INT66607

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 2.81
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
keratinocyte 2
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
cytokine 3 99.80 Very High Very High Very High
c fibre 1 94.12 High High
agonist 1 79.60 Quite High
antagonist 5 57.92 Quite High
cva 4 50.00 Quite Low
cINOD 3 25.00 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 37 100.00 Very High Very High Very High
Adhesions 18 100.00 Very High Very High Very High
Skin Cancer 14 95.80 Very High Very High Very High
Necrosis 3 93.72 High High
Cancer 4 93.36 High High
Acute Coronary Syndrome 5 88.96 High High
Coronary Artery Disease 4 83.68 Quite High
Calcification 12 83.44 Quite High
Disorder Of Lipid Metabolism 5 74.92 Quite High
Obesity 2 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Spec (investigate) Regulation (effect) of Positive_regulation (upregulation) of intercellular adhesion molecule-1 associated with inflammation and adhesions
1) Confidence 0.42 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.71 Pain Relevance 0.05
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Spec (investigate) Regulation (effect) of Positive_regulation (upregulation) of ICAM-1 associated with inflammation and adhesions
2) Confidence 0.42 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.71 Pain Relevance 0.05
As normal human keratinocytes have been reported to express SP receptors, we studied the effects of SP on keratinocyte activation markers such as ICAM-1 induction and cytokine production.
Regulation (effects) of Positive_regulation (induction) of ICAM-1 in keratinocyte associated with cytokine and substance p
3) Confidence 0.25 Published 1996 Journal Arch. Dermatol. Res. Section Abstract Doc Link 8932586 Disease Relevance 0 Pain Relevance 0.56
In contrast, sICAM-1 and sVCAM-1 levels remained unchanged or increased above baseline in Group IB at 72 h (Figure 3).
Neg (unchanged) Regulation (unchanged) of Neg (unchanged) Positive_regulation (increased) of sICAM-1
4) Confidence 0.10 Published 2004 Journal Thromb J Section Body Doc Link PMC406420 Disease Relevance 0.88 Pain Relevance 0
This SNP was also associated with ICAM-1 (P = .037) and E-selectin (P = .0001); however, the genotypic means did not fit a classical single gene model, as the levels of both ICAM-1 and E-selectin for the heterozygote (T/C) class were greater than the means for the homozygote classes.
Regulation (greater) of Positive_regulation (levels) of ICAM-1
5) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.52 Pain Relevance 0.04

General Comments

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