INT66606

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 27.79
Pain Relevance 11.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR1) signal transducer activity (CXCR1)
Anatomy Link Frequency
endothelial cells 4
T-cell 3
fibroblasts 2
endometrium 2
monocyte 2
CXCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 626 100.00 Very High Very High Very High
chemokine 491 100.00 Very High Very High Very High
antagonist 39 99.96 Very High Very High Very High
Dismenorea 8 99.88 Very High Very High Very High
dexamethasone 3 99.80 Very High Very High Very High
Nerve growth factor 11 99.36 Very High Very High Very High
Opioid 6 99.14 Very High Very High Very High
cytokine 157 98.90 Very High Very High Very High
MU agonist 10 98.68 Very High Very High Very High
substance P 10 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 629 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 152 100.00 Very High Very High Very High
Infection 83 100.00 Very High Very High Very High
Dysmenorrhea 8 99.88 Very High Very High Very High
Pulmonary Disease 398 99.80 Very High Very High Very High
Leukemia 4 99.20 Very High Very High Very High
Breast Cancer 644 99.12 Very High Very High Very High
INFLAMMATION 404 98.60 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 98.32 Very High Very High Very High
Gastritis 10 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kappa-opioid regulation of thymocyte IL-7 receptor and C-C chemokine receptor 2 expression.
Gene_expression (expression) of C-C in thymocyte associated with chemokine, opioid and cytokine
1) Confidence 0.75 Published 2000 Journal J. Immunol. Section Title Doc Link 10799865 Disease Relevance 0 Pain Relevance 0.63
Adenomyosis foci expressed higher epithelial CXCR1 compared with the homologous eutopic endometrium and normal endometrium.
Gene_expression (expressed) of CXCR1 in endometrium
2) Confidence 0.73 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVE: To investigate the expression of interleukin-8 (IL-8) receptors CXCR1 and CXCR2 in adenomyosis.
Spec (investigate) Gene_expression (expression) of CXCR1 associated with dismenorea
3) Confidence 0.73 Published 2006 Journal Fertil. Steril. Section Abstract Doc Link 16500343 Disease Relevance 0.17 Pain Relevance 0.17
Studies by ourselves and other workers have shown that monocytes/macrophages express several other CXC chemokine receptors in RA, including CXCR1, CXCR2 and CXCR4 [15,16,46].
Gene_expression (express) of CXCR1 in macrophages associated with chemokine and rheumatoid arthritis
4) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.01 Pain Relevance 0.71
MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of CXCR1 and CXCR2 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with normal endometrium.
Gene_expression (presence) of CXCR1 in endometrium
5) Confidence 0.64 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.08 Pain Relevance 0
INTERVENTION(S): Tissue sections were immunostained with murine monoclonal anti-human CXCR1 and CXCR2 antibodies.
Gene_expression (immunostained) of CXCR1
6) Confidence 0.64 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.09 Pain Relevance 0
The IL-8 receptors CXCR1 and CXCR2 have been reported to be present in a variety of cell types including inflammatory cells, endothelial cells, and fibroblasts [46].
Gene_expression (present) of CXCR1 in fibroblasts associated with inflammation
7) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.45 Pain Relevance 0.21
Subsequent studies have confirmed the expression of CXCR2, not CXCR1, to be the primary functional chemokine receptor in mediating endothelial cell chemotaxis [18,19].
Gene_expression (expression) of CXCR1 in endothelial cell associated with chemokine
8) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.61 Pain Relevance 0.37
Concerning IL-8 receptors, it has been observed that CXCR1 expression was extremely low in breast cancer cells, whereas most of the cells investigated showed a higher expression of CXCR2 [52].
Gene_expression (expression) of CXCR1 associated with breast cancer
9) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.19 Pain Relevance 0.13
Interestingly, CXCR2, but not CXCR1, is expressed by a variety of neurones and astrocytes [14] and may be involved in the directed migration of specific subsets of neurones.
Gene_expression (expressed) of CXCR1 in astrocytes
10) Confidence 0.56 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.41
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
Gene_expression (/) of CXCR1 associated with chemokine
11) Confidence 0.54 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.68 Pain Relevance 0.33
Recent studies indicated that CXCR1 and CXCR2 are highly expressed on human microvascular endothelial cells (HMEC) [53].
Gene_expression (expressed) of CXCR1 in endothelial cells
12) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.81 Pain Relevance 0.08
Endothelial cells were found to express CXCR2 in vitro and in vivo, but not CXCR1.
Gene_expression (express) of CXCR1 in Endothelial cells
13) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.38 Pain Relevance 0.11
IL-8 mediates its effects through the activation of two high-affinity G-protein coupled receptors, CXCR1 and CXCR2 [29], both of which are expressed by LNCaP cells [30], [31].
Gene_expression (expressed) of CXCR1
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.69 Pain Relevance 0.04
Bendre and coworkers [47] demonstrated that IL-8 binds to CXCR1 present on osteoclast precursors and enhances osteoclast differentiation independent of RANKL.
Gene_expression (present) of CXCR1 in osteoclast
15) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.40 Pain Relevance 0.08
We also confirmed the eccentric-induced expression of six transcripts by quantitative RT-PCR (cardiac ankyrin-repeated protein, chemokine ligand 2, CCAAT/enhancer binding protein delta, IL-1 receptor, tenascin C, and cysteine-rich angiogenic inducer 61).
Gene_expression (expression) of IL-1 receptor associated with chemokine
16) Confidence 0.28 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12937035 Disease Relevance 0.09 Pain Relevance 0.17
The chemokine receptor genes were differentially expressed, with upregulation of CXCR4, CCRL2 and CCR5 and downregulation of CXCR1 and CXCR2.
Gene_expression (expressed) of CXCR1 associated with chemokine
17) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.63 Pain Relevance 0.36
Furthermore, CXCL8 is a chemoattractant that will attract many different cell types expressing CXCR1 or CXCR2 including DCs [45] and the presence of CXCL8 in blood may affect their ability to exit the blood stream and affect their viability.
Gene_expression (expressing) of CXCR1 in blood
18) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.47 Pain Relevance 0.21
These were CCR1, CCR2a, CCR5, CCR7, CCR9, CX3CR1, CXCR1, CXCR2, CXCR4, CXCR5, CXCR6 (STRL33) and Bob (Table 3).
Gene_expression (These) of CXCR1
19) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.02 Pain Relevance 0.80
The chemokine receptors implicated in COPD, include CXCR1 and CXCR2 which are expressed on monocytes and neutrophils; CXCR3, which is expressed on T-cell and B-cells; and receptors of the CCR series (?
Gene_expression (expressed) of CXCR1 in B-cells associated with chemokine and pulmonary disease
20) Confidence 0.24 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.25 Pain Relevance 0.53

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