INT666

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 124
Total Number 132
Disease Relevance 54.61
Pain Relevance 33.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
neurons 7
striatum 3
Neural 2
spinal cord 2
ACC neurons 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 553 100.00 Very High Very High Very High
Pain 120 100.00 Very High Very High Very High
Kinase C 104 100.00 Very High Very High Very High
metalloproteinase 86 100.00 Very High Very High Very High
qutenza 28 100.00 Very High Very High Very High
COX2 27 100.00 Very High Very High Very High
Enkephalin 27 100.00 Very High Very High Very High
ischemia 58 99.88 Very High Very High Very High
Dorsal horn 14 99.88 Very High Very High Very High
Anterior cingulate cortex 160 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 941 100.00 Very High Very High Very High
Apoptosis 561 100.00 Very High Very High Very High
Cytomegalovirus Infection 186 100.00 Very High Very High Very High
Death 157 100.00 Very High Very High Very High
Shock 40 100.00 Very High Very High Very High
Cv Unclassified Under Development 35 99.88 Very High Very High Very High
Targeted Disruption 523 99.78 Very High Very High Very High
Colon Cancer 20 99.76 Very High Very High Very High
Aids-related Complex 13 99.76 Very High Very High Very High
Convulsion 30 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AP-1 is usually expressed at low basal cellular levels, but can be up-regulated by a variety of exogenous stimuli which results in synthesis of Fos and Jun proteins and increased AP-1 DNA binding activity.
Gene_expression (expressed) of AP-1
1) Confidence 0.78 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.31 Pain Relevance 0.29
When endotoxin was administered to mice in order to elicit a hepatic inflammatory response without necrosis, increases in c-jun expression occurred without accompanying changes in AP-1 activity, indicating a different mechanism of action.
Gene_expression (expression) of c-jun associated with necrosis and inflammatory response
2) Confidence 0.78 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.59 Pain Relevance 0.57
B was sufficient to downregulate expression of AP-1 (c-jun) and MMPs, which suggests signaling was from the NF-?
Gene_expression (expression) of AP-1 associated with metalloproteinase
3) Confidence 0.77 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.15 Pain Relevance 0.17
B was sufficient to downregulate expression of AP-1 (c-jun) and MMPs, which suggests signaling was from the NF-?
Gene_expression (expression) of c-jun associated with metalloproteinase
4) Confidence 0.77 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.15 Pain Relevance 0.17
As mentioned above, the reports in the literature on AP-1 activation suggest that numerous upstream targets, especially protein kinases, might be involved in signaling pathways that control the expression of AP-1.
Gene_expression (expression) of AP-1
5) Confidence 0.77 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.09 Pain Relevance 0.04
This association may have induced the expression of several cytokines and immediate early genes in dorsal root ganglion and spinal cord neurons via the TNF signaling pathway.
Gene_expression (expression) of immediate early in spinal cord neurons
6) Confidence 0.75 Published 2004 Journal Spine Section Body Doc Link 15131433 Disease Relevance 0.05 Pain Relevance 0
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Gene_expression (expression) of AP-1 associated with death
7) Confidence 0.75 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.24
V-PYRRO/NO also suppressed the expression of acute phase protein genes and genes related to cell-death pathways, such as c-jun/AP-1, nuclear factor-kappaB, early response growth factor-1, heme oxygenase-1, caspase-3, growth arrest, and DNA-damaging protein-153.
Gene_expression (expression) of c-jun associated with death
8) Confidence 0.75 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.24
Analysis of gene expression regulation using pharmacologic tools or A2A receptor-deficient mice (A2A-/-) shows that the A2A receptor positively and tonically controls the expression of enkephalin and immediate early genes in striatopallidal neurons.
Gene_expression (expression) of immediate early in neurons associated with enkephalin
9) Confidence 0.75 Published 2003 Journal Neurology Section Abstract Doc Link 14663005 Disease Relevance 0.36 Pain Relevance 0.33
In rats chronically infused into the 4th ventricle for 28 days with LPS (via osmotic minipump), there was a region-selective microglia activation, impaired hippocampal-depen-dent memory and altered behaviorally-induced expression of the immediate early gene Arc [234].
Gene_expression (expression) of immediate early in microglia associated with aids-related complex
10) Confidence 0.75 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.77 Pain Relevance 0.13
Expression of immediate early genes, such as c-fos, has been extensively used as a marker of neural activity.
Gene_expression (Expression) of immediate early in neural
11) Confidence 0.75 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19931567 Disease Relevance 0 Pain Relevance 0.09
The expression of the immediate early gene c-Fos was analyzed to map the distribution of neurons whose activity is regulated by central administration of the NPFF(2)-selective agonist dNPA in naive mice and in animals who had received a systemic injection of morphine.
Spec (analyzed) Gene_expression (expression) of immediate early in neurons associated with agonist and morphine
12) Confidence 0.75 Published 2010 Journal Synapse Section Abstract Doc Link 20336629 Disease Relevance 0.06 Pain Relevance 0.54
Thus, the P-Erk expression pattern in the region is different from that of immediate early genes, such as c-Fos, which is widely expressed in ACC neurons located in all layers after formalin injection as previously reported [18].
Gene_expression (expressed) of immediate early in ACC neurons associated with anterior cingulate cortex
13) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.69 Pain Relevance 0.64
Further studies found that the level of expression of several immediate early genes in VTA, as well as other motivation related areas, can be modulated by the specific social context in which males sing [20], [33].
Gene_expression (expression) of immediate early associated with ventral tegmentum
14) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533700 Disease Relevance 0.10 Pain Relevance 0.37
Expression of Egr1, as well as other immediate early genes, is up-regulated in response to a number of noxious stimuli.
Gene_expression (Expression) of immediate early
15) Confidence 0.75 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 0.54 Pain Relevance 0.28
Spinal anesthesia by local anesthetics stimulates the enzyme protein kinase C and induces the expression of an immediate early oncogene, c-Fos.
Gene_expression (expression) of immediate early in Spinal associated with kinase c, anesthesia and local anesthetic
16) Confidence 0.75 Published 1996 Journal Anesth. Analg. Section Title Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.92
To understand the biochemical mechanisms involved in spinal anesthesia, we measured protein kinase C (PKC) activity and expression of immediate early oncogene protein, c-Fos, in the spinal cord.
Gene_expression (expression) of immediate early in spinal cord associated with kinase c, anesthesia and spinal cord
17) Confidence 0.75 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.71
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Gene_expression (expression) of Jun
18) Confidence 0.72 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.06 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Gene_expression (expression) of Jun in hippocampus associated with hippocampus
19) Confidence 0.72 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
and other cytokines induce expression of c-fos and the c-jun oncogene [22-25], we deduced that abnormal expression of c-Fos can be observed in VMC.
Gene_expression (expression) of c-jun associated with coronary heart disease and cytokine
20) Confidence 0.71 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.63 Pain Relevance 0.55

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