INT66535

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 43
Total Number 46
Disease Relevance 5.93
Pain Relevance 32.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
neurons 3
brain 3
spinal cord 1
brain stem 1
CNS 1
Pnoc (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 374 100.00 Very High Very High Very High
Opioid 78 100.00 Very High Very High Very High
opioid receptor 65 100.00 Very High Very High Very High
narcan 18 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
antagonist 32 99.68 Very High Very High Very High
agonist 53 99.66 Very High Very High Very High
Central nervous system 9 99.28 Very High Very High Very High
butorphanol 1 98.86 Very High Very High Very High
Spinal cord 23 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 98.12 Very High Very High Very High
Appetite Loss 4 96.08 Very High Very High Very High
Nociception 32 95.84 Very High Very High Very High
Hyperalgesia 10 95.12 Very High Very High Very High
Depression 4 94.40 High High
Pain 9 93.52 High High
INFLAMMATION 4 89.12 High High
Asthma 6 88.28 High High
Affective Disorder 4 87.60 High High
Stress 5 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin is a preferred endogenous ligand for the orphan opioid receptor-like 1 (ORL1) receptor.
Nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid receptor
1) Confidence 0.54 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12007927 Disease Relevance 0 Pain Relevance 0.46
In transfected mammalian cells, the full-length ORL1 displays high-affinity and selective binding for nociceptin, and inhibits the production of cyclic AMP.
nociceptin Binding (binding) of ORL1 associated with orphanin
2) Confidence 0.53 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.43
In conclusion, the present study has shown that [3H]nociceptin binds selectively to ORL1 receptors in the rat brain and spinal cord.
nociceptin Binding (binds) of ORL1 in brain associated with orphanin and spinal cord
3) Confidence 0.46 Published 2001 Journal Biol. Pharm. Bull. Section Abstract Doc Link 11510482 Disease Relevance 0 Pain Relevance 1.02
In contrast, the truncated ORL1 binds nociceptin and other opioid peptides very poorly and non-selectively (affinity in micromolar range), and it does not mediate any inhibitory effects on cyclic AMP production.
nociceptin Binding (binds) of ORL1 associated with orphanin and opioid
4) Confidence 0.46 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.44
Apparently, this truncated ORL1 does not function as a receptor for nociceptin or other ligands tested.
nociceptin Binding (receptor) of ORL1 associated with orphanin
5) Confidence 0.46 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.42
The heptadecapeptide, orphanin FQ/nociceptin (OFQ/N), binds with high affinity to the ORL-1/KOR-3 opioid receptor clone, yet binds poorly with traditional opioid receptors.
orphanin FQ Binding (binds) of KOR-3 opioid receptor associated with orphanin and opioid receptor
6) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430891 Disease Relevance 0.32 Pain Relevance 0.56
In the present analysis, we compare the distribution of orphanin receptor mRNA expression with that of orphanin FQ binding at the ORL1 receptor in the adult rat central nervous system (CNS).
orphanin FQ Binding (binding) of ORL1 receptor in CNS associated with orphanin and central nervous system
7) Confidence 0.45 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464356 Disease Relevance 0 Pain Relevance 0.81
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1.
nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid
8) Confidence 0.44 Published 1997 Journal Peptides Section Abstract Doc Link 9213368 Disease Relevance 0.15 Pain Relevance 0.46
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1.
nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid
9) Confidence 0.43 Published 1997 Journal Life Sci. Section Abstract Doc Link 9096263 Disease Relevance 0.07 Pain Relevance 0.43
Nociceptin (orphanin FQ) is a novel, opioid-like, heptadecapeptide that is an endogenous ligand for the opioid receptor-like (ORL1) receptor.
Nociceptin Binding (ligand) of ORL1 associated with orphanin, opioid receptor and opioid
10) Confidence 0.41 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9348341 Disease Relevance 0.20 Pain Relevance 0.80
Nociceptin (orphanin FQ) is a novel, opioid-like, heptadecapeptide that is an endogenous ligand for the opioid receptor-like (ORL1) receptor.
orphanin FQ Binding (ligand) of ORL1 associated with orphanin, opioid receptor and opioid
11) Confidence 0.40 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9348341 Disease Relevance 0.20 Pain Relevance 0.80
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the G-protein coupled, opioid-like receptor ORL1.
nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid
12) Confidence 0.40 Published 1997 Journal Peptides Section Abstract Doc Link 9285926 Disease Relevance 0 Pain Relevance 0.36
Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli.
Nociceptin Binding (ligand) of opioid-receptor-like1 in neurons associated with orphanin, opioid and excitatory amino acid
13) Confidence 0.40 Published 1996 Journal J. Neurophysiol. Section Title Doc Link 8930296 Disease Relevance 0.22 Pain Relevance 0.74
Nociceptin, also referred to as orphanin FQ, is believed to be the endogenous ligand for the ORL1.
Nociceptin Binding (ligand) of ORL1 associated with orphanin
14) Confidence 0.40 Published 1997 Journal Neuroscience Section Abstract Doc Link 9330354 Disease Relevance 0.09 Pain Relevance 0.59
Nociceptin is an endogenous ligand for the opioid receptor-like 1 (ORL1) receptor.
Nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid receptor
15) Confidence 0.40 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15224144 Disease Relevance 0.71 Pain Relevance 0.64
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a recently discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1.
nociceptin Binding (ligand) of ORL1 associated with orphanin and opioid
16) Confidence 0.39 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9879748 Disease Relevance 0 Pain Relevance 0.65
The heptadecapeptide orphanin FQ (OFQ), also known as nociceptin (NOC), is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1.
orphanin FQ Binding (ligand) of ORL1 associated with orphanin and opioid
17) Confidence 0.39 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9920456 Disease Relevance 0 Pain Relevance 0.79
Nociceptin/orphanin FQ (NC) binds with high affinity to the opioid receptor-like1 (ORL1) receptor.
orphanin FQ Binding (binds) of ORL1 associated with orphanin and opioid receptor
18) Confidence 0.39 Published 2000 Journal Peptides Section Abstract Doc Link 10998542 Disease Relevance 0.09 Pain Relevance 0.51
Apparently, this truncated ORL1 does not function as a receptor for nociceptin or other ligands tested.
nociceptin Binding (receptor) of ORL1 associated with orphanin
19) Confidence 0.35 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10814826 Disease Relevance 0 Pain Relevance 0.42
Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat.
Nociceptin Binding (ligand) of ORL1 associated with orphanin
20) Confidence 0.35 Published 1998 Journal Regul. Pept. Section Title Doc Link 9879748 Disease Relevance 0 Pain Relevance 0.95

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