INT6656

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 135
Total Number 136
Disease Relevance 24.73
Pain Relevance 72.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
SH-SY5Y 9
NG108-15 7
embryonic kidney 5
ovary 4
oocytes 4
YY1 (Homo sapiens)
YY1 - Y318F (1)
Pain Link Frequency Relevance Heat
opioid receptor 280 100.00 Very High Very High Very High
agonist 186 100.00 Very High Very High Very High
Delta opioid receptors 143 100.00 Very High Very High Very High
Opioid 135 100.00 Very High Very High Very High
Gabapentin 49 100.00 Very High Very High Very High
opiate 33 100.00 Very High Very High Very High
gABA 29 100.00 Very High Very High Very High
mu opioid receptor 26 100.00 Very High Very High Very High
Kinase C 25 100.00 Very High Very High Very High
Kappa opioid receptor 23 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 32 99.86 Very High Very High Very High
Glioma 12 99.86 Very High Very High Very High
Breast Cancer 1 99.84 Very High Very High Very High
Smith-lemli-opitz Syndrome 6 99.82 Very High Very High Very High
Small Cell Lung Cancer 7 99.74 Very High Very High Very High
Cancer 21 99.68 Very High Very High Very High
Polycystic Ovary Syndrome 5 99.68 Very High Very High Very High
Post Operative Pain 2 99.64 Very High Very High Very High
Lung Cancer 13 99.40 Very High Very High Very High
Ganglion Cysts 18 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to elucidate the mechanisms of the neuronal anti-opioid activity of Neuropeptide FF, we have transfected the SH-SY5Y neuroblastoma cell line, which expresses mu- and delta-opioid receptors, with the human NPFF1 receptor.
Gene_expression (expresses) of delta in SH-SY5Y associated with neuroblastoma, neuropeptide, delta opioid receptors and opioid
1) Confidence 0.75 Published 2006 Journal Peptides Section Abstract Doc Link 16488058 Disease Relevance 0.10 Pain Relevance 0.56
Using cultured SH-SY5Y neuroblastoma cells, which naturally express mu- and delta-opioid receptors, we investigated whether mu-opioid receptor agonists can activate PKC by measuring enzyme translocation to the membrane fraction.
Gene_expression (express) of delta in SH-SY5Y associated with neuroblastoma, kinase c, agonist, opioid receptor and delta opioid receptors
2) Confidence 0.75 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930730 Disease Relevance 0.17 Pain Relevance 1.18
Co-expression of mu and delta opioid receptors as receptor-G protein fusions enhances both mu and delta signalling via distinct mechanisms.
Gene_expression (expression) of delta associated with nociceptor and delta opioid receptors
3) Confidence 0.75 Published 2008 Journal J. Neurochem. Section Title Doc Link 18182056 Disease Relevance 0.31 Pain Relevance 0.99
Post hoc morphological analysis revealed that those interneurons heavily innervating the pyramidal cell body layer were much more likely to express mu-opioid receptors, whereas cells with axons ramifying in the pyramidal neuron dendritic layers were more likely to express delta-opioid receptors, as defined by the generation of outward currents.
Gene_expression (express) of delta in interneurons associated with pyramidal cell, mu opioid receptor and delta opioid receptors
4) Confidence 0.75 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870941 Disease Relevance 0 Pain Relevance 0.75
These data show that lung cancers with neuroendocrine features express human brain delta opioid receptors in contrast to normal lung, and that the delta opioid receptor mRNA in lung cancer is not mutated.
Gene_expression (express) of delta in lung associated with lung cancer, opioid receptor and delta opioid receptors
5) Confidence 0.75 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9673405 Disease Relevance 0.93 Pain Relevance 0.25
The hypothesis that the rate of agonist-stimulated [(35)S]GTPgammaS binding is dependent upon agonist efficacy was tested using membranes from C6 glioma cells expressing mu- or delta-opioid receptors.
Gene_expression (expressing) of delta associated with agonist, delta opioid receptors and glioma
6) Confidence 0.75 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752111 Disease Relevance 0.10 Pain Relevance 1.09
Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element.
Gene_expression (expressed) of Delta in T cells associated with delta opioid receptors
7) Confidence 0.75 Published 1997 Journal J. Immunol. Section Title Doc Link 9548483 Disease Relevance 0.09 Pain Relevance 0.52
Combinations of two different types of opioid receptors - delta-, kappa-, mu-opioid receptors (DOR, KOR, and MOR) and opioid receptor-like receptor 1 (ORL(1)) - were co-expressed with the alpha subunit of G(16) in COS-7 cells, and the ability of various selective agonists to induce activation of phospholipase Cbeta was examined.
