INT66443

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PPP1R1A) carbohydrate metabolic process (PPP1R1A)
Anatomy Link Frequency
erythrocytes 2
knee 2
PPP1R1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 100.00 Very High Very High Very High
metalloproteinase 3 99.16 Very High Very High Very High
Osteoarthritis 1 96.96 Very High Very High Very High
Clonidine 1 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 100.00 Very High Very High Very High
Knee Osteoarthritis 1 97.16 Very High Very High Very High
Osteoarthritis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding studies with [3H]idazoxan and [3H]p-aminoclonidine did not reveal the expression of I1 and I2 binding sites in erythrocytes.
Neg (not) Regulation (reveal) of Gene_expression (expression) of I1 in erythrocytes
1) Confidence 0.35 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8925867 Disease Relevance 0 Pain Relevance 0.10
OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of PA inhibitor-1 in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis
2) Confidence 0.09 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47

General Comments

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