INT66519

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.61
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
hippocampus 4
Semen 2
midbrain 2
frontal cortex 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 100.00 Very High Very High Very High
fluoxetine 17 99.98 Very High Very High Very High
depression 24 99.68 Very High Very High Very High
Endep 8 99.56 Very High Very High Very High
midbrain 3 98.28 Very High Very High Very High
Serotonin 3 96.08 Very High Very High Very High
agonist 6 95.32 Very High Very High Very High
antidepressant 5 91.12 High High
tricyclic antidepressant 6 86.32 High High
Raphe 2 85.60 High High
Disease Link Frequency Relevance Heat
Depression 24 99.68 Very High Very High Very High
Stress 42 99.32 Very High Very High Very High
Urological Neuroanatomy 8 97.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the I to II regions of the frontal cortex, N.s. and H.p. also reversed the CMS-induced decrease in 5-HT1A receptor binding, and even showed a significant increase in 5-HT1A receptor binding compared to the F treatment group (N.s. vs.
Positive_regulation (increase) of 5-HT1A Binding (binding) of in frontal cortex associated with stress and urological neuroanatomy
1) Confidence 0.67 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.42 Pain Relevance 0.42
It is concluded that N.s. presents an anti-depression effect through enhancing 5-HT1A receptor binding.
Positive_regulation (enhancing) of 5-HT1A Binding (binding) of associated with depression
2) Confidence 0.67 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 1.08 Pain Relevance 0.26
Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom.
Positive_regulation (induced) of 5-HT1A Binding (binding) of in Semen associated with stress and depression
3) Confidence 0.67 Published 2004 Journal Arch. Pharm. Res. Section Title Doc Link 15554266 Disease Relevance 1.05 Pain Relevance 0.50
Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.
Positive_regulation (induces) of 5-HT1A Binding (desensitization) of in midbrain associated with agonist, midbrain and fluoxetine
4) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8930214 Disease Relevance 0.06 Pain Relevance 0.53
Chronic administration of amitriptyline resulted in a marked increase in 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus which was accompanied by an increase in 5-HT1A receptor number. 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus was also increased by chronic treatment with the highest dose of venlafaxine; 5-HT1A receptor number, however, was not significantly altered.
Positive_regulation (increase) of 5-HT1A Binding (binding) of in hippocampus associated with hippocampus and endep
5) Confidence 0.49 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035959 Disease Relevance 0 Pain Relevance 0.55
Chronic administration of amitriptyline resulted in a marked increase in 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus which was accompanied by an increase in 5-HT1A receptor number. 5-HT1A receptor-stimulated [35S]GTPgammaS binding in the hippocampus was also increased by chronic treatment with the highest dose of venlafaxine; 5-HT1A receptor number, however, was not significantly altered.
Positive_regulation (increased) of 5-HT1A Binding (binding) of in hippocampus associated with hippocampus and endep
6) Confidence 0.49 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035959 Disease Relevance 0 Pain Relevance 0.55

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