INT6645

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 22
Disease Relevance 12.17
Pain Relevance 13.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (BDKRB1) plasma membrane (BDKRB1) signal transducer activity (BDKRB1)
Anatomy Link Frequency
smooth muscle cells 1
skin 1
uterine 1
BDKRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 745 100.00 Very High Very High Very High
B1 receptor 172 100.00 Very High Very High Very High
b2 receptor 106 100.00 Very High Very High Very High
antagonist 28 99.70 Very High Very High Very High
Pain 285 99.66 Very High Very High Very High
chemokine 18 99.52 Very High Very High Very High
Inflammation 242 99.36 Very High Very High Very High
cytokine 50 98.92 Very High Very High Very High
acular 189 98.88 Very High Very High Very High
Eae 135 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 298 99.70 Very High Very High Very High
INFLAMMATION 251 99.36 Very High Very High Very High
Pain 302 98.92 Very High Very High Very High
Stress 306 98.44 Very High Very High Very High
Inflammatory Pain 118 98.36 Very High Very High Very High
Disease 579 98.00 Very High Very High Very High
Neuropathic Pain 9 94.08 High High
Nociception 19 92.36 High High
Hyperalgesia 18 91.52 High High
Frailty 18 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are known to upregulate B1 receptor both in-vitro [32] and in-vivo [15], we hypothesize that the up-regulation of both IL-1?
Positive_regulation (upregulate) of B1 receptor associated with b1 receptor
1) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.88 Pain Relevance 0.70
Several mechanisms have been suggested to induce B1 receptor up-regulation in response to inflammation.
Positive_regulation (induce) of B1 receptor associated with inflammation and b1 receptor
2) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.87 Pain Relevance 0.77
Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin.
Positive_regulation (activation) of bradykinin B1 in skin associated with pain, b2 receptor and bradykinin
3) Confidence 0.61 Published 2004 Journal Pain Section Title Doc Link 15275768 Disease Relevance 0.64 Pain Relevance 1.04
Although both desArg(10)KD and BK increased the level of IL-1beta mRNA, IL-1beta receptor antagonist inhibited the increase in B1R only in response to BK.
Positive_regulation (increase) of B1R associated with antagonist and bradykinin
4) Confidence 0.60 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.21 Pain Relevance 0.82
The bradykinin B1 receptor is induced following tissue injury and/or inflammation.
Positive_regulation (induced) of B1 receptor associated with inflammation, b1 receptor and injury
5) Confidence 0.59 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17408249 Disease Relevance 0.29 Pain Relevance 0.39
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Positive_regulation (favor) of B1R
6) Confidence 0.50 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.27 Pain Relevance 0.77
Further, the correlation between pain intensity and gene expression level reported here, argues in favor of a functional relationship between tissue injury and increased BK receptor activation leading to an increase in pain.
Positive_regulation (activation) of BK receptor associated with pain, injury and bradykinin
7) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.90 Pain Relevance 0.92
The importance of B1 receptor lies in the role that it plays in maintaining inflammation in chronic pain states, in contrast to the B2 receptor that is quickly desensitized.
Positive_regulation (importance) of B1 receptor associated with inflammation, lasting pain, b1 receptor and b2 receptor
8) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.88 Pain Relevance 0.75
Chemical chaperones stabilized all B1R-YFP species and up-regulated endogenous B1 receptors expressed at the surface of rabbit smooth muscle cells.
Positive_regulation (stabilized) of B1R-YFP in smooth muscle cells
9) Confidence 0.44 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16407468 Disease Relevance 0.10 Pain Relevance 0.38
B1 receptor activation contributes to the development of acute inflammatory pain possibly via the activation of TRPV1.


Positive_regulation (activation) of B1 receptor associated with eae and b1 receptor
10) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.58 Pain Relevance 0.51
In conclusion, we propose here that B1 receptor is upregulated early following tissue injury in man, possibly in response to kinin activation, and cytokines and chemokines secretion.
Spec (possibly) Positive_regulation (upregulated) of B1 receptor associated with chemokine, b1 receptor, injury and cytokine
11) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.60 Pain Relevance 0.55
It is generally accepted that the B2 receptor is constitutively expressed, whereas the B1 receptor is induced in response to inflammation.
Positive_regulation (induced) of B1 receptor associated with inflammation, b1 receptor and b2 receptor
12) Confidence 0.44 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 0.98 Pain Relevance 0.64
The inducible kinin B1 receptor is emerging as an attractive therapeutic target for the treatment of pain and inflammation.
Positive_regulation (inducible) of B1 receptor associated with pain, inflammation and b1 receptor
13) Confidence 0.42 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16407468 Disease Relevance 0.19 Pain Relevance 0.31
Concomitantly, BK increased B1R (2- to 3-fold) with a T(1/2) of 120 min.
Positive_regulation (increased) of B1R associated with bradykinin
14) Confidence 0.40 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.26 Pain Relevance 0.81
DesArg(10)KD (100 nM) had no effect on B2R but increased B1R (3- to 4-fold) with the same rate as BK.
Positive_regulation (increased) of B1R associated with bradykinin
15) Confidence 0.40 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.24 Pain Relevance 0.83
DesArg(10)KD and BK synergistically increased B1R (9-fold), which was further increased by inclusion of IL-1beta (36-fold).
Positive_regulation (increased) of B1R associated with bradykinin
16) Confidence 0.40 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.20 Pain Relevance 0.81
BDKRB1 was 2.5-fold upregulated in the placebo treated group (p < 0.0001; paired t-test; n = 15) and 2.4-fold upregulated in the ketorolac treatment group (p < 0.0001; paired t-test; n = 15).
Positive_regulation (upregulated) of BDKRB1 associated with acular
17) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.48 Pain Relevance 0.71
Both BDKRB1 and BDKRB2 were significantly upregulated 3 hours following tissue injury in both the placebo and ketorolac treatment group (Table 1).
Positive_regulation (upregulated) of BDKRB1 associated with injury and acular
18) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.50 Pain Relevance 0.78
PS-1 mutation appears to exert a greater severity at several levels of BK signaling than the homologous PS-2 mutation, from BKB2R modulation to ERK activation.
Positive_regulation (modulation) of BKB2R associated with bradykinin
19) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.85 Pain Relevance 0.34
The site-specific differences in BKB2R signal strength we observe parallel the degree to which the PS-1 mutation is an aggressive one, reflected in both an earlier age of onset of the disease and in secretion of A?
Positive_regulation (differences) of BKB2R associated with disease
20) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.49 Pain Relevance 0.03

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