INT66536

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) DNA binding (Fos) response to stress (Fos)
cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Il1a (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antagonist 1 99.54 Very High Very High Very High
opiate 1 99.14 Very High Very High Very High
nalone 2 98.92 Very High Very High Very High
Morphine 8 97.82 Very High Very High Very High
Cytokine 1 59.44 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, using immunocytochemical staining of FOS, we demonstrate that chronic exposure to morphine attenuates the cellular responsiveness to IL-1 and to morphine in the PVN and SON, whereas pretreatment with naloxone, an opiate receptor antagonist, does not reverse the effect of IL-1 on FOS expression.
IL-1 Regulation (effect) of Gene_expression (expression) of FOS associated with nalone, antagonist, opiate and morphine
1) Confidence 0.59 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930328 Disease Relevance 0 Pain Relevance 0.91

General Comments

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