INT66491

Context Info Confidence 0.45 First Reported 1996 Last Reported 2008 Negated 0 Speculated 3 Reported most in Abstract Documents 2 Total Number 5 Disease Relevance 1.51 Pain Relevance 0.86

endoplasmic reticulum (CES2) catabolic process (CES2)

CES2 (Homo sapiens)

Pain Link Frequency Relevance Heat cocaine 14 97.88 Morphine 12 88.88 Analgesic 1 45.12 imagery 7 5.00 palliative 1 5.00 ketamine 1 5.00 Perioperative pain 1 5.00 lidocaine 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Small Cell Lung Cancer 32 99.24 Non-small-cell Lung Cancer 27 98.64 Cancer 51 97.92 Malignant Neoplastic Disease 3 83.64 Necrosis 9 77.84 Photosensitivity Disorders 7 50.00 Small Cell Lung Carcinoma 7 50.00 Lung Cancer 9 5.00 Sunburn 3 5.00 Cleidocranial Dysplasia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

EU019538), and found that 33 nucleotides in the predicted sequence were absent in the CES2.2 cDNA sequence.

Regulation (absent) of CES2.2

1) Confidence 0.45 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0

This investigation examined the relative catalytic efficiencies of hCE-1, hCE-2 and pseudocholinesterase for heroin metabolism and compared them with cocaine hydrolysis.

Spec (examined) Regulation (efficiencies) of hCE-1 associated with cocaine

2) Confidence 0.31 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930175 Disease Relevance 0 Pain Relevance 0.43

This investigation examined the relative catalytic efficiencies of hCE-1, hCE-2 and pseudocholinesterase for heroin metabolism and compared them with cocaine hydrolysis.

Spec (examined) Regulation (efficiencies) of hCE-2 associated with cocaine

3) Confidence 0.31 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930175 Disease Relevance 0 Pain Relevance 0.43

These findings shed some light on CES2 gene regulation, a gene important in the metabolism of many drugs.

Regulation (regulation) of CES2

4) Confidence 0.27 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12835618 Disease Relevance 0.09 Pain Relevance 0

To determine the efficacy of Ce6-PVP mediated PDT, nude mice bearing NSCLC and SCLC tumors were administered with 2.0 mg/kg of the photosensitizer.

Spec (determine) Regulation (efficacy) of Ce6 associated with cancer, non-small-cell lung cancer and small cell lung cancer

5) Confidence 0.01 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2212622 Disease Relevance 1.41 Pain Relevance 0

General Comments

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