INT66492

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.73
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
liver 1
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 9 99.70 Very High Very High Very High
Potency 3 97.44 Very High Very High Very High
Morphine 6 95.44 Very High Very High Very High
lidocaine 5 76.00 Quite High
algil 2 75.56 Quite High
methotrexate 4 57.16 Quite High
cytokine 9 37.60 Quite Low
Glutamate 8 33.84 Quite Low
Paracetamol 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 48 93.96 High High
Adenocarcinoma 3 92.00 High High
Cytomegalovirus Infection 1 85.28 High High
Cancer 62 69.04 Quite High
Severe Combined Immunodeficiency 14 50.00 Quite Low
Suicidal Behaviour 7 50.00 Quite Low
Neuroblastoma 2 40.72 Quite Low
Breast Cancer 8 36.84 Quite Low
Hematological Disease 3 21.04 Low Low
Colon Cancer 16 5.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-PCR studies reported earlier for opossum CES1, CES2, CES2.2 and CES2.3 genes confirm the existence, expression and sequences for CES coding regions for these opossum genes.
Negative_regulation (opossum) of CES2
1) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The RT-PCR studies reported earlier for opossum CES1, CES2, CES2.2 and CES2.3 genes confirm the existence, expression and sequences for CES coding regions for these opossum genes.
Negative_regulation (opossum) of CES2.2
2) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The RT-PCR studies reported earlier for opossum CES1, CES2, CES2.2 and CES2.3 genes confirm the existence, expression and sequences for CES coding regions for these opossum genes.
Negative_regulation (opossum) of CES2
3) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Cocaine competitively inhibited hCE-1-, hCE-2- and pseudocholinesterase-catalyzed hydrolysis of heroin to 6-monoacetylmorphine (Ki = 530, 460 and 130 microM, respectively) and 6-monoacetylmorphine hydrolysis to morphine (Ki = 710, 220 and 830 microM, respectively).
Negative_regulation (inhibited) of hCE-1 associated with morphine and cocaine
4) Confidence 0.29 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930175 Disease Relevance 0 Pain Relevance 0.57
There was a 1.25 fold reduction in the ICE/casp1 mRNA in the test cells compared to control.
Negative_regulation ( fold red) of ICE
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.30 Pain Relevance 0
While the isatin analogues were generally less effective at CE inhibition than the benzils, the former may represent valid lead compounds for the development of inhibitors for use in modulating drug metabolism in vivo.
Negative_regulation (inhibition) of CE
6) Confidence 0.06 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17378546 Disease Relevance 0 Pain Relevance 0.16
Biochemical assays and kinetic studies demonstrated that isatins (indole-2,3-diones), containing hydrophobic groups attached at a variety of positions within these molecules, could act as potent, specific CE inhibitors.
Negative_regulation (inhibitors) of CE
7) Confidence 0.06 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17378546 Disease Relevance 0 Pain Relevance 0.20
However, human CE is relatively poor at activating IRT, with rabbit liver CE being 100–1000-fold more efficient [110].
Negative_regulation (poor) of CE in liver
8) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.44 Pain Relevance 0.03

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