cord associated with analgesic, orphanin and spinal cord
8) Confidence 0.70 Published 2001 Journal Neuroreport Section Abstract Doc Link 11388404 Disease Relevance 0.08 Pain Relevance 0.60
This suggested that paw formalin injection induced nociceptin release in the spinal cord and the supraspinal brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test.
Localization (release) of nociceptin in spinal cord associated with analgesic, orphanin and spinal cord
9) Confidence 0.70 Published 2001 Journal Neuroreport Section Abstract Doc Link 11388404 Disease Relevance 0.08 Pain Relevance 0.60
Orphanin FQ is a novel opioid family member, which is densely localized in the hypothalamus, a region of the brain important for the control of reproduction.
Localization (localized) of Orphanin FQ in brain associated with orphanin and opioid
10) Confidence 0.70 Published 2002 Journal Neuroreport Section Abstract Doc Link 12151779 Disease Relevance 0 Pain Relevance 0.30
The binding sites of nociceptin (also named orphanin FQ), the endogenous ligand of ORL1 (opiate receptor like 1), were localized in rat brain, using an autoradiographic procedure.
Localization (localized) of nociceptin in brain associated with orphanin and opiate
11) Confidence 0.69 Published 2000 Journal Brain Res. Section Abstract Doc Link 11032985 Disease Relevance 0 Pain Relevance 0.34
Autoradiographic localization of [3H]nociceptin binding sites in the rat brain.
Localization (localization) of nociceptin in brain associated with orphanin
12) Confidence 0.69 Published 2000 Journal Brain Res. Section Title Doc Link 11032985 Disease Relevance 0.06 Pain Relevance 0.50
Here, we report the localization of nociceptin-like immunoreactivity to fiber-like elements of the superficial layers of the rat dorsal horn by immunohistochemical techniques.
Localization (localization) of nociceptin in dorsal horn associated with orphanin and dorsal horn
13) Confidence 0.69 Published 1997 Journal Neuroscience Section Abstract Doc Link 9330354 Disease Relevance 0.09 Pain Relevance 0.74
[Phe(1)Psi(CH(2)-NH)Gly(2)]NC(1-13)NH(2) does not antagonize orphaninFQ/nociceptin-induced prolactin release.
Localization (release) of nociceptin associated with orphanin and narcan
14) Confidence 0.68 Published 2002 Journal Brain Res. Bull. Section Title Doc Link 11927375 Disease Relevance 0 Pain Relevance 0.44
The effects induced by nociceptin on morphine-induced release of dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) in the nucleus accumbens and nucleus caudate were studied in rats by microdialysis with electrochemical detection.
Localization (release) of nociceptin in nucleus accumbens associated with nucleus accumbens, dopamine, orphanin and morphine
15) Confidence 0.66 Published 2000 Journal Peptides Section Abstract Doc Link 10998547 Disease Relevance 0 Pain Relevance 0.75
Nociceptin decreased heart rate and in doses of 10 and 30 nmol/kg i.v., significantly decreased cardiac output.
Localization (decreased) of Nociceptin in heart associated with heart rate under development, orphanin and bradycardia
16) Confidence 0.65 Published 1997 Journal Peptides Section Abstract Doc Link 9213368 Disease Relevance 0.20 Pain Relevance 0.48
Acetyl-RYYRIK-NH(2), like nociceptin and [Phe(1)Psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) and unlike naloxone benzoylhydrazone, decreased diastolic blood pressure and heart rate (rank order of potencies: nociceptin approximately equal to acetyl-RYYRIK-NH(2) >> [Phe(1)Psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2)).
Localization (decreased) of nociceptin in blood associated with pressure volume 2 under development, orphanin and narcan
17) Confidence 0.65 Published 2000 Journal Peptides Section Abstract Doc Link 11150649 Disease Relevance 0.18 Pain Relevance 0.79
The effects induced by orphanin FQ (OFQ) on morphine-induced dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) release in the nucleus accumbens were studied in rats by using microdialysis with electrochemical detection.
Localization (release) of orphanin FQ in nucleus accumbens associated with nucleus accumbens, dopamine, orphanin and morphine
18) Confidence 0.63 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10505611 Disease Relevance 0 Pain Relevance 0.92
The secretion was significantly inhibited by the central injection of [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin-(1-13)-NH(2) ([F/G]nociceptin-(1-13), 0.21 nmol, an antagonist of ORL1 receptor), although [F/G]nociceptin-(1-13) alone at higher doses (2.10 and 7.31 nmol) markedly stimulated gastric acid secretion.
Localization (secretion) of nociceptin associated with antagonist and orphanin
19) Confidence 0.61 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12007927 Disease Relevance 0 Pain Relevance 1.00
In conclusion, nociceptin injected into the CNS stimulated gastric acid secretion in rats via the ORL1 receptors and through mechanisms involving the vagus nerve.
Localization (secretion) of nociceptin in vagus nerve associated with orphanin, central nervous system and vagus nerve
20) Confidence 0.61 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12007927 Disease Relevance 0 Pain Relevance 0.77

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