Gene_expression (co-expressed) of delta associated with agonist, mu opioid receptor and opioid receptor
8) Confidence 0.75 Published 2002 Journal Neurosignals Section Abstract Doc Link 12077485 Disease Relevance 0 Pain Relevance 0.39
Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
Gene_expression (Overexpression) of delta associated with kinase c, inflammation, syndrome and pheochromocytoma
9) Confidence 0.75 Published 2009 Journal Horm. Metab. Res. Section Title Doc Link 19048456 Disease Relevance 1.24 Pain Relevance 0.36
SH-SY5Y neural cells expressing mu- and delta-opioid receptors were maintained viable in isotonic, sodium-free buffer in vitro.
Gene_expression (expressing) of delta in SH-SY5Y associated with delta opioid receptors
10) Confidence 0.75 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9048750 Disease Relevance 0 Pain Relevance 0.12
Using a mouse model of postoperative pain, we assessed the expression of MOR and delta opioid receptors (DORs) and the efficacy of Herpes Simplex vector-mediated proenkephalin release (SHPE) preventing postoperative nociceptive sensitization induced by remifentanil or surgical incision.
Gene_expression (expression) of delta associated with nociception, herpes simplex virus, ultiva, delta opioid receptors, opioid receptor and perioperative pain
11) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 0.68 Pain Relevance 1.12
To determine whether delta-receptors respond similarly, or whether this adaptation is unique for mu-receptors, this study examined the effects of prolonged agonist exposure on the intrinsic activity of several delta-opioid ligands in GH(3) cells expressing delta-receptors.
Gene_expression (expressing) of delta associated with agonist and opioid
12) Confidence 0.75 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183665 Disease Relevance 0 Pain Relevance 1.01
When the truncated mu(C delta 45) receptor was stably expressed in human embryonic kidney (HEK) 293 cells, the efficacy and the potency of [D-Ala2,N-Me-Phe4,Gly-ol5]enkephalin (DAMGO), a specific mu-opioid receptor agonist, to inhibit forskolin-stimulated adenylate cyclase activity were not significantly affected.
Gene_expression (expressed) of delta in HEK associated with agonist, opioid receptor, enkephalin and potency
13) Confidence 0.75 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037504 Disease Relevance 0 Pain Relevance 0.36
Similarly, when mu- and delta-opioid (DOR1TAG) receptors were expressed in the same system, overexpression of beta-adrenergic receptor kinase 2 elevated agonist-induced phosphorylation for both receptors.
Gene_expression (expressed) of delta associated with agonist and opioid
14) Confidence 0.75 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.06 Pain Relevance 0.63
We find that co-expression of mu and delta receptors in heterologous cells followed by selective immunoprecipitation results in the isolation of mu-delta heterodimers.
Gene_expression (co-expression) of delta
15) Confidence 0.75 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069979 Disease Relevance 0.08 Pain Relevance 0.80
Expression of functional delta opioid receptors in vascular smooth muscle.
Gene_expression (Expression) of delta in smooth muscle associated with delta opioid receptors
16) Confidence 0.75 Published 2000 Journal Int. J. Mol. Med. Section Title Doc Link 11078827 Disease Relevance 0 Pain Relevance 0.40
In this study, we investigated the interactions of p-fluorofentanyl, an opioid designer drug, fentanyl, sufentanyl, and morphine on cloned human mu-, kappa-, and delta-opioid receptors coexpressed with heteromultimeric G protein-coupled inwardly rectifying K(+) channels (GIRK1/GIRK2) and a regulator of G protein signaling (RGS4) in Xenopus oocytes.
Gene_expression (coexpressed) of delta in oocytes associated with delta opioid receptors, opioid and morphine
17) Confidence 0.75 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10945855 Disease Relevance 0 Pain Relevance 0.49
Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR alpha/beta and TCR gamma/delta.
Neg (negative) Gene_expression (negative) of delta associated with cancer
18) Confidence 0.75 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 11107059 Disease Relevance 0.68 Pain Relevance 0.08
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Gene_expression (expressed) of delta in embryonic kidney associated with gaba and isoflurane
19) Confidence 0.75 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.39 Pain Relevance 0.95
The synergy (i.e. a more than additive effect) was observed with combinations of these two opioid agonists on differentiated SH-SY5Y cells functionally expressing both mu- and delta-opioid receptors.
Gene_expression (expressing) of delta in SH-SY5Y associated with mu agonist and delta opioid receptors
20) Confidence 0.75 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11165441 Disease Relevance 0 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox