INT66461

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Context Info
Confidence 0.21
First Reported 1996
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.44
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppia) protein folding (Ppia) cytosol (Ppia)
nucleus (Ppia) cytoplasm (Ppia)
Anatomy Link Frequency
NFAT 1
Ppia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 96.04 Very High Very High Very High
qutenza 8 91.44 High High
dorsal root ganglion 2 75.00 Quite High
fibrosis 15 63.52 Quite High
Paracetamol 3 17.52 Low Low
metalloproteinase 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 30 82.96 Quite High
Cirrhosis 108 80.48 Quite High
Ganglion Cysts 2 75.00 Quite High
Injury 3 65.80 Quite High
Apoptosis 27 59.28 Quite High
Disease Progression 6 58.24 Quite High
Fibrosis 9 49.76 Quite Low
Hepatitis 6 23.56 Low Low
Necrosis 3 15.76 Low Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desensitization is greatly reduced by cyclosporin A complexed to cyclophilin, which is a specific inhibitor of protein phoshatase 2B (calcineurin).
cyclophilin Binding (complexed) of
1) Confidence 0.21 Published 1996 Journal Pflugers Arch. Section Abstract Doc Link 8927498 Disease Relevance 0.15 Pain Relevance 0.60
Because NIM811 lacks the ability to bind to cyclophilin A (13), NIM811 exerts its pharmacological effects by binding to other cyclophilins, such as cyclophilin B or D.
cyclophilin Binding (bind) of
2) Confidence 0.02 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.11 Pain Relevance 0
NIM811 is a four-substituted cyclosporine that does not bind to cyclophilin A and therefore lacks immunosuppressive activity; however, it retains the ability to bind other cyclophilins, such as cyclophilin B (13).
cyclophilin Neg (not) Binding (bind) of
3) Confidence 0.02 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.80 Pain Relevance 0.05
NIM811, an analogue of cyclosporine, does not activate the NFAT pathway because it cannot bind to cyclophilin A (13).
cyclophilin Neg (cannot) Binding (bind) of in NFAT
4) Confidence 0.02 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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