INT66423

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Context Info
Confidence 0.40
First Reported 1996
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 52
Total Number 54
Disease Relevance 61.63
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ELOVL1) endoplasmic reticulum (ELOVL1)
Anatomy Link Frequency
lung 4
internal 1
autonomic 1
central nervous system 1
nervous system 1
ELOVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 221 100.00 Very High Very High Very High
fibrosis 195 99.68 Very High Very High Very High
Pain 82 99.48 Very High Very High Very High
Central nervous system 35 98.96 Very High Very High Very High
antagonist 13 97.00 Very High Very High Very High
Inflammation 122 96.96 Very High Very High Very High
withdrawal 1 95.00 High High
rheumatoid arthritis 270 94.36 High High
fluoxetine 1 93.24 High High
abdominal pain 3 92.96 High High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 4289 100.00 Very High Very High Very High
Syndrome 446 100.00 Very High Very High Very High
Arthritis 142 100.00 Very High Very High Very High
Seronegative Spondarthritis 122 100.00 Very High Very High Very High
Erectile Dysfunction 66 100.00 Very High Very High Very High
Infection 62 100.00 Very High Very High Very High
Interstitial Lung Diseases 54 100.00 Very High Very High Very High
Pulmonary Disease 47 100.00 Very High Very High Very High
Esophageal Motility Disorder 9 100.00 Very High Very High Very High
Hypertension 54 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It indicates that there may be a weak association between solvent exposure and SSc, but that chance cannot be excluded as an explanation.
SSc Binding (association) of associated with systemic sclerosis
1) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.76 Pain Relevance 0.06
There was a nonsignificant association between SSc and work with aliphatic hydrocarbons (OR 2.1, 95% CI 0.8–5.5, based on six cases).
SSc Binding (association) of associated with systemic sclerosis
2) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.72 Pain Relevance 0.08
This study must be interpreted as providing inconclusive evidence of an association between SSc and solvent exposure.
SSc Binding (association) of associated with systemic sclerosis
3) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.86 Pain Relevance 0.06
This paper provides no conclusive evidence of an association between solvents and SSc.
SSc Neg (no) Binding (association) of associated with systemic sclerosis
4) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.84 Pain Relevance 0.04
It also provides no support for the conclusion that solvents are associated with SSc in women.
SSc Binding (associated) of associated with systemic sclerosis
5) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.78 Pain Relevance 0.17
This study suggests that solvent exposures are associated with SSc in men, but it gives no information on which chemicals or circumstances of exposure convey this risk.
SSc Binding (associated) of associated with systemic sclerosis
6) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.71 Pain Relevance 0.14
There was a statistically significant association between solvent exposure and SSc (OR 5.8, 95% CI 2.5–13.4).
SSc Binding (association) of associated with systemic sclerosis
7) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.97 Pain Relevance 0.04
Solvents were associated with SSc in men, but not in women.
SSc Binding (associated) of associated with systemic sclerosis
8) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.82 Pain Relevance 0.16
Other solvents were associated with SSc in men, but not statistically significantly (benzene exposure OR 2.4, 95% CI 0.8–7.1; trichloroethane OR 2.7, 95% CI not given).
SSc Binding (associated) of associated with systemic sclerosis
9) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.84 Pain Relevance 0.14
This study provides support for the conclusion that solvent exposure is associated with SSc in men (but not women), and that trichloroethylene specifically is associated with SSc.
SSc Binding (associated) of associated with systemic sclerosis
10) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.54 Pain Relevance 0.05
This study provides support for the conclusion that solvent exposure is associated with SSc in men (but not women), and that trichloroethylene specifically is associated with SSc.
SSc Binding (associated) of associated with systemic sclerosis
11) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.49 Pain Relevance 0
This paper supports the interpretation that there is a weak association between solvent exposure and SSc among women.
SSc Binding (association) of associated with systemic sclerosis
12) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.72 Pain Relevance 0.04
It is unlikely that the controls are representative of the general population from which the cases arose, and it is possible that selection bias may have altered the apparent association between SSc and solvent exposure.
SSc Binding (association) of associated with systemic sclerosis
13) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.92 Pain Relevance 0.04
There have been a number of reviews of the literature on chemicals and SSc, which contain detailed lists of the agents reported to be associated with SSc.
SSc Binding (associated) of associated with systemic sclerosis
14) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.76 Pain Relevance 0
In order to determine which of them may be correct, epidemiological studies have been undertaken to determine which solvents and which circumstances of exposure are associated with SSc and scleroderma.


SSc Binding (associated) of associated with systemic sclerosis
15) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.73 Pain Relevance 0.06
As a result, this paper provides no information on whether solvents are associated with SSc.
SSc Spec (whether) Binding (associated) of associated with systemic sclerosis
16) Confidence 0.40 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.49 Pain Relevance 0
There were statistically significant associations between SSc and paint thinners and removers (OR 1.96, 95% CI 1.46–2.62) and all solvents combined (OR 1.96, 95% CI 1.54–2.49).
SSc Binding (associations) of in 46-2 associated with systemic sclerosis
17) Confidence 0.31 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.62 Pain Relevance 0
There were statistically significant associations between SSc and paint thinners and removers (OR 2.73, 95% CI 1.80–4.16); mineral spirits, naphtha, or white spirits (OR 1.81, 95% CI 1.09–3.02); and all solvents combined (OR 2.32, 95% CI 1.61–3.34).
SSc Binding (associations) of associated with systemic sclerosis
18) Confidence 0.31 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 1.49 Pain Relevance 0
In addition, there were nonsignificant associations between SSc and trichloroethylene (OR 1.91, 95% CI 0.56–6.56) and xylene (OR 1.92, 95% CI 0.59–6.29).
SSc Binding (associations) of associated with systemic sclerosis
19) Confidence 0.31 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.60 Pain Relevance 0
The authors also found that the association between solvents and SSc was present only among those subjects who tested positive for anti-Scl-70 antibody, suggesting that solvents may bind to topoisomerase I and trigger an autoimmune response in susceptible individuals.
SSc Binding (association) of associated with systemic sclerosis
20) Confidence 0.31 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.78 Pain Relevance 0.12

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