INT66598

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Context Info
Confidence 0.04
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.83
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GPER) endoplasmic reticulum (GPER) plasma membrane (GPER)
signal transducer activity (GPER)
Anatomy Link Frequency
muscles 1
platelet 1
cochlear 1
eosinophil 1
heart 1
GPER (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
depression 3 99.92 Very High Very High Very High
dexamethasone 28 99.80 Very High Very High Very High
anesthesia 10 82.60 Quite High
ketamine 1 82.16 Quite High
Inflammation 77 75.64 Quite High
Angina 3 75.00 Quite High
Inflammatory response 14 50.00 Quite Low
Catecholamine 6 18.56 Low Low
halothane 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 8 100.00 Very High Very High Very High
Anorexia 7 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Xerostomia 4 100.00 Very High Very High Very High
Constipation 4 100.00 Very High Very High Very High
Fatigue 8 99.96 Very High Very High Very High
Depression 3 99.92 Very High Very High Very High
Coronary Artery Disease 2 99.80 Very High Very High Very High
Urological Neuroanatomy 14 99.56 Very High Very High Very High
Anxiety 4 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The symptoms included in this list were: Lack of energy, tiredness, lack of appetite, pain, constipation, nausea, dry mouth, depression, anxiety, difficulty sleeping, tenseness, vomiting, shortness of breath, lack of sexual interest, irritability, nervousness, heartburn, dizziness, sore muscles, and numbness or tingling of the hands or feet.


Negative_regulation (lack) of dry mouth in muscles associated with pain, constipation, depression, vomiting, gastroesophageal reflux disease, xerostomia, anorexia, hypesthesia, dizziness, fatigue, anxiety and dyspnea
1) Confidence 0.04 Published 2003 Journal BMC Cancer Section Body Doc Link PMC317311 Disease Relevance 1.66 Pain Relevance 0.15
The histograms, in Figure 4A, show the increase in fluorescence intensity over the control responses upon the addition of PAF, as well as the inhibitory effect of feG on PAF enhancement of CD11b antibody binding.
Negative_regulation (effect) of feG
2) Confidence 0.04 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.19 Pain Relevance 0
In another study we found that feG (10-9M) inhibited by 61.8 ± 17.7% (n = 3) eosinophil binding to gelatin, while having no effect on the binding of these cells to fibronectin (5.7 ± 7.1% inhibition; n = 5).


Negative_regulation (inhibited) of feG in eosinophil
3) Confidence 0.04 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.48 Pain Relevance 0
The inhibitory effect of feG, seen on the binding of CD11b under basal conditions for both circulating and peritoneal cells, was not observed in rats that received an antigen challenge 24 h previously.
Negative_regulation (effect) of feG
4) Confidence 0.04 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.18 Pain Relevance 0.06
The inhibitory effect of feG, seen on basal expression of CD11b was not observed in rats that had received an antigen challenge 24 h previously (Figure 3).
Negative_regulation (effect) of feG
5) Confidence 0.03 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.45 Pain Relevance 0.11
Interestingly, at 3 h after antigen challenge the MPO content of the heart decreased, relative to control animals, in both feG and dexamethasone treated rats.
Negative_regulation (decreased) of feG in heart associated with urological neuroanatomy and dexamethasone
6) Confidence 0.03 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.49 Pain Relevance 0.20
Results demonstrated that EGb 761 partly counteracted sodium salicylate-induced decreases in cochlear blood flow (CBF) and enhanced CBF increases induced by hypoxia.
Negative_regulation (decreases) of cochlear blood flow in cochlear associated with hypoxia
7) Confidence 0.00 Published 1996 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 8932425 Disease Relevance 0.10 Pain Relevance 0.12
OBJECTIVES: In our study we sought to determine whether mean platelet volume (MPV), measured on admission, could be used in determining decreased coronary blood flow (CBF) in stable coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI).
Negative_regulation (decreased) of coronary blood flow in platelet associated with coronary artery disease
8) Confidence 0.00 Published 2008 Journal J Invasive Cardiol Section Abstract Doc Link 18316827 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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