INT66504

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Context Info
Confidence 0.39
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.78
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Agt, Agtr1a) endosome (Agtr1a) extracellular space (Agt)
extracellular region (Agt) Golgi apparatus (Agtr1a) plasma membrane (Agtr1a)
Anatomy Link Frequency
nucleus 1
lung 1
hippocampus 1
Agt (Rattus norvegicus)
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
ischemia 2 99.28 Very High Very High Very High
Hippocampus 8 96.64 Very High Very High Very High
antinociception 5 95.52 Very High Very High Very High
bradykinin 6 94.08 High High
Kinase C 2 88.52 High High
medulla 1 87.36 High High
Catecholamine 8 84.56 Quite High
Bioavailability 3 78.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 100.00 Very High Very High Very High
Cv General 4 Under Development 2 99.28 Very High Very High Very High
Cough 6 97.12 Very High Very High Very High
Increased Venous Pressure Under Development 10 92.76 High High
Myocardial Infarction 50 91.12 High High
Injury 3 90.80 High High
Cardiovascular Disease 4 89.20 High High
Apoptosis 12 81.92 Quite High
Left Ventricular Hypertrophy 8 80.68 Quite High
Hypoxia 108 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The octapeptide angiotensin II (AngII) regulates vascular tone and stimulates the release of pro-inflammatory cytokines by acting through the AT1 and AT2 receptors.
angiotensin II Binding (acting) of AT1 associated with inflammation and cytokine
1) Confidence 0.39 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.59 Pain Relevance 0.34
The octapeptide angiotensin II (AngII) regulates vascular tone and stimulates the release of pro-inflammatory cytokines by acting through the AT1 and AT2 receptors.
AngII Binding (acting) of AT1 associated with inflammation and cytokine
2) Confidence 0.39 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.59 Pain Relevance 0.34
Ang II is a potent vasopressor that exerts its effects by binding to G-protein receptors, AT1R and AT2R, which are broadly distributed in the brain and particularly dense in the hippocampus [23].
Ang II Binding (binding) of AT1R in hippocampus associated with hippocampus
3) Confidence 0.27 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.69 Pain Relevance 0.25
Although we can not rule out the possibility that Ang IV may directly activate the AT1 receptor with a dosage of exogenous Ang IV in the micromolar range, our binding studies with Sarile did not support the interpretation of such a non-specific binding of Ang IV to the AT1 receptor.
Ang IV Binding (binding) of AT1 receptor
4) Confidence 0.25 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.42 Pain Relevance 0.07
Nevertheless, the functional significance of the AT4 receptor expression may not be fully reflected by the [Ca2+]i response induced by Ang IV and the details of the Ang IV action and possible interaction with the AT1 receptors and its signaling cascades await elucidation by further studies.
Ang IV Binding (interaction) of AT1
5) Confidence 0.25 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.44 Pain Relevance 0.04
Participation of AT1 and AT2 receptors in the differential interaction between angiotensin II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats.
angiotensin II Binding (interaction) of AT1 in nucleus associated with antinociception
6) Confidence 0.19 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8930186 Disease Relevance 0.15 Pain Relevance 0.42
ARBs act by a different mechanism than ACE inhibitors by blocking the binding of angiotensin II to the AT1 receptor (Goodfriend et al 1996).
angiotensin II Binding (binding) of AT1 receptor
7) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.89 Pain Relevance 0.26
It inhibits the binding of labeled angiotensin II to AT1 receptors in rat lung with a Ki of 3.7 nmol/L (Wienen et al 1993).
angiotensin II Binding (binding) of AT1 in lung
8) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0.06

General Comments

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