INT66424

Context Info Confidence 0.32 First Reported 1996 Last Reported 2010 Negated 3 Speculated 3 Reported most in Body Documents 7 Total Number 11 Disease Relevance 2.33 Pain Relevance 2.33

transmembrane transport (SLC43A3)

Anatomy Link Frequency neuronal 1 SLC43A3 (Homo sapiens)

Pain Link Frequency Relevance Heat Electroencephalography 81 100.00 cocaine 25 100.00 anesthesia 7 99.16 alcohol 39 96.00 positron emission tomography 5 95.08 cannabis 17 93.12 Intracerebroventricular 2 93.12 Raphe 9 85.84 Pain 8 85.84 Somatosensory cortex 2 84.48

Disease Link Frequency Relevance Heat Sepsis 60 99.82 Erectile Dysfunction 8 99.44 Reprotox - General 1 2 99.44 Drug Induced Neurotoxicity 30 89.68 Pain 5 85.84 Cognitive Disorder 23 85.76 Unconsciousness 5 75.92 Sleep Disorders 2 74.24 Encephalopathy 46 68.28 Heart Rate Under Development 2 66.68

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Key:

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

Time of recording with respect to the menstrual cycle was not controlled, as previous studies have demonstrated that the EEG variables under study are not sensitive to time during the cycle [72].

Neg (not) Regulation (sensitive) of EEG

1) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2851592 Disease Relevance 0.15 Pain Relevance 0

According to the still prominent and robust neurophysiologic findings in Ecstasy users, the aim of the present study was to detect whether EEG activity is altered in an extended representative sample of former Ecstasy users.

Spec (whether) Regulation (altered) of EEG

2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990767 Disease Relevance 0.15 Pain Relevance 0.17

Whether the effects of cocaine on EEG activity and penile erection are mechanistically linked, however, remains to be fully elucidated.

Spec (Whether) Regulation (effects) of EEG associated with erectile dysfunction and cocaine

3) Confidence 0.23 Published 1996 Journal Synapse Section Abstract Doc Link 8923663 Disease Relevance 0.35 Pain Relevance 0.33

However, the same administration of cocaine in animals under pentobarbital sodium anesthesia (50 mg/kg, i.p.) failed to significantly affect EEG activity, despite an appreciable dose-dependent elevation in ICP.

Neg (failed) Regulation (affect) of EEG associated with anesthesia and cocaine

4) Confidence 0.23 Published 1996 Journal Synapse Section Abstract Doc Link 8923663 Disease Relevance 0.29 Pain Relevance 0.57

Pups aged 5-7 days exhibited no EEG response to clamping in view of their isoelectric traces.

Neg (no) Regulation (response) of EEG

5) Confidence 0.22 Published 2009 Journal Lab. Anim. Section Abstract Doc Link 19237459 Disease Relevance 0.14 Pain Relevance 0.21

Moreover, accounting for possible interactions with concurrent drugs ascertained the effect of Ecstasy on EEG spectral changes.

Regulation (effect) of EEG

6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990767 Disease Relevance 0.06 Pain Relevance 0.23

Thus, the clinical impact of these well reported altered EEG activities and our findings have to be considered with special interest.

Regulation (altered) of EEG

7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990767 Disease Relevance 0.16 Pain Relevance 0.24

The acquired electroencephalogram (EEG) data was analysed in four ways: (1) comparison of EEG topographic patterns and power spectra across baseline, CPT, and post-CPT; (2) dynamic EEG changes during CPT; (3) correlation of EEG activities at the isolated focal maxima across the three experimental stages; and (4) spatial correlation of EEG powers among the focal sites during CPT.

Regulation (changes) of EEG

8) Confidence 0.10 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 11927371 Disease Relevance 0.17 Pain Relevance 0.17

In order to remedy this Bojak et al. (2004) used the full set of Liley et al. (2002) equations to model the effects of anaesthetics on the EEG.

Regulation (effects) of EEG associated with electroencephalography

9) Confidence 0.01 Published 2008 Journal Cogn Neurodyn Section Body Doc Link PMC2585619 Disease Relevance 0.13 Pain Relevance 0.28

Interestingly, both serotype and LPS concentration of the latter study were different to our experimental protocol, suggesting that the observed effects on EEG activity are independent from these factors.

Spec (observed) Regulation (effects) of EEG

10) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2553764 Disease Relevance 0.39 Pain Relevance 0

In order to correlate the observed sepsis-induced changes in CBF and EEG to brain glucose utilization, a marker of neuronal activity, we assessed cerebral glucose uptake by 18F-fluordeoxyglucose positron emission tomography ([18F]FDG-PET) using a small animal scanner.

Regulation (changes) of EEG in neuronal associated with positron emission tomography and sepsis

11) Confidence 0.00 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2553764 Disease Relevance 0.35 Pain Relevance 0.14

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