INT66527

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Context Info
Confidence 0.31
First Reported 1996
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.47
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npy2r)
Anatomy Link Frequency
blood 1
Npy2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 98.58 Very High Very High Very High
tetrodotoxin 9 95.84 Very High Very High Very High
agonist 5 92.92 High High
vagus nerve 1 86.96 High High
Neuropeptide 4 75.00 Quite High
Pyramidal cell 3 75.00 Quite High
Hippocampus 2 75.00 Quite High
Glutamate 1 71.92 Quite High
excitatory amino acid 1 65.52 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.90 Very High Very High Very High
Bradycardia 3 84.20 Quite High
Increased Venous Pressure Under Development 1 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PYY effect seems mainly carried out through Y2-receptor activation.
Spec (seems) Positive_regulation (activation) of Y2-receptor
1) Confidence 0.31 Published 1999 Journal Peptides Section Abstract Doc Link 10503778 Disease Relevance 0 Pain Relevance 0.32
To directly compare the effects of Y2 receptor activation on sEPSC and mEPSC properties, we applied [ahx5-24]NPY to the same cell in the absence and presence of TTX (n = 7). sEPSC intervals were characteristically increased by the Y2 agonist in all cells; in six of seven cells the sEPSC distribution was also shifted to smaller amplitudes.
Positive_regulation (activation) of Y2 receptor associated with tetrodotoxin and agonist
2) Confidence 0.22 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8930263 Disease Relevance 0 Pain Relevance 0.96
In the guinea pig, the Y2-receptor-preferring fragment NPY(3-36) and the selective Y1-receptor antagonist H 409/22 were used to confirm that the increase in blood pressure was mediated solely through the Y1-receptor and the vagal inhibition solely through the Y2-receptor.
Positive_regulation (mediated) of Y2-receptor in blood associated with pressure and volume under development and antagonist
3) Confidence 0.08 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11026645 Disease Relevance 0.47 Pain Relevance 0.16

General Comments

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