INT66532

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 46
Total Number 50
Disease Relevance 14.99
Pain Relevance 41.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
plasma 3
neurons 3
heart 3
spinal cord 2
neuronal 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 381 100.00 Very High Very High Very High
Pain 91 100.00 Very High Very High Very High
Opioid 66 100.00 Very High Very High Very High
Inflammation 27 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
Neuropeptide 19 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
gABA 7 100.00 Very High Very High Very High
Potency 6 100.00 Very High Very High Very High
c fibre 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 86 100.00 Very High Very High Very High
Pressure And Volume Under Development 13 100.00 Very High Very High Very High
Nociception 26 99.98 Very High Very High Very High
Coronary Artery Disease 2 99.98 Very High Very High Very High
INFLAMMATION 22 99.72 Very High Very High Very High
Leukemia 2 99.62 Very High Very High Very High
Hypertension 2 99.44 Very High Very High Very High
Ganglion Cysts 9 99.36 Very High Very High Very High
Neuropathic Pain 19 99.08 Very High Very High Very High
Depression 3 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the cardiovascular effects of nociceptin were mediated by activation of specific nociceptin receptors rather than typical naloxone-sensitive opioid receptors.
Positive_regulation (activation) of nociceptin associated with orphanin, narcan and opioid receptor
1) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350539 Disease Relevance 0.15 Pain Relevance 1.18
Pharmacological activation of nociceptin receptors with a unilateral injection of synthetic nociceptin into the NTS, wherein injection of L-glutamate (1 nmol) caused typical depressor responses, elevated blood pressure and heart rate (HR) in most of the anesthetized rats.
Positive_regulation (activation) of nociceptin in heart associated with pressure and volume under development, glutamate and orphanin
2) Confidence 0.69 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10871320 Disease Relevance 0.35 Pain Relevance 0.35
We suggest that elevated plasma nociceptin level is the consequence of stroke as in the group of patients recovered from previous stroke was found similar the control value.
Positive_regulation (elevated) of plasma nociceptin in plasma associated with stroke and orphanin
3) Confidence 0.67 Published 2006 Journal Neuropsychopharmacol Hung Section Abstract Doc Link 17073212 Disease Relevance 0.78 Pain Relevance 0.47
Therefore, the activation of the endogenous nociceptin/orphanin FQ system, which is known to exhibit antiopioidergic activity, apart from its analgesic action, could be the reason for lower responsiveness to morphine in neuropathic pain.
Positive_regulation (activation) of orphanin FQ associated with analgesic, orphanin, neuropathic pain and morphine
4) Confidence 0.67 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159147 Disease Relevance 0.57 Pain Relevance 1.72
Prepronociceptin (ppN/OFQ) mRNA has been shown to be upregulated by an increase in cAMP, a treatment that leads to differentiation of NS20Y neuroblastoma cells.
Positive_regulation (upregulated) of Prepronociceptin in NS20Y associated with neuroblastoma
5) Confidence 0.67 Published 2006 Journal Gene Section Abstract Doc Link 16935438 Disease Relevance 0.10 Pain Relevance 0.19
Our data suggest that nociceptin/orphanin FQ increases glutamate extracellular levels in the substantia nigra pars reticulata via activation of nociceptin/orphanin FQ receptors located on non-glutamatergic, possibly dopaminergic and GABAergic, neuronal elements.
Spec (possibly) Positive_regulation (activation) of nociceptin in neuronal associated with glutamate, gabaergic, substantia nigra and orphanin
6) Confidence 0.67 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044480 Disease Relevance 0 Pain Relevance 1.51
Our data suggest that nociceptin/orphanin FQ increases glutamate extracellular levels in the substantia nigra pars reticulata via activation of nociceptin/orphanin FQ receptors located on non-glutamatergic, possibly dopaminergic and GABAergic, neuronal elements.
Spec (possibly) Positive_regulation (activation) of orphanin FQ in neuronal associated with glutamate, gabaergic, substantia nigra and orphanin
7) Confidence 0.67 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044480 Disease Relevance 0 Pain Relevance 1.51
Two micro-opioid receptor agonists, morphine and endomorphin-1, whose effectiveness in neuropathic pain is different, also disparately influenced nociceptin/orphanin FQ system in this pain model, inasmuch as an increase in pronociceptin/orphanin FQ and ORL1 receptor mRNAs was observed in laminae I-VI after morphine administration (5 microg i.t.) but not after endomorphin-1 treatment (5 microg i.t.).
