INT66469

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.32
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj6) Golgi apparatus (Kcnj6) plasma membrane (Kcnj6)
cytoplasm (Kcnj6)
Anatomy Link Frequency
brain 2
oocytes 2
Kcnj6 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 3 99.28 Very High Very High Very High
sSRI 3 99.06 Very High Very High Very High
Hippocampus 4 93.96 High High
cerebral cortex 4 93.44 High High
Desipramine 1 89.28 High High
antidepressant 5 86.36 High High
Thalamus 2 85.68 High High
Ventral tegmentum 2 83.92 Quite High
Substantia nigra 2 81.32 Quite High
depression 1 78.36 Quite High
Disease Link Frequency Relevance Heat
Death 3 95.56 Very High Very High Very High
Depression 1 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In regions where GIRK1 and GIRK2 distributions overlap, both GIRK1 and GIRK2 expressions are severely disrupted, probably because of their co-assembly.
Negative_regulation (disrupted) of Gene_expression (expressions) of GIRK2
1) Confidence 0.58 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.52
In the brain of the wv mouse, GIRK2 expression is decreased dramatically.
Negative_regulation (decreased) of Gene_expression (expression) of GIRK2 in brain
2) Confidence 0.58 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8929423 Disease Relevance 0 Pain Relevance 0.55
First, we found that a widely used SSRI fluoxetine (also known as Prozac) effectively inhibited wv GIRK2 channels like wild-type GIRK channels, expressed in Xenopus oocytes.
Negative_regulation (inhibited) of Gene_expression (expressed) of GIRK2 in oocytes associated with ssri and fluoxetine
3) Confidence 0.50 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16310876 Disease Relevance 0.32 Pain Relevance 0.70

General Comments

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