Positive_regulation (increase) of orphanin FQ associated with pain, orphanin, neuropathic pain, agonist, opioid receptor and morphine
8) Confidence 0.67 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159147 Disease Relevance 0.52 Pain Relevance 1.70
The inhibitory rates were 37+/-7, 43+/-6 and 57+/-11%, respectively, which were enhanced with an increase in the concentration of nociceptin.
Positive_regulation (increase) of nociceptin associated with orphanin
9) Confidence 0.60 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15224144 Disease Relevance 0.79 Pain Relevance 1.04
Like nociceptin, microinjection of endomorphin-1 (EM-1), an endogenous ligand for the opioid mu receptor, into the rostral NTS increased blood pressure and heart rate in a dose-dependent manner (0.04, 0.2, and 1 nmol).
Positive_regulation (increased) of nociceptin in heart associated with pressure and volume under development, orphanin and opioid
10) Confidence 0.57 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857705 Disease Relevance 0.39 Pain Relevance 1.06
Continuous intrathecal infusion of morphine produced a tolerance accompanied by a significant increase in nociceptin site density in the superficial layers.
Positive_regulation (increase) of nociceptin associated with orphanin, tolerance, morphine and intrathecal
11) Confidence 0.57 Published 1999 Journal Brain Res. Section Abstract Doc Link 10446320 Disease Relevance 0 Pain Relevance 0.89
The effect of the kappa-agonist [(+)-(5alpha,7alpha, 8beta)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4, 5)dec-8-yl)-benzeneacetamide] (U69593) was unchanged, whereas the effect of nociceptin was increased.
Positive_regulation (increased) of nociceptin associated with orphanin and agonist
12) Confidence 0.51 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822729 Disease Relevance 0.50 Pain Relevance 1.68
This study examined the vasodilator action of nociceptin, an endogenous opioid receptor-like ligand (ORL1), in thiobutabarbital-anesthetized rats, via the triple-isotope microspheres technique.
Spec (examined) Positive_regulation (action) of nociceptin associated with orphanin and endogenous opioid
13) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12208319 Disease Relevance 0 Pain Relevance 0.33
More precisely, supraspinal Nocistatin by itself had no significative effect on nociception and opioid analgesia in the tail flick test but, at the dose of 0.5ng/rat, it reversed the nociceptive effect of Nociceptin and also the antagonistic effect of Nociceptin against analgesia caused by the selective opioid agonists: DAMGO, DPDPE, Deltorphin II and U50 488H.
Positive_regulation (effect) of Nociceptin in tail associated with nociception, mu agonist, orphanin, tail-flick, opioid and analgesia
14) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16006036 Disease Relevance 0.45 Pain Relevance 1.63
The effects of nociceptin (orphanin FQ) on the excitability of electrophysiologically-identified oxytocin and vasopressin neurons were investigated in rat hypothalamic supraoptic nucleus slices in vitro, using whole-cell patch-clamp recording techniques.
Positive_regulation (effects) of nociceptin in neurons associated with orphanin
15) Confidence 0.50 Published 1998 Journal Neuroscience Section Abstract Doc Link 9579793 Disease Relevance 0 Pain Relevance 0.24
Moreover, the cardiovascular responses to exogenous nociceptin were mediated through activation of specific nociceptin receptors rather than typical naloxone-sensitive opioid receptors.
Positive_regulation (activation) of nociceptin associated with orphanin, narcan and opioid receptor
16) Confidence 0.50 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10871320 Disease Relevance 0.32 Pain Relevance 0.61
Antisera were generated against nociceptin/orphanin FQ, the putative ligand of the opioid receptor-like ORL1 receptor.
Positive_regulation (generated) of orphanin FQ associated with orphanin and opioid receptor
17) Confidence 0.49 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116232 Disease Relevance 0.14 Pain Relevance 0.88
These results suggest that the analgesic action of nociceptin might be mediated by direct postsynaptic inhibition within the dorsal horn.
Spec (might) Positive_regulation (mediated) of nociceptin in dorsal horn associated with orphanin, analgesic and dorsal horn
18) Confidence 0.48 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234781 Disease Relevance 0 Pain Relevance 0.48
Opioid receptor-like protein ORL1, the receptor for the neuropeptide nociceptin (also named orphanin FQ), has two alternatively spliced isoforms in the rat.
Positive_regulation (named) of orphanin FQ associated with orphanin, neuropeptide and opioid receptor
19) Confidence 0.47 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.24
Opioid receptor-like protein ORL1, the receptor for the neuropeptide nociceptin (also named orphanin FQ), has two alternatively spliced isoforms in the rat.
Positive_regulation (named) of nociceptin associated with orphanin, neuropeptide and opioid receptor
20) Confidence 0.47 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.24

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